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公开(公告)号:US5755730A
公开(公告)日:1998-05-26
申请号:US714103
申请日:1996-11-29
申请人: Paul Swain , Feng Gong , Timothy N. Mills
发明人: Paul Swain , Feng Gong , Timothy N. Mills
CPC分类号: A61B17/0469 , A61B17/0467
摘要: A device is provided for cutting threads, particularly curing surgery carried out using an endoscope. The device has a cutting member having at least one aperture extending therethrough of a size sufficient to permit the surgical thread to slide therethrough, the aperture having a thread-cutting edge. In use, the cutting member is located at the distal end of an endoscope.
摘要翻译: PCT No.PCT / GB95 / 00653 Sec。 371日期1996年11月29日第 102(e)日期1996年11月29日PCT 1995年3月23日PCT PCT。 公开号WO95 / 25470 日期1995年9月28日提供一种用于切割螺纹的装置,特别是使用内窥镜进行的固化手术。 该装置具有切割构件,该切割构件具有延伸穿过其中的至少一个孔,其尺寸足以允许外科用螺纹从其中滑动,该孔具有切线边缘。 在使用中,切割构件位于内窥镜的远端。
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公开(公告)号:US5584861A
公开(公告)日:1996-12-17
申请号:US397156
申请日:1995-04-04
申请人: Paul Swain , Feng Gong , Geoffrey J. Brown , Timothy N. Mills
发明人: Paul Swain , Feng Gong , Geoffrey J. Brown , Timothy N. Mills
CPC分类号: A61B17/0487 , A61B17/0469 , A61B2017/045 , A61B2017/0488 , Y10S227/902
摘要: A device for use in securing a thread includes a tube having a distal end and a proximal end. The tube defines a recess at the distal end to receive therein a sleeve having a cavity in which a plug is removably inserted. The device further includes a generally U-shaped stirrup that is movably connected to the tube. The U-shaped stirrup is movable between a first position in which the base of the U holds the sleeve and plug in the recess and a second position in which the sleeve and plug are free to leave the recess. The base of the U is continuous.
摘要翻译: PCT No.PCT / GB93 / 01860 Sec。 371日期:1995年4月4日 102(e)1995年4月4日PCT PCT 1993年9月3日PCT公布。 公开号WO93 / 08747 日期1993年5月13日用于固定螺纹的装置包括具有远端和近端的管。 管在远端限定凹部以容纳其中具有空腔的套筒,其中可拆卸地插入插头。 该装置还包括可移动地连接到管的大致U形的箍筋。 U形箍筋可以在第一位置和第二位置之间移动,在第一位置,U形基座保持套筒并插入凹槽中,第二位置可以使套筒和插头自由离开凹槽。 U的底部是连续的。
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公开(公告)号:US20180291377A1
公开(公告)日:2018-10-11
申请号:US15950392
申请日:2018-04-11
申请人: Jianghui Hou , Yong-feng Gong
发明人: Jianghui Hou , Yong-feng Gong
IPC分类号: C12N15/113 , A61K31/713 , A61K31/495 , A61K31/704
摘要: Among the various aspects of the present disclosure is the provision of a blood brain barrier (BBB) opening agent and uses thereof. An aspect of the present disclosure provides for methods of opening up the BBB; increasing the permeability of the tricellular junction; and using a BBB opening agent for the treatment of a brain pathology or neurological disease, disorder, or condition.
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公开(公告)号:US11021712B1
公开(公告)日:2021-06-01
申请号:US16561602
申请日:2019-09-05
申请人: Jianghui Hou , Yong-feng Gong
发明人: Jianghui Hou , Yong-feng Gong
IPC分类号: A61K48/00 , C07H21/04 , C12N15/113 , A61P3/10
摘要: Among the various aspects of the present disclosure is the provision of miRNA mimics and uses thereof. An aspect of the present disclosure provides for compositions of miRNA mimic molecules and methods of treating metabolic disorders using miRNA mimic molecules.
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公开(公告)号:US06358259B1
公开(公告)日:2002-03-19
申请号:US09428782
申请日:1999-10-28
申请人: Paul Swain , Feng Gong , Geoffrey John Brown , Timothy Noel Mills
发明人: Paul Swain , Feng Gong , Geoffrey John Brown , Timothy Noel Mills
IPC分类号: A61B1704
CPC分类号: A61B1/00089 , A61B17/0469 , A61B17/0482 , A61B17/12013 , A61B2017/00296 , A61B2017/0474 , A61B2017/0475
摘要: A thread guide device is provided which is adapted to be removably or fixedly mounted on the distal end of an endoscope, or which is an integral part thereof. Alternatively, the device may comprise a head joined to the distal end of an elongate example in the form of longitudinally extending passages, which are laterally spaced from one another. The device permits a knot formed by threads which have passed through the thread guides to be viewed by the endoscope.
