公开(公告)号：US4113863A

公开(公告)日：1978-09-12

申请号：US739142

申请日：1976-11-05

申请人： Manfred Baumgarth ,  Hans-Eckart Radunz ,  Dieter Orth ,  Reinhard Lissner ,  Hans-Joachim Enenkel ,  Filippus Johannes Zeelen

发明人： Manfred Baumgarth ,  Hans-Eckart Radunz ,  Dieter Orth ,  Reinhard Lissner ,  Hans-Joachim Enenkel ,  Filippus Johannes Zeelen

IPC分类号： C07C405/00 ,  C07C177/00 ,  A61K31/19 ,  A61K31/215

CPC分类号： C07C405/00 ,  Y10S514/926 ,  Y10S514/927

摘要： Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl of 1-4 carbon atoms;R.sup.2 is alkyl of 5 - 9 carbon atoms, phenoxymethyl or phenoxymethyl substituted by up to 3 of F, Cl, Br, CH.sub.3, CF.sub.3, or OCH.sub.3 ;R.sup.3 is H or alkyl of 1 - 5 carbon atoms, and physiologically acceptable salts thereof, as well as intermediates therefore are blood-pressure lowering, vasodilatory, diuretic, and nasal mucosa decongesting agents and are produced from intermediates of the formula ##STR2## wherein R.sup.4 is H or acyl of up to 5 carbon atoms and A is CH.sub.2 D or CH.dbd.C(OR.sup.5); D is carbonyl or dialkoxypolymethylene of up to 7 carbon atoms.

公开(公告)号：US4086362A

公开(公告)日：1978-04-25

申请号：US634349

申请日：1975-11-24

申请人： Manfred Baumgarth ,  Hans-Eckart Radunz ,  Dieter Orth ,  Reinhard Lissner ,  Hans-Joachim Enenkel ,  Filippus Johannes Zeelen

发明人： Manfred Baumgarth ,  Hans-Eckart Radunz ,  Dieter Orth ,  Reinhard Lissner ,  Hans-Joachim Enenkel ,  Filippus Johannes Zeelen

IPC分类号： A61K31/20 ,  A61K31/215 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07C177/00 ,  A61K31/19

CPC分类号： C07C405/00

摘要： Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl or 1-4 carbon atoms;R.sup.2 is alkyl of 5 - 9 carbon atoms, phenoxymethyl or phenoxymethyl substituted by up to 3 of F, Cl, Br, CH.sub.3, CF.sub.3, or OCH.sub.3 ;R.sup.3 is H or alkyl or 1 - 5 carbon atoms, and physiologically acceptable salts thereof, as well as intermediates therefore are blood-pressure lowering, vasodilatory, diuretic and nasal mucosa decongesting agents.

摘要翻译： 其中R1为H或烷基或1-4个碳原子的通式为“IMAGE”的前荆芥酸衍生物; R 2是5-9个碳原子的烷基，被至多3个F，Cl，Br，CH 3，CF 3或OCH 3取代的苯氧基甲基或苯氧基甲基; R3是H或烷基或1-5个碳原子，其生理上可接受的盐，以及中间体因此是降血压，血管扩张，利尿和鼻粘膜减充血剂。