公开(公告)号：US08394914B2

公开(公告)日：2013-03-12

申请号：US12460655

申请日：2009-07-22

申请人： Gregory L. Baker ,  Milton R. Smith, III ,  Erin Vogel

发明人： Gregory L. Baker ,  Milton R. Smith, III ,  Erin Vogel

IPC分类号： C08G63/08

CPC分类号： C08G63/08 ,  A61K9/1075 ,  A61K9/5153 ,  A61K47/34 ,  A61K47/6907 ,  A61K47/6931 ,  A61K47/6935 ,  B82Y5/00 ,  C08G63/6852

摘要： Poly(glycolide) polymers are disclosed. The polymers generally include a glycolide-based polymer backbone that includes one or more functional groups such as alkynyl groups, hydrophilic organic triazole groups, hydrophobic organic triazole groups (also including amphiphilic organic triazole groups), di-triazole organic crosslinking groups, and triazole-substituted drug derivatives. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives. The polymers can further encapsulate a drug for delivery to a patient (i.e., as compared to drug derivatives that are covalently attached to the polymer). The polymers can be in the form of thermodynamically stable unimolecular micelles or crosslinked nanoparticles. The polymer compositions are completely biodegradable and hold great potential for use in biomedical applications.

公开(公告)号：US20090325292A1

公开(公告)日：2009-12-31

申请号：US12460655

申请日：2009-07-22

申请人： Gregory L. Baker ,  Milton R. Smith, III ,  Erin Vogel

发明人： Gregory L. Baker ,  Milton R. Smith, III ,  Erin Vogel

IPC分类号： C12N5/06 ,  C08G63/08 ,  A61K9/00

CPC分类号： C08G63/08 ,  A61K9/1075 ,  A61K9/5153 ,  A61K47/34 ,  A61K47/6907 ,  A61K47/6931 ,  A61K47/6935 ,  B82Y5/00 ,  C08G63/6852

摘要： Poly(glycolide) polymers are disclosed. The polymers generally include a glycolide-based polymer backbone that includes one or more functional groups such as alkynyl groups, hydrophilic organic triazole groups, hydrophobic organic triazole groups (also including amphiphilic organic triazole groups), di-triazole organic crosslinking groups, and triazole-substituted drug derivatives. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives. The polymers can further encapsulate a drug for delivery to a patient (i.e., as compared to drug derivatives that are covalently attached to the polymer). The polymers can be in the form of thermodynamically stable unimolecular micelles or crosslinked nanoparticles. The polymer compositions are completely biodegradable and hold great potential for use in biomedical applications.

摘要翻译： 公开了聚（乙交酯）聚合物。 聚合物通常包括基于乙交酯的聚合物主链，其包括一个或多个官能团，例如炔基，亲水有机三唑基，疏水性有机三唑基团（也包括两亲性有机三唑基团），二 - 三唑有机交联基团和三唑 - 取代的药物衍生物。 炔基提供用于聚合物进一步官能化的反应位点，例如通过与叠氮化物衍生物反应。 聚合物可以进一步包封用于递送给患者的药物（即，与共价连接到聚合物上的药物衍生物相比）。 聚合物可以是热力学稳定的单分子胶束或交联纳米颗粒的形式。 聚合物组合物是完全可生物降解的，并且具有用于生物医学应用的巨大潜力。