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公开(公告)号:US07432245B2
公开(公告)日:2008-10-07
申请号:US10456831
申请日:2003-06-06
申请人: Fortuna Haviv , Bryan K. Erickson , Jack Henkin , Luk C. Li , Fanfeng Ma , Friedrich W. Richter , Yi Shi , Jingfeng Song , Siriporn Toongsuwan
发明人: Fortuna Haviv , Bryan K. Erickson , Jack Henkin , Luk C. Li , Fanfeng Ma , Friedrich W. Richter , Yi Shi , Jingfeng Song , Siriporn Toongsuwan
摘要: Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.
摘要翻译: 公开了可用于持续释放的肽的肠胃外制剂。 还公开了制剂的制备方法。
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公开(公告)号:US5750665A
公开(公告)日:1998-05-12
申请号:US539292
申请日:1995-10-04
申请人: Gerald J. Vosika , Fanfeng Ma
发明人: Gerald J. Vosika , Fanfeng Ma
IPC分类号: C07H15/23 , A61K31/7012 , A61K38/00 , A61P37/02 , C07H15/00 , C07H15/04 , C07H15/18 , C07K5/062 , C07K9/00 , C07H5/00
摘要: The present invention provides a method for the preparation of disaccharides, such as glucosaminyl muramic acids peptides and derivatives. The method includes condensing a protected muramic acid ester with a 1-organothio- or 1-fluoroglucosamine derivative in the presence of a suitable promoter to produce a protected glucosaminyl muramic acid ester. The protected glucosaminyl muramic acid ester may be used to prepare disaccharide peptides, such as N-acetylglucosaminyl-N-acetylmuramyl dipeptides, which have demonstrated immunological activity. Protected muramic acid esters and 1-organothio- or 1-fluoro- glucosamine compounds which may be employed as intermediates in the method are also provided.
摘要翻译: 本发明提供了制备二糖的方法,例如葡糖胺基胞壁酰胺酸肽和衍生物。 该方法包括在合适的启动子存在下将保护的间硅酸酯与1-有机硫代或1-氟葡糖胺衍生物缩合,以产生受保护的氨基葡糖胺基胞壁酸酯。 可以使用保护的氨基葡糖基胞壁酸酯来制备已证明具有免疫活性的二糖肽,例如N-乙酰葡糖胺基-N-乙酰基胞壁酰二肽。 还提供了可用作该方法中的中间体的受保护的胞壁酸酯和1-有机硫代 - 或1-氟 - 葡糖胺化合物。
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公开(公告)号:US20180160709A1
公开(公告)日:2018-06-14
申请号:US15836818
申请日:2017-12-08
申请人: Zhongyuan Zhu , Fanfeng Ma , Mu Zhu , Xiyuan Zhu
发明人: Zhongyuan Zhu , Fanfeng Ma , Mu Zhu , Xiyuan Zhu
CPC分类号: A23L27/86 , A23L27/20 , A23V2002/00 , A61K9/0056 , A61K9/0058 , A61K9/006 , A61K9/0095 , A61K38/47
摘要: The current invention relates to a gargle dosage formulation and a method for removing the bitter taste in oral medication or food. Particularly, this bitter-removal formulation comprises at least one of two preparations, the first preparation and the second preparation. The current invention also discloses a method of using the preparations before and after taking oral medication or food. Right before taking oral medication or food, the first preparation is used to gargle the user's oral cavity. After it is spat out, the first preparation forms a thin layer on the surface of the oral mucosa to cover, shield, and protect taste buds from the direct contact with oral medication or food. Immediately after oral medication or food is taken, the second preparation is used to gargle and clean the user's taste buds, which effectively elutes mucosa-binding bitter ingredients from the oral cavity. Because both preparations are spat out, there is neither body intake of these preparations nor interference to the oral medication. The gargle preparation can be generally used with various types of oral medication. Both preparations in this formulation are simple, safe, inexpensive, and easy to use. The first and second preparations may be used together or only one of them is used. The gargle preparation is very effective to minimize and remove tastes such as the bitter taste, peculiar taste, and dulled taste, which are associated with the traditional herbal medicine such as traditional Chinese herbs and their decoctions. The gargle preparation helps patients who are taking oral medication with the bitter taste to maintain healthy taste buds and improve life quality.
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公开(公告)号:US6008333A
公开(公告)日:1999-12-28
申请号:US30138
申请日:1998-02-25
申请人: Gerald J. Vosika , Fanfeng Ma
发明人: Gerald J. Vosika , Fanfeng Ma
IPC分类号: C07H15/23 , A61K31/7012 , A61K38/00 , A61P37/02 , C07H15/00 , C07H15/04 , C07H15/18 , C07K5/062 , C07K9/00
摘要: The present invention provides a method for the preparation of disaccharides, such as glucosaminyl muramic acids peptides and derivatives. The method includes condensing a protected muramic acid ester with a 1-organothio- or 1-fluoroglucosamine derivative in the presence of a suitable promoter to produce a protected glucosaminyl muramic acid ester. The protected glucosaminyl muramic acid ester may be used to prepare disaccharide peptides, such as N-acetylglucosaminyl-N-acetylmuramyl dipeptides, which have demonstrated immunological activity. Protected muramic acid esters and 1-organothio- or 1-fluoro-glucosamine compounds which may be employed as intermediates in the method are also provided.
摘要翻译: 本发明提供了制备二糖的方法,例如葡糖胺基胞壁酰胺酸肽和衍生物。 该方法包括在合适的启动子存在下将保护的间硅酸酯与1-有机硫代或1-氟葡糖胺衍生物缩合,以产生受保护的氨基葡糖胺基胞壁酸酯。 可以使用保护的氨基葡糖基胞壁酸酯来制备已证明具有免疫活性的二糖肽,例如N-乙酰葡糖胺基-N-乙酰基胞壁酰二肽。 还提供了可用作该方法中的中间体的受保护的胞壁酸酯和1-有机硫代 - 或1-氟 - 葡糖胺化合物。
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