公开(公告)号：US20220241820A1

公开(公告)日：2022-08-04

申请号：US17611866

申请日：2020-05-13

申请人： Felix Trampler

发明人： Felix Trampler

IPC分类号： B06B1/20 ,  B01D21/28

摘要： Various embodiments of the present disclosure are directed to a device and a method for producing a standing ultrasonic field having the frequency f in a liquid. In one example embodiment, the device includes at least one oscillation element, a substantially dimensionally stable vessel having an outside wall and a substantially circular-cylindrical interior, the vessel receiving the liquid and the at least one oscillation element. The at least one oscillation element acoustically connected to the outside wall of the vessel and electrically excited at the frequency f. The substantially circular-cylindrical interior receives liquid with an inner radius ro at least in the region of the oscillation element. The oscillation element has a mean thickness p and a width b in the direction orthogonal to a main axis of the interior, and the width b is not greater than the inner diameter 2ro.

公开(公告)号：US5527460A

公开(公告)日：1996-06-18

申请号：US86700

申请日：1993-07-02

申请人： Felix Trampler ,  Ewald Benes ,  Wolfgang Burger ,  Martin Groschl

发明人： Felix Trampler ,  Ewald Benes ,  Wolfgang Burger ,  Martin Groschl

IPC分类号： B01D21/00 ,  B01D43/00 ,  B01J19/10 ,  C02F1/36

CPC分类号： B01D21/283 ,  B01D43/00 ,  B01J19/10

摘要： Particulate material suspended in a fluid is separated and recycled by means of an ultrasonic resonance wave. In a preferred embodiment, the ultrasonic resonance field is generated within a multilayered composite resonator system including a transducer, the suspension and a mirror parallel to each other. Dimensions and frequencies resonant to the whole system but not exciting Eigen-frequencies of transducer and mirror itself are chosen so that thermal dissipation is minimized. Generally, the process is suitable for all kinds of particles (solid, liquid or gaseous disperse phases) especially for hydrosols (particles in water) and for separation of biological particles such as mammalian, bacterial and plant cells or aggregates. Specialized applications in biotechnology are described including an acoustic filter for mammalian cell bioreactors or the selective retention of viable cells relative to non-viable cells.

摘要翻译： 悬浮在流体中的颗粒物质通过超声共振波被分离和循环。 在优选实施例中，在包括换能器，悬架和彼此平行的反射镜的多层复合谐振器系统内产生超声共振场。 尺寸和频率与整个系统共振但不激励选择换能器和反射镜本征频率，以使散热最小化。 通常，该方法适用于各种颗粒（固体，液体或气体分散相），特别是用于水溶胶（水中的颗粒）和分离生物颗粒如哺乳动物，细菌和植物细胞或聚集体。 描述了生物技术中的专门应用，包括用于哺乳动物细胞生物反应器的声学过滤器或相对于非活细胞选择性保留活细胞。

公开(公告)号：US20060037916A1

公开(公告)日：2006-02-23

申请号：US11206105

申请日：2005-08-18

申请人： Felix Trampler

发明人： Felix Trampler

IPC分类号： C02F1/32

CPC分类号： B01D49/006 ,  B01D21/2433 ,  B01D21/245 ,  B01D21/283 ,  B01D43/00 ,  B01D2221/10

摘要： The invention relates to an apparatus for separating dispersed particles or similar particles (4), comprising a separating vessel (1) which is provided with at least one transducer (2) for generating ultrasonic waves in the form of a wave with substantially perpendicularly extending oscillation node surfaces, an inlet opening (3) for the dispersion, an outlet opening (6) for the liquid medium and a discharge opening (5) for the separated particles. An effective separation can be achieved in such a way that the separating vessel (1) contains a separating surface (7, 8, 9) which is inclined at an acute angle (α) relative to the horizontal in the used position.

