公开(公告)号：US20120154817A1

公开(公告)日：2012-06-21

申请号：US13319269

申请日：2010-04-24

申请人： Stefan Walheim ,  Thomas Schimmel ,  Steven Lenhert ,  Harald Fuchs ,  Falko Brinkmann ,  Thomas Laue

发明人： Stefan Walheim ,  Thomas Schimmel ,  Steven Lenhert ,  Harald Fuchs ,  Falko Brinkmann ,  Thomas Laue

IPC分类号： G01N21/55

CPC分类号： G01N33/54373

摘要： A method for detecting the presence of molecules includes bringing into contact with at least one optical grating comprised of a first liquid phase, a second liquid phase which cannot be mixed with the first liquid phase. The first liquid phase is arranged on a substrate in a form of periodic structures having a periodicity ranging from about 190 nm to about 10 μm. The molecules to be detected, which are capable of changing the optical characteristics of the at least one optical grating are added to the first liquid phase or to the second liquid phase either before, during or after the bringing step. The presence of molecules is detected by measuring a changed reflection or transmission of light at the at least one optical grating or a changing spatial course of the diffraction pattern as soon as the first liquid phase makes contact with the second liquid phase and with the molecules to be detected.

摘要翻译： 用于检测分子存在的方法包括与至少一个光栅相接触，该光栅由第一液相，不能与第一液相混合的第二液相组成。 第一液相以周期性结构的形式布置在基板上，周期性范围为约190nm至约10μm。 能够改变至少一个光栅的光学特性的待检测分子在引入步骤之前，期间或之后被添加到第一液相或第二液相。 分子的存在通过在第一液相与第二液相接触并且分子到达时测量在至少一个光栅上的光的改变的反射或透射或衍射图的改变的空间过程来检测 被检测。

公开(公告)号：US08780351B2

公开(公告)日：2014-07-15

申请号：US13319269

申请日：2010-04-24

申请人： Stefan Walheim ,  Thomas Schimmel ,  Steven Lenhert ,  Harald Fuchs ,  Falko Brinkmann ,  Thomas Laue

发明人： Stefan Walheim ,  Thomas Schimmel ,  Steven Lenhert ,  Harald Fuchs ,  Falko Brinkmann ,  Thomas Laue

IPC分类号： G01N21/00 ,  G01N21/55

CPC分类号： G01N33/54373

摘要： A method for detecting the presence of molecules includes bringing into contact with at least one optical grating comprised of a first liquid phase, a second liquid phase which cannot be mixed with the first liquid phase. The first liquid phase is arranged on a substrate in a form of periodic structures having a periodicity ranging from about 190 nm to about 10 μm. The molecules to be detected, which are capable of changing the optical characteristics of the at least one optical grating are added to the first liquid phase or to the second liquid phase either before, during or after the bringing step. The presence of molecules is detected by measuring a changed reflection or transmission of light at the at least one optical grating or a changing spatial course of the diffraction pattern as soon as the first liquid phase makes contact with the second liquid phase and with the molecules to be detected.

摘要翻译： 用于检测分子存在的方法包括与至少一个光栅相接触，该光栅由第一液相，不能与第一液相混合的第二液相组成。 第一液相以周期性结构的形式布置在基板上，周期性范围为约190nm至约10μm。 能够改变至少一个光栅的光学特性的待检测分子在引入步骤之前，期间或之后被添加到第一液相或第二液相。 分子的存在通过在第一液相与第二液相接触并且分子到达时测量在至少一个光栅上的光的改变的反射或透射或衍射图的改变的空间过程来检测 被检测。