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公开(公告)号:US20190241627A1
公开(公告)日:2019-08-08
申请号:US16211083
申请日:2018-12-05
发明人: Karl Deisseroth , Ofer Yizhar , Lief Fenno , Peter Hegemann , Matthias Prigge
IPC分类号: C07K14/405 , A61N5/06 , C07K19/00 , C12N13/00 , G01N33/50 , A01K67/027
CPC分类号: C07K14/405 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61N5/06 , A61N2005/0663 , C07K19/00 , C07K2319/00 , C07K2319/60 , C12N13/00 , G01N33/5058 , G01N2500/10
摘要: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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公开(公告)号:US20180360007A1
公开(公告)日:2018-12-20
申请号:US15960642
申请日:2018-04-24
发明人: Andrew J. Murphy
IPC分类号: A01K67/027 , C07K14/54
CPC分类号: A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/07 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A01K2267/0331 , A01K2267/0387 , A01K2267/0393 , C07K14/5418
摘要: Genetically modified non-human animals comprising a human or humanized interleukin-7 (IL-7) gene. Cells, embryos, and non-human animals comprising a human or humanized IL-7 gene. Rodents that express human or humanized IL-7 protein. Genetically modified mice that comprise a human or humanized IL-7-encoding gene in their germline, wherein the human or humanized IL-7-encoding gene is under control of endogenous mouse IL-7 regulatory sequences.
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公开(公告)号:US20180139939A1
公开(公告)日:2018-05-24
申请号:US15870172
申请日:2018-01-12
IPC分类号: A01K67/027 , A61K49/00 , C12N15/85
CPC分类号: A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K49/0008 , C12N15/8509 , C12N2015/859 , C12N2830/008
摘要: This disclosure provides non-human animal models for age-related disorders and age-sensitive traits, particularly those caused by senescence-inducing stimuli, wherein the models comprise transgenes selectively expressed by senescent cells. The disclosure further provides methods for identifying therapeutic agents effective for treating or preventing age-related disorders and age-sensitive traits using the animal models, therapeutic agents identified using such methods, pharmaceutical compositions comprising the identified therapeutic agents, and methods of treating or preventing age-related disorders and age-sensitive traits.
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公开(公告)号:US09968652B2
公开(公告)日:2018-05-15
申请号:US15194379
申请日:2016-06-27
发明人: Karl Deisseroth , Kay Tye , Lief Fenno
IPC分类号: A61K41/00 , A61K38/17 , A01K67/027 , A61K49/00 , A61B5/16 , A61N5/06 , A61K9/00 , A61K48/00 , C07K14/705 , C12N7/00 , C12N15/85 , C12N15/86 , G01N33/50
CPC分类号: A61K38/177 , A01K67/0275 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/0356 , A01K2267/0393 , A61B5/165 , A61K9/0019 , A61K41/00 , A61K48/0058 , A61K49/0004 , A61K49/0008 , A61N5/062 , C07K14/705 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2015/859 , C12N2750/14143 , C12N2799/025 , G01N33/5088
摘要: Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
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公开(公告)号:US20180105835A1
公开(公告)日:2018-04-19
申请号:US15692866
申请日:2017-08-31
申请人: VILNIUS UNIVERSITY
发明人: Thomas FRICKE , Matthias BOCHTLER , Gintautas TAMULAITIS , Migle KAZLAUSKIENE , Virginijus SIKSNYS
IPC分类号: C12N15/85 , C12N9/22 , C12N15/113 , C07K14/315
CPC分类号: C12N15/8509 , A01K2217/058 , A01K2217/07 , A01K2227/40 , A01K2267/0306 , A01K2267/0393 , C07K14/315 , C12N9/22 , C12N15/113 , C12N2310/11 , C12N2310/20 , C12N2310/3233 , C12N2310/3519 , C12N2310/531 , C12N2320/30
摘要: Methods and compositions using a CRISPR-Cas Type IIIA resulting in RNA gene knockdown and knockout in an animal.
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公开(公告)号:US20180064075A1
公开(公告)日:2018-03-08
申请号:US15675003
申请日:2017-08-11
申请人: GLOFISH LLC
IPC分类号: A01K67/027 , C07K14/435 , C12N15/85 , G06Q99/00
CPC分类号: A01K67/0275 , A01K67/027 , A01K2217/05 , A01K2217/052 , A01K2217/206 , A01K2227/40 , A01K2267/0393 , C07K14/43595 , C12N15/8509 , C12N2830/008 , G06Q99/00
摘要: The present invention relates to the method and use of reef coral fluorescent proteins in making transgenic red, green and yellow fluorescent zebrafish. Preferably, such fluorescent zebrafish are fertile and used to establish a population of transgenic zebrafish and to provide to the ornamental fish industry for the purpose of marketing. Thus, new varieties of ornamental fish of different fluorescence colors from a novel source are developed.
