公开(公告)号：US07563437B2

公开(公告)日：2009-07-21

申请号：US11353293

申请日：2006-02-13

申请人： Roland Carlsson ,  Elisabeth Sonesson ,  Yvonne Stenberg ,  Leif Strandberg ,  Gideon Goldstein

发明人： Roland Carlsson ,  Elisabeth Sonesson ,  Yvonne Stenberg ,  Leif Strandberg ,  Gideon Goldstein

IPC分类号： A61K39/395

CPC分类号： C07K16/1072 ,  C07K2317/92

摘要： A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.

摘要翻译： 单个分离的抗体或其抗体片段结合HIV-1多重菌株和亚型中显示的HIV-1 Tat蛋白的表位内的多个变体序列。 这种“泛表位”抗体可用于HIV-1感染的治疗和预防组合物和治疗，不管应变如何。 该泛表位抗体可用于基于生物样品中Tat蛋白量的测量来检测HIV-1水平的测定中。

公开(公告)号：US20060211108A1

公开(公告)日：2006-09-21

申请号：US11353293

申请日：2006-02-13

申请人： Roland Carlsson ,  Elisabeth Sonesson ,  Yvonne Stenberg ,  Leif Strandberg ,  Gideon Goldstein

发明人： Roland Carlsson ,  Elisabeth Sonesson ,  Yvonne Stenberg ,  Leif Strandberg ,  Gideon Goldstein

IPC分类号： C12Q1/68 ,  C12N5/06 ,  C12N5/16

CPC分类号： C07K16/1072 ,  C07K2317/92

摘要： A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.