公开(公告)号：US07183401B1

公开(公告)日：2007-02-27

申请号：US10166325

申请日：1998-03-20

申请人： Yinhua Yu ,  Fengji Xu ,  Robert C. Bast, Jr.

发明人： Yinhua Yu ,  Fengji Xu ,  Robert C. Bast, Jr.

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N5/00

CPC分类号： C07K14/4703 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/021

摘要： Disclosed are compositions and methods comprising a novel tumor suppressor gene, designated NOEY2, that is expressed in normal ovarian and breast surface epithelial cells but consistently absent or down-regulated in ovarian and breast cancer cells. Disclosed are polynucleotide compositions comprising a NOEY2 gene from mammalian sources, and polypeptides encoded by these nucleic acid sequences. Also disclosed are methods for preparing NOEY2 polypeptides, transformed host cells, and antibodies reactive with NOEY2 polypeptides. In certain embodiments, the invention describes methods for diagnosing and treating cancers, as well as methods for identifying NOEY2-related polynucleotide and polypeptide compositions.

摘要翻译： 公开了包括在正常卵巢和乳腺表面上皮细胞中表达但在卵巢和乳腺癌细胞中一贯缺失或下调的称为NOEY2的新型肿瘤抑制基因的组合物和方法。 公开了包含来自哺乳动物来源的NOEY2基因的多核苷酸组合物和由这些核酸序列编码的多肽。 还公开了制备NOEY2多肽，转化的宿主细胞和与NOEY2多肽反应的抗体的方法。 在某些实施方案中，本发明描述了用于诊断和治疗癌症的方法，以及用于鉴定NOEY2相关多核苷酸和多肽组合物的方法。