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公开(公告)号:US09902971B2
公开(公告)日:2018-02-27
申请号:US14751807
申请日:2015-06-26
发明人: David Frendewey , Gustavo Droguett , Anthony Gagliardi , Junko Kuno , Wojtek Auerbach , David M. Valenzuela
IPC分类号: C12N15/90 , C12N5/0735 , C12N15/85 , A01K67/027
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2217/075 , A01K2227/105 , A01K2267/02 , A01K2267/0393 , C12N5/0606 , C12N15/907 , C12N2500/60 , C12N2517/00
摘要: Methods and compositions are provided for generating targeted genetic modifications on the Y chromosome or a challenging target locus. Compositions include an in vitro culture comprising an XY pluripotent and/or totipotent animal cell (i.e., XY ES cells or XY iPS cells) having a modification that decreases the level and/or activity of an Sry protein; and, culturing these cells in a medium that promotes development of XY F0 fertile females. Such compositions find use in various methods for making a fertile female XY non-human mammal in an F0 generation.
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公开(公告)号:US20180051058A1
公开(公告)日:2018-02-22
申请号:US15803472
申请日:2017-11-03
发明人: Karl Deisseroth , Ofer Yizhar , Lief Fenno , Peter Hegemann , Matthias Prigge
IPC分类号: C07K14/405 , A01K67/027 , C07K19/00 , C12N13/00 , G01N33/50 , A61N5/06 , A61K38/00
CPC分类号: C07K14/405 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61N5/06 , A61N2005/0663 , C07K19/00 , C07K2319/00 , C07K2319/60 , C12N13/00 , G01N33/5058 , G01N2500/10
摘要: Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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公开(公告)号:US09827278B2
公开(公告)日:2017-11-28
申请号:US14876195
申请日:2015-10-06
发明人: David Kirn
IPC分类号: A61K35/768 , C07K14/535 , A01K67/027 , A61K49/00 , A61K9/00 , C12N7/00 , A61K39/00 , C12N15/86 , A61K38/00
CPC分类号: A61K35/768 , A01K67/0271 , A01K2207/20 , A01K2227/105 , A01K2267/0331 , A01K2267/0393 , A61K9/0019 , A61K38/00 , A61K49/0008 , A61K2039/54 , C07K14/535 , C12N7/00 , C12N15/86 , C12N2710/24111 , C12N2710/24132 , C12N2710/24143 , A61K2300/00
摘要: The present invention concerns methods and compositions for the treatment of cancer and cancer cells using intravascular administration of a vaccinia virus. In some embodiments, methods and compositions involve a replicative vaccinia virus that encodes GM-CSF.
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公开(公告)号:US09777276B2
公开(公告)日:2017-10-03
申请号:US14479006
申请日:2014-09-05
申请人: Institut Pasteur
发明人: Lucie Peduto , Gerard Eberl
IPC分类号: A61K39/395 , A61K39/00 , C12N15/113 , A61K38/48 , G01N33/573 , G01N33/68 , A01K67/027 , C12Q1/68 , C12N15/85
CPC分类号: C12N15/1137 , A01K67/0275 , A01K2217/203 , A01K2217/206 , A01K2227/105 , A01K2267/0368 , A01K2267/0393 , A61K38/4886 , C12N15/8509 , C12N2015/859 , C12N2310/14 , C12N2320/30 , C12N2800/107 , C12N2820/55 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , C12Y304/24 , G01N33/573 , G01N33/6893 , G01N2333/96486 , G01N2500/00 , G01N2800/085 , G01N2800/12 , G01N2800/382
摘要: The present invention relates to the field of fibrosis and inflammation and more particularly to the use of ADAM12 (A Disintegrin and Metalloproteinase 12) inhibitors to prevent or treat inflammation-induced fibrosis. The present invention also relates to the use of ADAM12 as a marker for inflammation-induced fibrosis and to the ablation of ADAM12 expressing cells as therapeutic approach to interfere with the development of pro-fibrotic cells.
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