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公开(公告)号:US07943588B2
公开(公告)日:2011-05-17
申请号:US11691783
申请日:2007-03-27
申请人: Joyce A. DeLeo , Flobert Y. Tanga
发明人: Joyce A. DeLeo , Flobert Y. Tanga
IPC分类号: A61K48/00 , A61K39/395 , A61K45/00 , C07H21/04 , C07K16/00
CPC分类号: C07K14/705 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , C12N15/1138 , C12N15/8509 , C12N2310/11 , C12N2310/14
摘要: The present invention is a method for preventing or treating neuropathic pain. Using an agent to decrease the expression or activity of Toll-like receptor 4 (TLR4), behavioral hypersensitivity is attenuated thereby preventing or treating neuropathic pain in a subject in need of such treatment.
摘要翻译: 本发明是一种预防或治疗神经性疼痛的方法。 使用药物降低Toll样受体4(TLR4)的表达或活性,行为超敏反应减弱,从而预防或治疗需要这种治疗的受试者的神经性疼痛。