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公开(公告)号：US06294201B1
公开(公告)日：2001-09-25
申请号：US09530158
申请日：2000-04-25
申请人： Stefan Kettelhoit , Ranga-Rao Kanikanti , Erich Brendel , Claus Weisemann , Ernst Chantraine , Michael Eisele , Patrick Bosché
发明人： Stefan Kettelhoit , Ranga-Rao Kanikanti , Erich Brendel , Claus Weisemann , Ernst Chantraine , Michael Eisele , Patrick Bosché
IPC分类号： A61K924
CPC分类号： A61K9/0004
摘要： This invention relates to an orally administered osmotic drug release system that consists of a shell and a core containing a pharmaceutically active substance, as well as a process for its production. The invention relates further to an osmotic drug release system for use as a drug in human beings and animals, as well as the use of the osmotic drug release system in the production of a drug for the treatment and/or prevention of illnesses in human beings and animals.
摘要翻译： 本发明涉及口服给药的渗透药物释放系统，其由壳和含有药物活性物质的核心组成，以及其生产方法。 本发明进一步涉及用作人和动物中的药物的渗透药物释放系统，以及在生产用于治疗和/或预防人类疾病的药物中使用渗透药物释放系统 和动物。
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2.发明授权公开(公告)号：US06805881B1
公开(公告)日：2004-10-19
申请号：US09787229
申请日：2001-04-23
IPC分类号： A61K914
CPC分类号： A61K31/4422 , A61K9/1652
摘要： The present invention relates to orally administrable multiple-unit sustained-release dose forms having controlled agitation-independent release of active compound and processes for their production using a selected erodable hydrophilic polymer (HPC) and a limitation of the maximum size of the active compound-containing polymer particles to ≦3 mm.
摘要翻译： 本发明涉及具有受控搅动独立的活性化合物释放的可口服给药的多单位缓释剂量形式及其使用选择的可侵蚀亲水性聚合物（HPC）的生产方法，以及活性化合物 - 含有聚合物颗粒至<= 3MM。
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公开(公告)号：US09993432B2
公开(公告)日：2018-06-12
申请号：US13130294
申请日：2009-11-19
申请人： Alexander Kuhl , Erich Brendel , Frank Bröcker , Adrian Funke , Andreas Ohm , Dennis Kvesic , Thomas Volkmer
发明人： Alexander Kuhl , Erich Brendel , Frank Bröcker , Adrian Funke , Andreas Ohm , Dennis Kvesic , Thomas Volkmer
IPC分类号： A61K9/20 , A61K9/48 , A61K9/24 , A61K31/4422 , A61K9/00 , A61K9/28 , A61K31/4178 , A61K31/4184 , A61K45/06
CPC分类号： A61K9/2031 , A61K9/0004 , A61K9/2072 , A61K9/2086 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K31/4178 , A61K31/4184 , A61K31/4422 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin II antagonist and/or at least one diuretic, characterized in that nifedipine or nisoldipine is released in the body in a controlled (modified) manner and the angiotensin II antagonist and/or the diuretic is released rapidly (immediate release (IR)), and also to processes for their preparation, to their use as medicaments and to their use for the prophylaxis, secondary prophylaxis or treatment of disorders.
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4.发明申请Pharmaceutical dosage form comprising nifedipine or nisoldipine and an angiotensin II antagonist and/or a diuretic 有权包含硝苯地平或尼索地平和血管紧张素II拮抗剂和/或利尿剂的药物剂型公开(公告)号：US20120034272A1
公开(公告)日：2012-02-09
申请号：US13130294
申请日：2009-11-19
申请人： Alexander Kuhl , Erich Brendel , Frank Bröcker , Adrian Funke , Andreas Ohm , Dennis Kvesic , Thomas Volkmer
发明人： Alexander Kuhl , Erich Brendel , Frank Bröcker , Adrian Funke , Andreas Ohm , Dennis Kvesic , Thomas Volkmer
IPC分类号： A61K31/4422 , A61K31/635 , A61K31/4965 , B05D1/02 , A61K31/519 , A61P7/10 , A61P9/12 , B05D5/00 , A61K9/00 , A61K31/585
CPC分类号： A61K9/2031 , A61K9/0004 , A61K9/2072 , A61K9/2086 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K31/4178 , A61K31/4184 , A61K31/4422 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical dosage form comprising an active ingredient combination of nifedipine or nisoldipine and at least one angiotensin II antagonist and/or at least one diuretic, characterized in that nifedipine or nisoldipine is released in the body in a controlled (modified) manner and the angiotensin II antagonist and/or the diuretic is released rapidly (immediate release (IR)), and also to processes for their preparation, to their use as medicaments and to their use for the prophylaxis, secondary prophylaxis or treatment of disorders.
摘要翻译： 本发明涉及包含硝苯地平或尼索地平与至少一种血管紧张素II拮抗剂和/或至少一种利尿剂的活性成分组合的药物剂型，其特征在于硝苯地平或尼索地平在受控（改良） 方式，并且血管紧张素II拮抗剂和/或利尿剂快速释放（即时释放（IR）），以及它们的制备方法，用作药物及其用于预防，二次预防或治疗疾病的用途。
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