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公开(公告)号：US09533041B2
公开(公告)日：2017-01-03
申请号：US13991182
申请日：2011-12-05
申请人： Frédéric Jaisser
发明人： Frédéric Jaisser
IPC分类号： A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/115 , A61K39/395 , A61K31/7088
CPC分类号： C12N15/1135 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K39/3955 , C07K16/32 , C07K2317/76 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/16 , C12N2320/30
摘要： The present invention relates to an inhibitor of NGAL gene expression or a NGAL antagonist for use in the prevention or the treatment of heart failure.
摘要翻译： 本发明涉及用于预防或治疗心力衰竭的NGAL基因表达抑制剂或NGAL拮抗剂。
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2.发明申请公开(公告)号：US20170002358A1
公开(公告)日：2017-01-05
申请号：US15250007
申请日：2016-08-29
申请人： Frédéric JAISSER , Nicolette FARMAN
发明人： Frédéric JAISSER , Nicolette FARMAN
IPC分类号： C12N15/113 , C12N15/115 , C07K16/32
CPC分类号： C12N15/1135 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K39/3955 , C07K16/32 , C07K2317/76 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/16 , C12N2320/30
摘要： The present invention relates to an inhibitor of NGAL gene expression or a NGAL antagonist for use in the prevention or the treatment of heart failure.
摘要翻译： 本发明涉及用于预防或治疗心力衰竭的NGAL基因表达抑制剂或NGAL拮抗剂。
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3.发明申请公开(公告)号：US20130315932A1
公开(公告)日：2013-11-28
申请号：US13991182
申请日：2011-12-05
申请人： Frédéric Jaisser
发明人： Frédéric Jaisser
IPC分类号： A61K39/395 , A61K31/7088 , A61K31/713
CPC分类号： C12N15/1135 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K39/3955 , C07K16/32 , C07K2317/76 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/16 , C12N2320/30
摘要： The present invention relates to an inhibitor of NGAL gene expression or a NGAL antagonist for use in the prevention or the treatment of heart failure.
摘要翻译： 本发明涉及用于预防或治疗心力衰竭的NGAL基因表达抑制剂或NGAL拮抗剂。
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公开(公告)号：US07067648B2
公开(公告)日：2006-06-27
申请号：US09877935
申请日：2001-06-08
申请人： Daniel Pinto , Sylvie Robine , Frédéric Jaisser , Daniel Louvard
发明人： Daniel Pinto , Sylvie Robine , Frédéric Jaisser , Daniel Louvard
IPC分类号： C07H21/04
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , C07K14/4735 , C12N15/8509 , C12N2830/00 , C12N2830/008 , C12N2830/85 , C12N2840/44
摘要： The invention relates to regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of the intestine and uro-genital tracts. The invention also relates to recombinant constructs comprising said regulatory sequences, for the control of the targeted expression of determined nucleic acid sequences so-called (heterologous sequences or also transgenes), in cells or tissues originating from the intestinal mucosa. A further object of the invention is to provide cells, tissues or organisms including animals, expressing said determined nucleic acid sequences in a targeted manner.
摘要翻译： 本发明涉及有效驱动肠和泌尿生殖道未成熟和分化的上皮细胞中的转基因表达的小鼠绒毛蛋白基因的调控序列。 本发明还涉及包含所述调节序列的重组构建体，用于在源于肠粘膜的细胞或组织中控制所谓的（异源序列或转基因）的确定的核酸序列的靶向表达。 本发明的另一个目的是提供以目标方式表达所述确定的核酸序列的包括动物的细胞，组织或生物。
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公开(公告)号：US10059946B2
公开(公告)日：2018-08-28
申请号：US15250007
申请日：2016-08-29
申请人： Frédéric Jaisser , Nicolette Farman
发明人： Frédéric Jaisser , Nicolette Farman
IPC分类号： A61K39/395 , C07K16/32 , C12N15/113 , A61K31/7105 , A61K31/713 , C12N15/115 , A61K31/7088
CPC分类号： C12N15/1135 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K39/3955 , C07K16/32 , C07K2317/76 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/16 , C12N2320/30
摘要： The present invention relates to an inhibitor of NGAL gene expression or a NGAL antagonist for use in the prevention or the treatment of heart failure.
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6.发明授权Methods and compositions for stimulating reepithelialisation during wound healing 有权用于刺激伤口愈合期间上皮再生的方法和组合物公开(公告)号：US09241944B2
公开(公告)日：2016-01-26
申请号：US13703923
申请日：2011-06-16
IPC分类号： A61K31/585 , A61K31/56 , A61K31/44 , A61K31/575 , A61K9/00 , A61K9/70 , A61K31/00
CPC分类号： A61K31/585 , A61K9/0014 , A61K9/0048 , A61K9/7023 , A61K31/00 , A61K31/575 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The present invention relates to methods and compositions for stimulating reepithelialization during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialization of the skin or of the cornea during wound healing.
摘要翻译： 本发明涉及用于在伤口愈合过程中刺激再上皮细胞化的方法和组合物。 更具体地说，本发明涉及一种用于在伤口愈合过程中刺激皮肤或角膜上皮再生的方法中的盐皮质激素受体基因表达的抑制剂。
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7.发明申请公开(公告)号：US20130143850A1
公开(公告)日：2013-06-06
申请号：US13703923
申请日：2011-06-16
IPC分类号： A61K31/575 , A61K31/585
CPC分类号： A61K31/585 , A61K9/0014 , A61K9/0048 , A61K9/7023 , A61K31/00 , A61K31/575 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The present invention relates to methods and compositions for stimulating reepithelialisation during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialisation of the skin or of the cornea during wound healing.
摘要翻译： 本发明涉及用于在伤口愈合期间刺激上皮再生的方法和组合物。 更具体地说，本发明涉及一种用于在伤口愈合过程中刺激皮肤或角膜上皮再生的方法中的盐皮质激素受体基因表达的抑制剂。
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