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公开(公告)号:US07119207B2
公开(公告)日:2006-10-10
申请号:US09811218
申请日:2001-03-16
申请人: Brian Thomas O'Neill , Arthur Adam Nagel , John Michael Humphrey , Susan Beth Sobolov-Jaynes , Thomas Allen Chappie , Lawrence Albert Vincent , Eric Platt Arnold , Jianhua Huang
发明人: Brian Thomas O'Neill , Arthur Adam Nagel , John Michael Humphrey , Susan Beth Sobolov-Jaynes , Thomas Allen Chappie , Lawrence Albert Vincent , Eric Platt Arnold , Jianhua Huang
IPC分类号: C07D401/06 , C07D401/08 , A61K31/4523 , A61P25/06
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to certain benzoamide piperidine containing compounds and related compounds that exhibit activity as NK-1 receptor antagonists, (e.g., substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of central nervous system disorders, inflammatory disorders, cardiovascular disorders, ophthalmic disorders, gastrointestinal disorders, disorders caused by helicobacter pylori, disorders of the immune system, urinary incontinence, pain, migraine, emesis, angiogenesis and other disorders.