公开(公告)号：US20110212414A1

公开(公告)日：2011-09-01

申请号：US13059847

申请日：2009-08-19

申请人： Takashi Tsuji ,  Etsuko Ikeda ,  Hiroaki Asai

发明人： Takashi Tsuji ,  Etsuko Ikeda ,  Hiroaki Asai

IPC分类号： A61C8/00 ,  C12N5/077

CPC分类号： A61L27/3834 ,  A61L27/3813 ,  A61L27/3865 ,  A61L27/3891

摘要： A method of producing a restorative material used to restore a tooth-deficient area in an oral cavity, the method comprising: positioning, in a support carrier, a first cell mass formed from either mesenchymal cells or epithelial cells and a second cell mass formed from the other of the mesenchymal cells or epithelial cells, one of the mesenchymal cells or epithelial cells being derived from a tooth germ and the first and second cell masses being not mixed with each other but made to closely contact each other; culturing the first and second cell masses to form a reconstructed tooth germ or tooth; and confirming directionality of the reconstructed tooth germ or tooth formed by the culturing so as to enable the reconstructed tooth germ or tooth to be embedded in the tooth-deficient area such that a tip of the tooth faces an interior of the oral cavity, the tooth germ or tooth whose directionality has been confirmed being used as a restorative material to obtain an equivalent of a missing tooth in the tooth-deficient area. A method for restoring a tooth-deficient area, the method comprising; embedding the reconstructed tooth germ or tooth obtained by the production method in the tooth-deficient area.

摘要翻译： 一种生产用于恢复口腔缺牙区域的修复材料的方法，所述方法包括：在载体载体中定位由间充质细胞或上皮细胞形成的第一细胞块和由 间质细胞或上皮细胞中的另一个，间充质细胞或上皮细胞之一来自牙胚，第一和第二细胞团彼此不混合但彼此紧密接触; 培养第一和第二细胞块以形成重建的牙胚或牙齿; 并且确定通过培养形成的重建牙胚或牙齿的方向性，以使重建的牙胚或牙齿能够嵌入牙齿缺损区域，使得牙齿的尖端面向口腔内部，牙齿 确定其方向性的胚芽或牙齿用作修复材料以获得缺牙区域中缺失牙齿的当量。 一种用于恢复牙缺陷区域的方法，所述方法包括： 将通过生产方法获得的重建牙胚或牙齿嵌入牙缺陷区域。