公开(公告)号：US20130323183A1

公开(公告)日：2013-12-05

申请号：US13985219

申请日：2012-02-13

申请人： Andrea Pastorello ,  Devis Galesso ,  Fabio Bettella

发明人： Andrea Pastorello ,  Devis Galesso ,  Fabio Bettella

IPC分类号： A61K31/738 ,  A61K31/196 ,  A61K45/06 ,  A61K33/38 ,  A61K31/728

CPC分类号： A61K31/738 ,  A61K9/0014 ,  A61K9/146 ,  A61K31/192 ,  A61K31/196 ,  A61K31/717 ,  A61K31/728 ,  A61K31/729 ,  A61K33/38 ,  A61K45/06 ,  A61K2300/00

摘要： The invention discloses pharmaceutical compositions in the form of a dusting powder or dry spray, possessing a high absorbent capacity, painkilling activity and wound-healing action, which compositions consist of croscarmellose sodium, a non-steroidal anti-inflammatory drug (NSAID) and hyaluronic acid, and optionally also contain other pharmacologically active substances and/or excipients. The compositions disclosed herein are suitable for use in the treatment of skin lesions wherein the presence of exudate limits wound healing and causes pain; they are therefore particularly suitable for chronic ulcerous skin lesions of various origins and burns.

摘要翻译： 本发明公开了具有高吸收能力，止痛活性和伤口愈合作用的粉剂或干喷雾形式的药物组合物，该组合物由交联羧甲纤维素钠，非甾体抗炎药（NSAID）和透明质酸 酸，并且任选地还含有其它药理活性物质和/或赋形剂。 本文公开的组合物适用于治疗皮肤病变，其中渗出液的存在限制伤口愈合并引起疼痛; 因此它们特别适用于各种起源和灼伤的慢性溃疡性皮肤病变。

公开(公告)号：US08992890B2

公开(公告)日：2015-03-31

申请号：US13985219

申请日：2012-02-13

申请人： Andrea Pastorello ,  Devis Galesso ,  Fabio Bettella

发明人： Andrea Pastorello ,  Devis Galesso ,  Fabio Bettella

IPC分类号： A61K31/738 ,  A61K31/192 ,  A61K31/196 ,  A61K31/717 ,  A61K31/729 ,  A61K33/38 ,  A61K45/06 ,  A61K9/00 ,  A61K9/14 ,  A61K31/728

CPC分类号： A61K31/738 ,  A61K9/0014 ,  A61K9/146 ,  A61K31/192 ,  A61K31/196 ,  A61K31/717 ,  A61K31/728 ,  A61K31/729 ,  A61K33/38 ,  A61K45/06 ,  A61K2300/00

摘要： The invention discloses pharmaceutical compositions in the form of a dusting powder or dry spray, possessing a high absorbent capacity, painkilling activity and wound-healing action, which compositions consist of croscarmellose sodium, a non-steroidal anti-inflammatory drug (NSAID) and hyaluronic acid, and optionally also contain other pharmacologically active substances and/or excipients. The compositions disclosed herein are suitable for use in the treatment of skin lesions wherein the presence of exudate limits wound healing and causes pain; they are therefore particularly suitable for chronic ulcerous skin lesions of various origins and burns.

摘要翻译： 本发明公开了具有高吸收能力，止痛活性和伤口愈合作用的粉剂或干喷雾形式的药物组合物，该组合物由交联羧甲纤维素钠，非甾体抗炎药（NSAID）和透明质酸 酸，并且任选地还含有其它药理活性物质和/或赋形剂。 本文公开的组合物适用于治疗皮肤病变，其中渗出液的存在限制伤口愈合并引起疼痛; 因此它们特别适用于各种起源和灼伤的慢性溃疡性皮肤病变。

公开(公告)号：US20080292703A1

公开(公告)日：2008-11-27

申请号：US11989716

申请日：2006-08-02

申请人： Davide Renier ,  Fabio Bettella

发明人： Davide Renier ,  Fabio Bettella

IPC分类号： A61K9/00 ,  A61K31/715 ,  A61K9/14 ,  A61P35/04

CPC分类号： A61K47/4823 ,  A61K47/61

摘要： The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.

摘要翻译： 本发明描述了一组新的生物缀合物，其可以通过间接合成，通过分子间隔物，透明质酸和/或其衍生物和具有属于不同组的抗肿瘤活性的药物，其制备方法和在 肿瘤领域。 关于债券和替代程度的新衍生物具有不同的物理化学性质，其改善其耐受性和效率，并允许更准确地调节剂量，利用主动靶向机制。

公开(公告)号：US09687558B2

公开(公告)日：2017-06-27

申请号：US11989716

申请日：2006-08-02

申请人： Davide Renier ,  Fabio Bettella

发明人： Davide Renier ,  Fabio Bettella

IPC分类号： A61K47/48

CPC分类号： A61K47/4823 ,  A61K47/61

摘要： The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.