公开(公告)号：US20150157779A1

公开(公告)日：2015-06-11

申请号：US14411665

申请日：2013-06-27

申请人： Fresenius Medicasl Care Deutschland GmbH

发明人： Dieter Falkenhagen ,  Jens Hartmann ,  Stephan Harm

IPC分类号： A61M1/34 ,  A61M1/36

CPC分类号： A61M1/3472 ,  A61K31/745 ,  A61K38/12 ,  A61M1/3486 ,  A61M1/3679 ,  A61M2202/0413 ,  A61M2202/0456 ,  A61M2202/049 ,  A61M2205/3303 ,  A61M2205/75 ,  B01J20/261 ,  B01J20/264 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28019 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/321 ,  B01J20/3214 ,  B01J20/3246 ,  B01J20/3274

摘要： Embodiments of the invention relate to an extracorporeal perfusion apparatus comprising an extracorporeal blood circuit for conveying blood, a filtrate circuit for conveying blood plasma, and a controller, wherein the filtrate circuit is connected to the extracorporeal blood circuit by means of a filter, wherein the filter has a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and wherein a depletion agent comprising a first carrier having a neutral, hydrophobic surface is arranged in the filtrate circuit, wherein the perfusion apparatus comprises a dispensing means for feeding an endotoxin-binding lipopeptide into the extracorporeal blood circuit, wherein the endotoxin-binding lipopeptide is selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof, and a combination thereof.