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公开(公告)号：US10059946B2
公开(公告)日：2018-08-28
申请号：US15250007
申请日：2016-08-29
申请人： Frédéric Jaisser , Nicolette Farman
发明人： Frédéric Jaisser , Nicolette Farman
IPC分类号： A61K39/395 , C07K16/32 , C12N15/113 , A61K31/7105 , A61K31/713 , C12N15/115 , A61K31/7088
CPC分类号： C12N15/1135 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K39/3955 , C07K16/32 , C07K2317/76 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/16 , C12N2320/30
摘要： The present invention relates to an inhibitor of NGAL gene expression or a NGAL antagonist for use in the prevention or the treatment of heart failure.
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2.发明授权Methods and compositions for stimulating reepithelialisation during wound healing 有权用于刺激伤口愈合期间上皮再生的方法和组合物公开(公告)号：US09241944B2
公开(公告)日：2016-01-26
申请号：US13703923
申请日：2011-06-16
IPC分类号： A61K31/585 , A61K31/56 , A61K31/44 , A61K31/575 , A61K9/00 , A61K9/70 , A61K31/00
CPC分类号： A61K31/585 , A61K9/0014 , A61K9/0048 , A61K9/7023 , A61K31/00 , A61K31/575 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The present invention relates to methods and compositions for stimulating reepithelialization during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialization of the skin or of the cornea during wound healing.
摘要翻译： 本发明涉及用于在伤口愈合过程中刺激再上皮细胞化的方法和组合物。 更具体地说，本发明涉及一种用于在伤口愈合过程中刺激皮肤或角膜上皮再生的方法中的盐皮质激素受体基因表达的抑制剂。
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3.发明申请公开(公告)号：US20130143850A1
公开(公告)日：2013-06-06
申请号：US13703923
申请日：2011-06-16
IPC分类号： A61K31/575 , A61K31/585
CPC分类号： A61K31/585 , A61K9/0014 , A61K9/0048 , A61K9/7023 , A61K31/00 , A61K31/575 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The present invention relates to methods and compositions for stimulating reepithelialisation during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialisation of the skin or of the cornea during wound healing.
摘要翻译： 本发明涉及用于在伤口愈合期间刺激上皮再生的方法和组合物。 更具体地说，本发明涉及一种用于在伤口愈合过程中刺激皮肤或角膜上皮再生的方法中的盐皮质激素受体基因表达的抑制剂。
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公开(公告)号：US09682089B2
公开(公告)日：2017-06-20
申请号：US14959015
申请日：2015-12-04
IPC分类号： A61K31/585 , A61K9/00 , A61K9/70 , A61K31/00 , A61K31/575 , C12N15/113
CPC分类号： A61K31/585 , A61K9/0014 , A61K9/0048 , A61K9/7023 , A61K31/00 , A61K31/575 , C12N15/1138 , C12N2310/11 , C12N2310/12 , C12N2310/14
摘要： The present invention relates to methods and compositions for stimulating reepithelialization during wound healing. More particularly, the present invention relates to a mineralocorticoid receptor antagonist or an inhibitor of mineralocorticoid receptor gene expression for use in a method for stimulating reepithelialization of the skin or of the cornea during wound healing.
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公开(公告)号：US20110257140A1
公开(公告)日：2011-10-20
申请号：US13124575
申请日：2009-10-21
IPC分类号： A61K31/585 , G01N33/566 , A61P3/00 , A61P9/00 , A61P3/10 , A61P3/04 , C12Q1/68 , A61K31/5685
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N2800/04 , G01N2800/042 , G01N2800/044 , G01N2800/32 , G01N2800/321 , G01N2800/325 , G01N2800/52
摘要： The present invention relates to the use of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and/or SERPINA3 as biomarkers of the Mineralocorticoid Receptor (MR) activation in a patient. More particularly, the present invention relates to a method for predicting the responsiveness of a patient to a treatment with a MR antagonist or an aldosterone synthase inhibitor, said method comprising determining in a biological sample obtained from said patient the expression level of the NGAL gene and/or of the SERPINA3 gene.
摘要翻译： 本发明涉及中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和/或SERPINA3作为患者中的盐皮质激素受体（MR）激活的生物标志物的用途。 更具体地，本发明涉及一种用于预测患者对用MR拮抗剂或醛固酮合酶抑制剂治疗的反应性的方法，所述方法包括在从所述患者获得的生物样品中测定NGAL基因的表达水平和 /或SERPINA3基因。
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6.发明授权Methods and compositions for the treatment of fluid accumulation in and/or under the retina 有权用于治疗视网膜内和/或视网膜下的液体积聚的方法和组合物公开(公告)号：US08957052B2
公开(公告)日：2015-02-17
申请号：US13696345
申请日：2011-05-10
IPC分类号： A61K31/573
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/0051
摘要： The present invention provides methods and compositions for the treatment of fluid accumulation in and/or under the retina.
摘要翻译： 本发明提供了用于治疗视网膜内和/或视网膜下的液体积聚的方法和组合物。
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7.发明申请METHODS AND COMPOSITIONS FOR THE TREATMENT OF FLUID ACCUMULATION IN AND/ OR UNDER THE RETINA 有权用于治疗和/或在RETINA下流体积累的方法和组合物公开(公告)号：US20130131024A1
公开(公告)日：2013-05-23
申请号：US13696345
申请日：2011-05-10
IPC分类号： A61K31/573
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/0051
摘要： The present invention provides methods and compositions for the treatment of fluid accumulation in and/or under the retina.
摘要翻译： 本发明提供了用于治疗视网膜内和/或视网膜下的液体积聚的方法和组合物。
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