公开(公告)号：US20070161108A1

公开(公告)日：2007-07-12

申请号：US11582136

申请日：2006-10-16

申请人： Ellen Harrer ,  Thomas Harrer

发明人： Ellen Harrer ,  Thomas Harrer

IPC分类号： C12Q1/00 ,  C12P1/00 ,  C12N5/08

CPC分类号： C07K14/47 ,  A61K39/00

摘要： The present invention refers to the use of Bob-1 protein, fragments or epitopes thereof and/or related sequences in a method to identify, to induce and/or to isolate Bob-1 specific or Bob-1 cross-reactive T-cells, preferably cytotoxic T-lymphocytes (CTL) and CD4+ T-helper cells. The T-cells according to the invention can be used to identify and diagnose various diseases, which are influenced by Bob-1 protein expression. The invention provides further the use of Bob-1 specific and/or Bob-1 cross-reactive T-cells, as well as peptides and/or nucleic acid sequences for inducing Bob-1 specific and/or Bob-1 cross-reactive T-cells, as medicament or vaccine and for the treatment of Bob-1 expressing tumors, lymphomas and autoimmune diseases.

摘要翻译： 本发明涉及在鉴定，诱导和/或分离Bob-1特异性或Bob-1交叉反应性T细胞的方法中使用Bob-1蛋白，其片段或表位和/或相关序列， 优选细胞毒性T淋巴细胞（CTL）和CD4 + T辅助细胞。 根据本发明的T细胞可用于鉴定和诊断受Bob-1蛋白表达影响的各种疾病。 本发明进一步提供了Bob-1特异性和/或Bob-1交叉反应性T细胞以及肽和/或核酸序列用于诱导Bob-1特异性和/或Bob-1交叉反应性T 细胞，作为药物或疫苗，用于治疗表达Bob-1的肿瘤，淋巴瘤和自身免疫性疾病。