公开(公告)号：US20140349275A1

公开(公告)日：2014-11-27

申请号：US14264462

申请日：2014-04-29

Applicant: Focus Diagnostics, Inc.

Inventor： Fan Chen ,  Lilly I. Kong ,  Jules Chen ,  Mehrdad Jannatipour

IPC: C12Q1/70

CPC classification number: C12Q1/701 ,  C12N2710/22011 ,  C12Q2600/158

Abstract: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.

Abstract translation: 本发明提供用于样品中BK病毒的快速，灵敏和高度特异性核酸（例如基于DNA）检测的方法和组合物。 通常，所述方法涉及检测具有BK病毒基因组的保守区的靶序列的靶核酸。 本发明还包括用于本发明方法的组合物，包括引物，探针和试剂盒。

公开(公告)号：US09745638B2

公开(公告)日：2017-08-29

申请号：US14264462

申请日：2014-04-29

Applicant: Focus Diagnostics, Inc.

Inventor： Fan Chen ,  Lilly I. Kong ,  Jules Chen ,  Mehrdad Jannatipour

IPC: C12P19/34 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/70

CPC classification number: C12Q1/701 ,  C12N2710/22011 ,  C12Q2600/158

Abstract: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.

公开(公告)号：US20160040213A1

公开(公告)日：2016-02-11

申请号：US14881506

申请日：2015-10-13

Applicant: 3M Innovative Properties Company ,  Focus Diagnostics, Inc.

Inventor： Peter D. Ludowise ,  David A. Whitman ,  Kyle C. Armantrout ,  Maurice Exner ,  Lucien A.E. Jacky ,  Michelle Tabb

IPC: C12Q1/68 ,  G01N35/04 ,  G01N21/64 ,  G01N35/02

CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/6486 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0441

Abstract: Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material.

Abstract translation: 用于处理样品处理装置的系统和方法。 该系统可以包括样品处理装置，该样品处理装置包括检测室，被配置为围绕旋转轴线旋转样品处理装置的马达和相对于样品处理装置可操作地定位的光学模块，并配置成确定所选择的材料体积 存在于样品处理装置的检测室中。 该方法可以包括围绕旋转轴旋转样品处理装置，并且在旋转样品处理装置的同时确定所选择的材料体积是否存在于检测室中。 在一些实施例中，确定所选择的材料体积是否存在可以通过光学询问该检测室以获得该材料的光学特性。