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公开(公告)号:US09707304B2
公开(公告)日:2017-07-18
申请号:US14970459
申请日:2015-12-15
IPC分类号: A61K48/00 , C12N15/86 , C12N5/0793 , C12N5/079 , C12N15/63 , A61K38/39 , A61K9/00 , C07K14/78 , C12N7/00
CPC分类号: A61K48/0066 , A61K9/0048 , A61K38/39 , A61K48/005 , A61K48/0058 , C07K14/78 , C12N5/062 , C12N5/0621 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2710/10041 , C12N2710/10071 , C12N2750/14121 , C12N2750/14143 , C12N2750/14171 , C12N2830/002 , C12N2830/008 , C12N2830/32
摘要: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.
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公开(公告)号:US20220260663A1
公开(公告)日:2022-08-18
申请号:US17622584
申请日:2020-08-28
摘要: A practically implementable robust direction-of-arrival (DoA) estimation approach that is resistant to localization errors due to mobility, multipath reflections, impulsive noise, and multiple-access interference. As part of the disclosed invention the inventors consider infrastructure-less 3D localization of autonomous underwater vehicles (AUVs) with no GPS assistance and no availability of global clock synchronization. The proposed method can be extended to challenging communication environments and applied for the localization of assets/objects in space, underground, intrabody, underwater and other complex, challenging, congested and sometimes contested environments. Each AUV leverages known-location beacon signals to self-localize and can simultaneously report its sensor data and measurement location. The approach uses two known location beacon nodes, where the beacons are single-hydrophone acoustic nodes that are deployed at known locations and transmit time-domain coded signals in a spread-spectrum fashion.
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公开(公告)号:US20160144056A1
公开(公告)日:2016-05-26
申请号:US14970459
申请日:2015-12-15
CPC分类号: A61K48/0066 , A61K9/0048 , A61K38/39 , A61K48/005 , A61K48/0058 , C07K14/78 , C12N5/062 , C12N5/0621 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2710/10041 , C12N2710/10071 , C12N2750/14121 , C12N2750/14143 , C12N2750/14171 , C12N2830/002 , C12N2830/008 , C12N2830/32
摘要: The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.
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