公开(公告)号：US07119207B2

公开(公告)日：2006-10-10

申请号：US09811218

申请日：2001-03-16

申请人： Brian Thomas O'Neill ,  Arthur Adam Nagel ,  John Michael Humphrey ,  Susan Beth Sobolov-Jaynes ,  Thomas Allen Chappie ,  Lawrence Albert Vincent ,  Eric Platt Arnold ,  Jianhua Huang

发明人： Brian Thomas O'Neill ,  Arthur Adam Nagel ,  John Michael Humphrey ,  Susan Beth Sobolov-Jaynes ,  Thomas Allen Chappie ,  Lawrence Albert Vincent ,  Eric Platt Arnold ,  Jianhua Huang

IPC分类号： C07D401/06 ,  C07D401/08 ,  A61K31/4523 ,  A61P25/06

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/10 ,  C07D491/10

摘要： The present invention relates to certain benzoamide piperidine containing compounds and related compounds that exhibit activity as NK-1 receptor antagonists, (e.g., substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of central nervous system disorders, inflammatory disorders, cardiovascular disorders, ophthalmic disorders, gastrointestinal disorders, disorders caused by helicobacter pylori, disorders of the immune system, urinary incontinence, pain, migraine, emesis, angiogenesis and other disorders.

公开(公告)号：US07365121B2

公开(公告)日：2008-04-29

申请号：US10779804

申请日：2004-02-18

申请人： Jianhua Huang ,  Donald G. Baird ,  James E. McGrath

发明人： Jianhua Huang ,  Donald G. Baird ,  James E. McGrath

IPC分类号： C08K3/04 ,  C08K3/40 ,  H01M8/00

CPC分类号： C08K7/02

摘要： A low cost method of fabricating bipolar plates for use in fuel cells utilizes a wet lay process for combining graphite particles, thermoplastic fibers, and reinforcing fibers to produce a plurality of formable sheets. The formable sheets are then molded into a bipolar plates with features impressed therein via the molding process. The bipolar plates formed by the process have conductivity in excess of 150 S/cm and have sufficient mechanical strength to be used in fuel cells. The bipolar plates can be formed as a skin/core laminate where a second polymer material is used on the skin surface which provides for enhanced conductivity, chemical resistance, and resistance to gas permeation.

摘要翻译： 制造用于燃料电池的双极板的低成本方法利用湿式铺设方法来组合石墨颗粒，热塑性纤维和增强纤维，以生产多个可成形片材。 然后将可成形片材模制成具有通过模制工艺在其中印刷的特征的双极板。 通过该方法形成的双极板具有超过150S / cm的电导率并且具有足够的机械强度以用于燃料电池。 双极板可以形成为皮肤/芯层压板，其中在皮肤表面上使用第二聚合物材料，其提供增强的导电性，耐化学性和耐气体渗透性。

公开(公告)号：US20060084750A1

公开(公告)日：2006-04-20

申请号：US11244401

申请日：2005-10-06

申请人： Jianhua Huang ,  Donald Baird ,  James McGrath

发明人： Jianhua Huang ,  Donald Baird ,  James McGrath

IPC分类号： C08K3/04

CPC分类号： H01M8/0226 ,  C08K3/013 ,  C08K3/04 ,  C08K7/02 ,  C08K7/04

摘要： A low cost method of fabricating bipolar plates for use in fuel cells utilizes a wet lay process for combining graphite particles, thermoplastic fibers, and reinforcing fibers to produce a plurality of formable sheets. The formable sheets are sandwiched between outer layers consisting of polymer and graphite particles, then molded into a bipolar plates with features impressed therein via the molding process. The bipolar plates formed by the process have sufficient mechanical strength and bulk conductivity to be used in fuel cells The outer layers provide for enhanced conductivity and resistance to gas permeation.

摘要翻译： 制造用于燃料电池的双极板的低成本方法利用湿式铺设方法来组合石墨颗粒，热塑性纤维和增强纤维，以生产多个可成形片材。 可成形片材夹在由聚合物和石墨颗粒组成的外层之间，然后通过模塑工艺模制成具有印痕特征的双极板。 通过该方法形成的双极板具有足够的机械强度和体积电导率用于燃料电池。外层提供增强的导电性和耐气体渗透性。

公开(公告)号：US20080305181A1

公开(公告)日：2008-12-11

申请号：US11578490

申请日：2005-04-18

申请人： Christopher D. Kontos ,  Jianhua Huang

发明人： Christopher D. Kontos ,  Jianhua Huang

IPC分类号： A61K35/34 ,  A61F2/06 ,  A61K31/7088

CPC分类号： A61K48/005 ,  A61K48/0075 ,  C12N9/16 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2710/10071

摘要： The present invention contemplates compositions and methods for the treatment of vascular grafts both ex vivo and in vivo. Ex vivo treatment comprises completely removing a vessel (i.e., vein or artery) from the body and treating with the compositions of the present invention. In vivo treatment comprises treating the vessel in vivo without removing the vessel completely from the body (albeit one or both ends of the vessel may be closed off in order to focus the treatment in the desired area and/or avoid systemic treatment). In one embodiment, at least a portion of the smooth muscle cells of a vessel (e.g., vein or artery) are transfected ex vivo or in vivo with a vector capable of expressing at least one phosphatase. In a preferred embodiment, smooth muscle cells are transfected with adenovirus vector comprising the gene encoding PTEN.

