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公开(公告)号:US20100273724A1
公开(公告)日:2010-10-28
申请号:US12831804
申请日:2010-07-07
申请人: Elizabeth L. S. Cheu , Lewis Siu Leung Choi , Doug Ta Hung Chou , Allen W. Davidoff , Alan M. Ezrin , Grace Jung , Bertrand M.C. Plouvier , Aregahegn S. Yifru
发明人: Elizabeth L. S. Cheu , Lewis Siu Leung Choi , Doug Ta Hung Chou , Allen W. Davidoff , Alan M. Ezrin , Grace Jung , Bertrand M.C. Plouvier , Aregahegn S. Yifru
IPC分类号: A61K31/4015 , C07D403/12 , C07D401/12 , C07D417/14 , C07D513/04 , A61K31/496 , A61K31/4439 , A61K31/4155 , A61K38/08 , A61K31/55 , A61K31/501 , A61P9/06 , C12N5/00
CPC分类号: C07H15/203 , A61K47/54 , A61K47/555 , A61K47/60 , A61K51/04 , C07B2200/05 , C07C257/06 , C07D207/12 , C07D209/88 , C07D209/94 , C07F9/572
摘要: This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed
摘要翻译: 本发明涉及某些离子通道调节化合物的PEG衍生物,药物偶联物和同位素衍生物。 还公开了药物组合物和使用方法
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公开(公告)号:US07786119B2
公开(公告)日:2010-08-31
申请号:US11547419
申请日:2005-03-31
申请人: Elizabeth L. S. Cheu , Lewis Siu Leung Choi , Doug Ta Hung Chou , Allen W. Davidoff , Alan M. Ezrin , Grace Jung , Bertrand M. C. Plouvier , Aregahegn S. Yifru
发明人: Elizabeth L. S. Cheu , Lewis Siu Leung Choi , Doug Ta Hung Chou , Allen W. Davidoff , Alan M. Ezrin , Grace Jung , Bertrand M. C. Plouvier , Aregahegn S. Yifru
IPC分类号: A61K31/501
CPC分类号: C07H15/203 , A61K47/54 , A61K47/555 , A61K47/60 , A61K51/04 , C07B2200/05 , C07C257/06 , C07D207/12 , C07D209/88 , C07D209/94 , C07F9/572
摘要: This invention is directed to drug conjugates of certain ion channel modulating compounds having the following formula: wherein A, X, R1, R2, R3, R4, R5, LB, L and DM are defined herein, including isolated enantiomeric and diastereomeric isomers thereof, and mixtures thereof. Pharmaceutical compositions and methods of use are also disclosed.
摘要翻译: 本发明涉及具有下式的某些离子通道调节化合物的药物偶联物:其中A,X,R1,R2,R3,R4,R5,LB,L和DM在本文中定义,包括其分离的对映异构体和非对映体异构体, 及其混合物。 还公开了药物组合物和使用方法。
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