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公开(公告)号：US4656159A
公开(公告)日：1987-04-07
申请号：US666904
申请日：1984-10-31
申请人： Eugene McPherson , Philip S. Schein
发明人： Eugene McPherson , Philip S. Schein
IPC分类号： C12N5/06 , A61K31/70 , A61K31/7008 , A61K31/7024 , A61K31/7028 , A61P35/00 , A61P35/02 , C07H5/06 , C07H9/02 , C07H9/04 , C07H13/04 , C07H15/12
摘要： Compounds of the formula ##STR1## wherein X is halogen; each R independently represents H, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.4 alkanoyl group, a phosphate group, or a sulfate, sulfonate, or benzoate group with the proviso that no more than one sulfate, sulfonate, or benzoate group is present in said compound; and R' represents R or a carbohydrate residue derived from a carbohydrate having the formula R'OH with the proviso that R' and the R on C-2 or both R groups on C-3 and C-4 together can represent an isopropylidene group; or a pharmaceutically acceptable salt thereof, are disclosed along with methods of synthesizing and using these compounds.
摘要翻译： 式（Ⅰ）化合物，其中X是卤素; 每个R独立地表示H，C1-C4烷基，C2-C4烷酰基，磷酸基或硫酸根，磺酸根或苯甲酸根，条件是不超过一个硫酸根，磺酸根或苯甲酸根存在 在所述化合物中; 并且R'表示R或衍生自具有式R'OH的碳水化合物的碳水化合物残基，条件是R'和C-2上的R或C-3和C-4上的两个R基团可以一起代表异丙叉基 ; 或其药学上可接受的盐以及合成和使用这些化合物的方法。
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公开(公告)号：US4720543A
公开(公告)日：1988-01-19
申请号：US742045
申请日：1985-06-06
申请人： Eugene McPherson , Philip S. Schein
发明人： Eugene McPherson , Philip S. Schein
IPC分类号： C07H15/26 , C07D487/14 , A61K31/40
CPC分类号： C07H15/26 , Y10S514/908
摘要： This invention discloses 1a- and 7-substituted derivatives of mitosanes containing thiocarbamoyl and glycosyl residues. The compounds possess antibacterial and antitumor activity, with a concomitant reduction in bone marrow toxicity as compared to the parent compounds.
摘要翻译： 本发明公开了含有硫代氨基甲酰基和糖基残基的丝裂原的1a-和7-取代衍生物。 与母体化合物相比，该化合物具有抗细菌和抗肿瘤活性，伴随着骨髓毒性的降低。
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