摘要翻译： 本发明考虑了用于离体和体内治疗血管移植物的组合物和方法。 离体治疗包括从体内完全除去血管（即静脉或动脉）并用本发明的组合物进行治疗。 体内治疗包括在体内处理血管而不从体内完全移除血管（尽管血管的一端或两端可被封闭以便将治疗集中在所需区域和/或避免全身治疗）。 在一个实施方案中，血管（例如静脉或动脉）的平滑肌细胞的至少一部分用能够表达至少一种磷酸酶的载体体外或体内转染。 在优选的实施方案中，用包含编码PTEN的基因的腺病毒载体转染平滑肌细胞。

公开(公告)号：USD718824S1

公开(公告)日：2014-12-02

申请号：US29483874

申请日：2014-03-04

申请人： Jianhua Huang

设计人： Jianhua Huang

公开(公告)号：US06887875B2

公开(公告)日：2005-05-03

申请号：US10154482

申请日：2002-05-22

申请人： Jianhua Huang ,  Kevin Hodggetts ,  Dario Doller ,  Ping Ge ,  Yasuchika Yamaguchi

发明人： Jianhua Huang ,  Kevin Hodggetts ,  Dario Doller ,  Ping Ge ,  Yasuchika Yamaguchi

IPC分类号： G01N33/566 ,  A61K31/00 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/505 ,  A61K31/5377 ,  A61K51/04 ,  A61P1/04 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D213/74 ,  C07D239/34 ,  C07D241/12 ,  C07D401/04 ,  C07D403/04 ,  C07D405/10 ,  G01N33/58 ,  C07D239/26 ,  A61K31/506

CPC分类号： A61K31/00 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D213/74 ,  C07D241/12 ,  C07D401/04

摘要： Diarylpyrimidine compounds of Formula I are provided, wherein. or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are independently chosen from: phenyl which is mono-, di-, or tri-substituted, 1-naphthyl and 2-naphthyl, each of which is optionally mono-, di-, or tri-substituted, and optionally mono-, di-, or tri-substituted heteroaryl, said heteroaryl having from 1 to 3 rings, 5 to 7 ring members in each ring and, in at least one of said rings, from 1 to about 3 heteroatoms selected from the group consisting of N, O, and S; R is oxygen or absent; Z2 is CR2; Z3 is nitrogen; R1 and R2 are independently chosen from hydrogen, halogen, amino, cyano, nitro, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted mono- or di-alkylamino, optionally substituted cycloalkyl, optionally substituted (cycloalkyl)alkyl, optionally substituted (cycloalkyl)oxy, optionally substituted (cycloalkyl)alkoxy, optionally substituted alkylthio, optionally substituted alkylsulfinyl, optionally substituted alkylsulfonyl, and optionally substituted mono- or dialkylcarboxamide; with the proviso that not all of R1, R3, and R4 are hydrogen. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatments of such disorders and well as packaged pharmaceutical compositions are also provided.Compounds of Formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

公开(公告)号：US20050176721A1

公开(公告)日：2005-08-11

申请号：US11098885

申请日：2005-04-04

申请人： Jianhua Huang ,  Kevin Hodggetts ,  Dario Doller ,  Ping Ge ,  Yasuchika Yamaguchi

发明人： Jianhua Huang ,  Kevin Hodggetts ,  Dario Doller ,  Ping Ge ,  Yasuchika Yamaguchi

IPC分类号： G01N33/566 ,  A61K31/00 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/505 ,  A61K31/5377 ,  A61K51/04 ,  A61P1/04 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D213/74 ,  C07D239/34 ,  C07D241/12 ,  C07D401/04 ,  C07D403/04 ,  C07D405/10 ,  G01N33/58 ,  A61K31/513 ,  C07D43/02

CPC分类号： A61K31/00 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D213/74 ,  C07D241/12 ,  C07D401/04

摘要： Diarylpyrazine, diarylpyridine, and diarylpyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of Formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

摘要翻译： 提供了作为CRF 1受体的选择性调节剂的二芳基吡嗪，二芳基吡啶和二芳基嘧啶化合物。 这些化合物可用于治疗许多中枢神经系统和周围疾病，特别是压力，焦虑，抑郁，心血管疾病和进食障碍。 还提供了治疗这种疾病以及包装的药物组合物的方法。 式I的化合物还可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。 给出了在受体定位研究中使用化合物的方法。