公开(公告)号：US09993432B2

公开(公告)日：2018-06-12

申请号：US13130294

申请日：2009-11-19

申请人： Alexander Kuhl ,  Erich Brendel ,  Frank Bröcker ,  Adrian Funke ,  Andreas Ohm ,  Dennis Kvesic ,  Thomas Volkmer

发明人： Alexander Kuhl ,  Erich Brendel ,  Frank Bröcker ,  Adrian Funke ,  Andreas Ohm ,  Dennis Kvesic ,  Thomas Volkmer

IPC分类号： A61K9/20 ,  A61K9/48 ,  A61K9/24 ,  A61K31/4422 ,  A61K9/00 ,  A61K9/28 ,  A61K31/4178 ,  A61K31/4184 ,  A61K45/06

CPC分类号： A61K9/2031 ,  A61K9/0004 ,  A61K9/2072 ,  A61K9/2086 ,  A61K9/209 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4422 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin II antagonist and/or at least one diuretic, characterized in that nifedipine or nisoldipine is released in the body in a controlled (modified) manner and the angiotensin II antagonist and/or the diuretic is released rapidly (immediate release (IR)), and also to processes for their preparation, to their use as medicaments and to their use for the prophylaxis, secondary prophylaxis or treatment of disorders.

公开(公告)号：US20120034272A1

公开(公告)日：2012-02-09

申请号：US13130294

申请日：2009-11-19

申请人： Alexander Kuhl ,  Erich Brendel ,  Frank Bröcker ,  Adrian Funke ,  Andreas Ohm ,  Dennis Kvesic ,  Thomas Volkmer

发明人： Alexander Kuhl ,  Erich Brendel ,  Frank Bröcker ,  Adrian Funke ,  Andreas Ohm ,  Dennis Kvesic ,  Thomas Volkmer

IPC分类号： A61K31/4422 ,  A61K31/635 ,  A61K31/4965 ,  B05D1/02 ,  A61K31/519 ,  A61P7/10 ,  A61P9/12 ,  B05D5/00 ,  A61K9/00 ,  A61K31/585

CPC分类号： A61K9/2031 ,  A61K9/0004 ,  A61K9/2072 ,  A61K9/2086 ,  A61K9/209 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4422 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin II antagonist and/or at least one diuretic, characterized in that nifedipine or nisoldipine is released in the body in a controlled (modified) manner and the angiotensin II antagonist and/or the diuretic is released rapidly (immediate release (IR)), and also to processes for their preparation, to their use as medicaments and to their use for the prophylaxis, secondary prophylaxis or treatment of disorders.

摘要翻译： 本发明涉及包含硝苯地平或尼索地平与至少一种血管紧张素II拮抗剂和/或至少一种利尿剂的活性成分组合的药物剂型，其特征在于硝苯地平或尼索地平在受控（改良） 方式，并且血管紧张素II拮抗剂和/或利尿剂快速释放（即时释放（IR）），以及它们的制备方法，用作药物及其用于预防，二次预防或治疗疾病的用途。