摘要翻译： 本发明涉及一种用于分离分散颗粒或类似颗粒（4）的装置，包括分离容器（1），该分离容器设有至少一个换能器（2），用于产生呈波浪形式的超声波，其基本垂直延伸的振荡 节点表面，用于分散体的入口（3），用于液体介质的出口（6）和用于分离的颗粒的排出口（5）。 可以以分离容器（1）包含在使用位置相对于水平面以锐角（α）倾斜的分离表面（7,8,9）的方式实现有效的分离。

公开(公告)号：US5711888A

公开(公告)日：1998-01-27

申请号：US627433

申请日：1996-04-04

申请人： Felix Trampler ,  Ewald Benes ,  Wolfgang Burger ,  Martin Groschl

发明人： Felix Trampler ,  Ewald Benes ,  Wolfgang Burger ,  Martin Groschl

IPC分类号： B01D21/00 ,  B01D43/00 ,  B01J19/10 ,  C02F1/36

CPC分类号： B01D21/283 ,  B01D43/00 ,  B01J19/10

摘要： Particulate material suspended in a fluid is separated and recycled by means of an ultrasonic resonance wave. In a preferred embodiment, the ultrasonic resonance field is generated within a multilayered composite resonator system including a transducer, the suspension and a mirror parallel to each other. Dimensions and frequencies resonant to the whole system but not exciting Eigen-frequencies of transducer and mirror itself are chosen so that thermal dissipation is minimized. Generally, the process is suitable for all kinds of particles (solid, liquid or gaseous disperse phases) especially for hydrosols (particles in water) and for separation of biological particles such as mammalian, bacterial and plant cells or aggregates. Specialized applications in biotechnology are described including an acoustic filter for mammalian cell bioreactors or the selective retention of viable cells relative to nonviable cells.

摘要翻译： 悬浮在流体中的颗粒物质通过超声共振波被分离和循环。 在优选实施例中，在包括换能器，悬架和彼此平行的反射镜的多层复合谐振器系统内产生超声共振场。 尺寸和频率与整个系统共振但不激励选择换能器和反射镜本征频率，以使散热最小化。 通常，该方法适用于各种颗粒（固体，液体或气体分散相），特别是用于水溶胶（水中的颗粒）和分离生物颗粒如哺乳动物，细菌和植物细胞或聚集体。 描述了生物技术中的专门应用，其包括用于哺乳动物细胞生物反应器的声学过滤器或相对于不可维持的细胞选择性保留活细胞。

公开(公告)号：US5626767A

公开(公告)日：1997-05-06

申请号：US88547

申请日：1993-07-02

申请人： Felix Trampler ,  James M. Piret ,  Stefan A. Sonderhoff ,  Douglas G. Kilburn

发明人： Felix Trampler ,  James M. Piret ,  Stefan A. Sonderhoff ,  Douglas G. Kilburn

IPC分类号： B01D21/00 ,  B01D43/00 ,  B01J19/10 ,  G10K11/04 ,  C02F1/36

CPC分类号： B01D21/283 ,  B01D43/00 ,  B01J19/10 ,  G10K11/04

摘要： Particulate material suspended in a fluid is separated and recycled by means of an ultrasonic resonance wave. In a preferred embodiment, the ultrasonic resonance field is generated within a multilayered composite resonator system including a transducer, the suspension and a mirror parallel to each other. Dimensions and frequencies resonant to the whole system but not exciting Eigen-frequencies of transducer and mirror itself are chosen so that thermal dissipation is minimized. Criteria for flow direction and flow rate are defined in order to maintain a high-quality factor of the composite resonator and to achieve a high-separation efficiency. Generally, the process is suitable for all kinds of particles (solid, liquid or gaseous disperse phases) especially for hydrosols (particles in water) and for separation of biological particles such as mammalian, bacterial and plant cells or aggregates. Specialized applications in biotechnology are described including an acoustic filter for mammalian cell bioreactors or the selective retention of viable cells relative to non-viable cells.

摘要翻译： 悬浮在流体中的颗粒物质通过超声共振波被分离和循环。 在优选实施例中，在包括换能器，悬架和彼此平行的反射镜的多层复合谐振器系统内产生超声共振场。 尺寸和频率与整个系统共振但不激励选择换能器和反射镜本征频率，以使散热最小化。 定义了流动方向和流速的标准，以保持复合谐振器的高品质因子并实现高分离效率。 通常，该方法适用于各种颗粒（固体，液体或气体分散相），特别是用于水溶胶（水中的颗粒）和分离生物颗粒如哺乳动物，细菌和植物细胞或聚集体。 描述了生物技术中的专门应用，包括用于哺乳动物细胞生物反应器的声学过滤器或相对于非活细胞选择性保留活细胞。