公开(公告)号：US20190209734A1

公开(公告)日：2019-07-11

申请号：US16353834

申请日：2019-03-14

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Helen H. LU ,  Sagaw PRATEEPCHINDA ,  Gunnar HASSELGREN ,  Dror SELIKTAR

IPC: A61L27/22 ,  A61L27/38 ,  A61K35/32 ,  A61L27/26 ,  A61L27/52 ,  A61K35/28 ,  A61L27/48 ,  A61L27/58 ,  C12N5/0775 ,  A61L27/16 ,  A61L27/18 ,  A61K9/06 ,  A61K9/00 ,  A61L27/54

CPC classification number: A61L27/225 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/28 ,  A61K35/32 ,  A61L27/16 ,  A61L27/18 ,  A61L27/26 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3865 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/406 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/12 ,  C12N5/0664 ,  C12N2533/50 ,  C08L89/00 ,  C08L71/02

Abstract: Hydrogel-based scaffolds useful for promoting pulp cell growth and biosynthesis, regulating pulp cell migration and morphology, or both as well as methods for their production and use are provided.

公开(公告)号：US09724368B2

公开(公告)日：2017-08-08

申请号：US14102295

申请日：2013-12-10

Applicant: NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY

Inventor： Misako Nakashima ,  Koichiro Iohara

IPC: A61L27/36 ,  A61L27/38 ,  C12N5/0775 ,  A61K38/19 ,  A61K35/32 ,  A61C5/50 ,  A61K35/28

CPC classification number: A61K35/28 ,  A61C5/50 ,  A61K35/32 ,  A61K38/193 ,  A61L27/3633 ,  A61L27/3834 ,  A61L27/3865 ,  A61L2430/12 ,  C12N5/0664 ,  A61K2300/00

Abstract: Disclosed is a root canal filler for non-extracted tooth which causes no internal resorption or external resorption in a tooth with complete root formation, shows no odontoclast, and contributes to the regeneration of a dental tissue in which odontoblasts are smoothly aligned on the dentin wall. After pulpectomy or enlargement/cleaning of an infected root canal, a root canal filler for non-extracted tooth, which comprises tooth pulp stem cells and an extracellular matrix, is inserted into the apical side of the root canal of the non-extracted tooth. The tooth pulp stem cells may be, for example, dental pulp CXCR4-positive cells. It is preferred to attach, to the crown side of the root canal, migration factor(s) including at least one factor selected from among a cell migration factor, a cell proliferation factor, a neurotrophic factor and an angiogenic factor.

公开(公告)号：US20170156824A1

公开(公告)日：2017-06-08

申请号：US15439105

申请日：2017-02-22

Applicant: Natural Dental Implants, AG

Inventor： Ruedger Rubbert ,  Ernst-Ulrich Berndt ,  Jakob Sebastian Marquard ,  Hauke Schmidt-Martens ,  Lea Ellermeier Nesbit

IPC: A61C8/00 ,  A61L27/16 ,  A61C13/107 ,  A61C13/00 ,  A61C19/10

CPC classification number: A61C8/0036 ,  A61C5/007 ,  A61C5/30 ,  A61C8/0006 ,  A61C8/0009 ,  A61C8/0012 ,  A61C8/0013 ,  A61C8/0015 ,  A61C8/0018 ,  A61C8/0068 ,  A61C8/0075 ,  A61C8/0077 ,  A61C9/0046 ,  A61C13/0001 ,  A61C13/0004 ,  A61C13/0006 ,  A61C13/0013 ,  A61C13/0018 ,  A61C13/0019 ,  A61C13/0022 ,  A61C13/0028 ,  A61C13/082 ,  A61C19/063 ,  A61C19/10 ,  A61L27/025 ,  A61L27/08 ,  A61L27/16 ,  A61L27/3804 ,  A61L27/3865 ,  A61L2430/12

Abstract: Custom dental prosthesis or implants each individually designed and manufactured to replace nonfunctional natural teeth positioned in a jawbone of a specific pre-identified patient are provided. An example dental prosthesis/implant includes a dental implant body having a prosthesis interface formed therein to receive an occlusally-facing dental prosthesis component. The prosthesis interface has a custom three-dimensional surface shape positioned and formed to create a form locking fit with respect to the occlusally-facing dental prosthesis component when positioned thereon.

