公开(公告)号：US4100267A

公开(公告)日：1978-07-11

申请号：US618644

申请日：1975-10-01

申请人： Eugene Douglas Shaw

发明人： Eugene Douglas Shaw

IPC分类号： A61K39/00 ,  A61K39/29 ,  C07K14/02 ,  G01N33/564 ,  G01N33/576 ,  A61K39/42 ,  A61K43/00 ,  G01N31/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/29 ,  G01N33/576 ,  A61K39/00 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2770/32422 ,  C12N2770/32434 ,  Y10S436/82

摘要： The formation of antibodies to the A-2 plaque virus previously propagated in tissue culture is described. The application describes an immune response against those antibodies and against the A-2 plaque virus antigen which is associated with human viral hepatitis both of type A and B origin. The reaction of antibody for A-2 plaque virus with the antigen from stool specimens of volunteers infected with type A hepatitis and from the sera of patients diagnosed as having type B hepatitis is described. Convalescent sera from both type A and type B hepatitis patients in reaction with the virus, demonstrate the presence of antigenic components in the plaque virus which react with human antibody formed in response to infection with either type A or type B hepatitis. Moreover, the A-2 plaque antibodies react with hepatitis B core antigen, while antibodies to HB.sub.c Ag react with A-2 plaque antigen. Additionally, methods for inducing antibody formation in humans from the A-2 plaque virus antigen are described, as are methods for detecting HB.sub.c Ag, HB.sub.c Ab, HAAg and HAAb.

摘要翻译： 描述了先前在组织培养中传播的对A-2斑块病毒的抗体的形成。 该应用描述了针对A型和B型来源的人类病毒性肝炎相关的针对这些抗体和针对A-2斑块病毒抗原的免疫应答。 描述了A-2斑块病毒抗体与感染A型肝炎的志愿者粪便标本和诊断为B型肝炎的患者血清的抗原反应。 A型和B型肝炎患者与病毒反应的恢复期血清证实在与A型或B型肝炎感染反应形成的人类抗体相互作用的斑块病毒中存在抗原成分。 此外，A-2斑块抗体与乙型肝炎核心抗原反应，而HBcAg的抗体与A-2斑块抗原反应。 此外，还描述了从A-2斑块病毒抗原诱导人的抗体形成的方法，以及用于检测HBcAg，HBcAb，HAAg和HAAb的方法。