摘要翻译: 提供了一种线引导装置,其适于可拆卸地或固定地安装在内窥镜的远端上,或者其是其一部分。 或者,装置可以包括以纵向延伸的通道的形式连接到细长实例的远端的头部,其彼此横向间隔开。 该装置允许由穿过导线器的螺纹形成的结被内窥镜观察。
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公开(公告)号:US6010515A
公开(公告)日:2000-01-04
申请号:US806435
申请日:1997-02-26
申请人: Paul Swain , Feng Gong , Geoffrey John Brown , Timothy Noel Mills
发明人: Paul Swain , Feng Gong , Geoffrey John Brown , Timothy Noel Mills
CPC分类号: A61B1/00089 , A61B17/0469 , A61B17/0482 , A61B17/12013 , A61B2017/00296 , A61B2017/0474 , A61B2017/0475
摘要: A thread guide device is provided which is adapted to be removably or fixedly mounted on the distal end of an endoscope, or which is an integral part thereof. Alternatively, the device may comprise a head joined to the distal end of an elongate shaft that is slidable within the endoscope. The device has a pair of thread guides, for example in the form of longitudinally extending passages, which are laterally spaced from one another. The device permits a knot formed by threads which have passed through the thread guides to be viewed by the endoscope.
摘要翻译: 提供了一种线引导装置,其适于可拆卸地或固定地安装在内窥镜的远端上,或者其是其一部分。 或者,该装置可以包括连接到可在内窥镜内滑动的细长轴的远端的头部。 该装置具有一对导线器,例如以纵向延伸的通道的形式,它们彼此横向间隔开。 该装置允许由穿过导线器的螺纹形成的结被内窥镜观察。
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公开(公告)号:US5910105A
公开(公告)日:1999-06-08
申请号:US843229
申请日:1997-04-14
申请人: Paul Swain , Jeffrey Kapec , Kazuna Tanaka , Feng Gong , Geoffrey John Brown , Gerry Ouellette , William M. Tennant, Jr.
发明人: Paul Swain , Jeffrey Kapec , Kazuna Tanaka , Feng Gong , Geoffrey John Brown , Gerry Ouellette , William M. Tennant, Jr.
CPC分类号: A61B17/0469 , A61B1/00128 , A61B1/018 , A61B17/062 , A61B2017/0046 , A61B2017/00469 , A61B2017/061 , A61B2017/306
摘要: A handle is provided for attachment to a medical endoscope for advancing instrumentalities through the instrument channel of the endoscope. The handle is adapted for use with instrumentalities requiring multiple longitudinal strokes to be performed in a predetermined sequence. A detent mechanism is provided to assure that a first stroke is completed before the next succeeding stroke begins. The invention as disclosed is used to operate an endoscopic sewing machine.
摘要翻译: 提供手柄以附接到医用内窥镜,用于通过内窥镜的仪器通道前进器械。 手柄适用于需要以预定顺序执行多个纵向冲程的手段。 提供止动机构以确保在下一个后续行程开始之前完成第一冲程。 所公开的发明用于操作内窥镜缝纫机。
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公开(公告)号:US5792153A
公开(公告)日:1998-08-11
申请号:US718448
申请日:1996-12-16
申请人: Paul Swain , Feng Gong , Geoffrey John Brown , Timothy N Mills
发明人: Paul Swain , Feng Gong , Geoffrey John Brown , Timothy N Mills
CPC分类号: A61B17/0469 , A61B2017/061 , A61B2017/306
摘要: A sewing device is provided for passing a thread through a substrate portion, particularly a portion of a patient's tissue. The device comprises a hollow needle movable between a first position in which it is out of the substrate portion and a second position in which it passes through the substrate portion. A thread carrier is attached to the thread and can be moved from a position being within the hollow needle to a position outside it.
摘要翻译: PCT No.PCT / GB95 / 00652 Sec。 371日期1996年12月16日第 102(e)日期1996年12月16日PCT 1995年3月23日PCT PCT。 WO95 / 25468 PCT出版物 日期1995年9月28日提供了一种缝合装置,用于使线穿过衬底部分,特别是患者组织的一部分。 该装置包括可在其离开基板部分的第一位置和第二位置之间移动的空心针,在第二位置,该中空针穿过基板部分。 螺纹承载件附接到螺纹并且可以从位于空心针内的位置移动到其外部的位置。
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