公开(公告)号：US20170128172A1

公开(公告)日：2017-05-11

申请号：US15318568

申请日：2015-06-19

Applicant: 3-D MATRIX, LTD. ,  Forsyth Dental Infirmary for Children

Inventor： Lisa Spirio ,  Hatice Hasturk ,  Thomas E. Van Dyke

IPC: A61C8/00 ,  A61C19/06 ,  A61L27/38 ,  A61L27/22 ,  A61L27/10 ,  A61L27/54 ,  A61C8/02 ,  A61L27/52

CPC classification number: A61C8/0092 ,  A61C8/0006 ,  A61C19/063 ,  A61L27/10 ,  A61L27/227 ,  A61L27/3865 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/12

Abstract: Materials and methods for dental bone void filling such as during a sinus lift procedure are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.

公开(公告)号：US20170086953A1

公开(公告)日：2017-03-30

申请号：US15376051

申请日：2016-12-12

Applicant: Natural Dental Implants AG

Inventor： Ruedger Rubbert ,  Ernst-Ulrich Berndt ,  Jakob Sebastian Marquard ,  Hauke Schmidt-Martens ,  Lea Ellermeier Nesbit

IPC: A61C13/00 ,  A61C13/08 ,  A61C9/00 ,  A61C8/02 ,  A61C8/00

CPC classification number: A61C5/30 ,  A61C8/0006 ,  A61C8/0012 ,  A61C8/0018 ,  A61C8/0036 ,  A61C8/0048 ,  A61C8/0075 ,  A61C9/0046 ,  A61C13/0004 ,  A61C13/0013 ,  A61C13/0019 ,  A61C13/082 ,  A61K6/0044 ,  A61L27/3804 ,  A61L27/3865 ,  A61L2430/12 ,  G16H20/40

Abstract: Methods of manufacturing dental prosthesis/implants each to replace a non-functional natural tooth positioned in a jawbone of a specific pre-identified patient are provided. An example method includes the steps of receiving imaging data such as x-ray image data and surface scan data of a dental anatomy and/or a physical impression of the dental anatomy of a specific preidentified patient. The steps can also include forming a three-dimensional virtual model of at least portions of a non-functional natural tooth positioned in the jawbone of the specific pre-identified patient based on the imaging and surface scan data, virtually designing a dental implant based upon the virtual model, exporting the data describing the designed dental implant to a manufacturing machine, and custom manufacturing the dental implant for the specific patient.

公开(公告)号：US20140356797A1

公开(公告)日：2014-12-04

申请号：US14375715

申请日：2013-01-28

Applicant: Organ Technologies, Inc.

Inventor： Takashi Tsuji ,  Masamitsu Oshima

IPC: A61C8/00 ,  A61K6/033 ,  A61D5/00

CPC classification number: A61C8/0013 ,  A61D5/00 ,  A61K6/0038 ,  A61K6/0044 ,  A61K6/0085 ,  A61K6/033 ,  A61L27/32 ,  A61L27/34 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3865 ,  A61L2430/12 ,  C08L89/06

Abstract: The purpose of the present invention is to provide a dental implant which enables the formation of a functional periodontal tissue around the implant after the implantation of the implant. The dental implant according to the present invention is characterized in that a cell mass originated from a tooth germ tissue or a periodontal ligament tissue is placed on the surface of the implant and the surface of the implant on which the cell mass is to be placed is the whole or a part of a surface that is surrounded by an alveolar bone of a recipient during the implantation of the implant.

Abstract translation: 本发明的目的是提供一种牙植入物，其能够在植入物植入之后在植入物周围形成功能性牙周组织。 根据本发明的牙科植入物的特征在于，源自牙胚组织或牙周韧带组织的细胞质量被放置在植入物的表面上，并且待放置细胞块的植入物的表面是 在植入物植入期间由受体的牙槽骨包围的表面的整个或一部分。

公开(公告)号：US08344042B2

公开(公告)日：2013-01-01

申请号：US12633708

申请日：2009-12-08

Applicant: Gao Liu ,  Dacheng Zhao ,  Eduardo Saiz ,  Antoni P. Tomsia

Inventor： Gao Liu ,  Dacheng Zhao ,  Eduardo Saiz ,  Antoni P. Tomsia

IPC: A61L24/06 ,  C08K3/32 ,  C08F261/06 ,  A61F2/28 ,  C08G63/08

CPC classification number: C12N5/0654 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3865 ,  A61L27/46 ,  A61L27/52 ,  A61L2430/02 ,  C12N2533/18 ,  C12N2533/30

Abstract: The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Abstract translation: 本发明提供了包含可生物降解的水凝胶聚合物支架的可生物降解的合成骨组合物，其包含多个水解不稳定的键和无机组分; 例如可生物降解的聚甲基丙烯酸羟乙酯/羟基磷灰石（pHEMA / HA）水凝胶复合材料，其矿物质含量大约为人骨的含量。

