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公开(公告)号:US20110158906A1
公开(公告)日:2011-06-30
申请号:US12673472
申请日:2008-08-13
IPC分类号: A61K51/06 , C07H21/00 , C07K14/79 , C07K16/32 , C07K14/465 , C12N9/96 , C07K14/705 , C07K16/00 , A61K49/00 , A61K39/395 , A61K31/704 , A61K33/24 , A61K31/337 , A61K31/519 , A61K31/53 , A61K31/192 , C12N5/09 , A61P35/00 , A61P25/00 , A61P1/00 , A61P9/00 , A61P11/00
CPC分类号: A61K47/6921 , A61K47/549 , A61K47/551 , A61K47/60 , A61K47/6907
摘要: The present invention provides a micelle comprising an amphiphilic block copolymer, said amphiphilic block copolymer consisting of (a) a hydrophobic polymer attached to the 5′ end of a first nucleic acid molecule, wherein said first nucleic acid molecule is hybridized with a second nucleic acid molecule, wherein a targeting unit capable of selectively binding to a specific cell type and/or tissue is attached to the 5′ end of said second nucleic acid molecule; and/or (b) a hydrophobic polymer attached to the 3′ end of a first nucleic acid molecule, wherein said first nucleic acid molecule is hybridized with a second nucleic acid molecule, wherein a targeting unit capable of selectively binding to a specific cell type and/or tissue is attached to the 3′ end of said second nucleic acid molecule.
摘要翻译: 本发明提供一种包含两亲性嵌段共聚物的胶束,所述两亲性嵌段共聚物由(a)连接于第一核酸分子的5'端的疏水性聚合物组成,其中所述第一核酸分子与第二核酸 分子,其中能够选择性结合特定细胞类型和/或组织的靶向单元连接到所述第二核酸分子的5'末端; 和/或(b)连接到第一核酸分子的3'末端的疏水性聚合物,其中所述第一核酸分子与第二核酸分子杂交,其中能够选择性结合特定细胞类型的靶向单元 和/或组织连接到所述第二核酸分子的3'末端。