公开(公告)号：US20120040907A1

公开(公告)日：2012-02-16

申请号：US13280411

申请日：2011-10-25

Applicant: Anthony T. DiBenedetto ,  Samuel Jien-shek Huang ,  Claudio Migliaresi ,  Antonella Motta

Inventor： Anthony T. DiBenedetto ,  Samuel Jien-shek Huang ,  Claudio Migliaresi ,  Antonella Motta

IPC: A61K38/17 ,  A61P17/02 ,  A61P19/10 ,  A61P19/00

CPC classification number: A61L27/3604 ,  A61L24/0084 ,  A61L24/0094 ,  A61L24/108 ,  A61L26/0047 ,  A61L26/0095 ,  A61L27/227 ,  A61L27/365 ,  A61L27/3847 ,  A61L27/3865 ,  A61L27/46 ,  A61L27/48

Abstract: A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues. The fibroin solutions and suspensions are particularly useful for methods of tissue construction and/or repair.

Abstract translation: 使用丝心蛋白溶液和悬浮液制备生物活性物质，其设计用于支持骨骼和身体的其他组织的构造，修复，再生或增加。 可以注射丝心蛋白溶液，悬浮液和复合材料以填充空腔或替代缺失的组织。 注射后，材料可以产生能够在降解的同时促进组织再生的支架。 注射丝心蛋白溶液，悬浮液和复合材料的能力可以减少用于更换或修复骨骼和其他组织的许多类型的外科手术的需要。 丝心蛋白溶液和悬浮液对于组织结构和/或修复的方法特别有用。

公开(公告)号：US20110117521A1

公开(公告)日：2011-05-19

申请号：US12622108

申请日：2009-11-19

Applicant: Jyrki Törnvall ,  Bettina Lindroos ,  Marjo-Riitta Suuronen ,  Susanna Miettinen ,  Karri Mesimäki ,  Jari Mauno

Inventor： Jyrki Törnvall ,  Bettina Lindroos ,  Marjo-Riitta Suuronen ,  Susanna Miettinen ,  Karri Mesimäki ,  Jari Mauno

IPC: A61F2/28 ,  C12N5/071 ,  C12N5/077 ,  A61C8/00

CPC classification number: A61C8/0006 ,  A61F2/2803 ,  A61F2/2875 ,  A61F2/4644 ,  A61F2002/2889 ,  A61F2002/4648 ,  A61F2310/00023 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3865 ,  C12N5/0667

Abstract: The present invention relates to the field of microvascular reconstruction surgery of bone defects. More specifically, the invention relates to a biological jaw regenerate and to methods of preparing said jaw regenerate. Furthermore, the invention relates to a method of reconstructing a jaw defect in a patient in need thereof.

Abstract translation: 本发明涉及骨缺损的微血管重建手术领域。 更具体地，本发明涉及一种生物颚式再生物，以及制备所述颚式再生的方法。 此外，本发明涉及一种在有需要的患者中重建颌缺损的方法。

公开(公告)号：US07497686B2

公开(公告)日：2009-03-03

申请号：US11171965

申请日：2005-06-30

Applicant: Paul Thomas Sharpe ,  Michael David Leek ,  Paul David Kemp ,  Ewan James Campbell

Inventor： Paul Thomas Sharpe ,  Michael David Leek ,  Paul David Kemp ,  Ewan James Campbell

IPC: A61C5/00

CPC classification number: A61L27/3804 ,  A61K35/12 ,  A61L27/3604 ,  A61L27/3865 ,  A61L27/3895 ,  A61L2430/02 ,  C12N5/0606 ,  C12N5/0623 ,  C12N5/0663

Abstract: The present invention is based on the discovery that when a tooth primordium is inserted into a mammalian jaw and tooth formation follows, new alveolar bone around the new tooth forms. The present invention is based on the idea of stimulating new tooth formation via the implantation of tooth primordia at selected places in the jaw (e.g. at four points in the molar regions) to result in the formation of bony protuberances which could facilitate denture retention. The teeth may then be removed from the jaw of the patient to leave the new alveolar bone.

Abstract translation: 本发明基于以下发现：当牙根原基插入到哺乳动物颌部并且牙齿形成时，新牙齿周围的新牙槽骨形成。 本发明基于通过在钳口中的选定位置（例如，在摩擦区域中的四个点）植入牙齿原基来刺激新牙齿形成的想法，以导致形成可以促进义齿保留的骨突起物。 然后可以从患者的颌骨上移除牙齿以离开新的牙槽骨。