公开(公告)号：US20240277755A1

公开(公告)日：2024-08-22

申请号：US18444852

申请日：2024-02-19

申请人： Yao-Foli Sekyema

发明人： Yao-Foli Sekyema

IPC分类号： A61K31/745 ,  A61B5/00 ,  A61B5/021 ,  A61K9/00

CPC分类号： A61K31/745 ,  A61B5/021 ,  A61B5/4848 ,  A61K9/0053

摘要： A hypertension preload treatment formulation for limiting ingested sodium from entering the bloodstream and method of using the same. The hypertension preload treatment formulation is provided in an oral dosage from. The hypertension preload treatment formulation comprises a therapeutically effective dosage of a sodium-binding agent and an excipient. The sodium-binding agent is a resin comprising a polystyrene cross-linked chain structure formulated to sequestering sodium cations in the resin for later excretion. Methods of binding dietary sodium and treating or preventing hypernatremia in a hypertensive patient are also provided.

公开(公告)号：US11826724B2

公开(公告)日：2023-11-28

申请号：US17372985

申请日：2021-07-12

申请人： CytoSorbents Corporation

发明人： Tamaz Guliashvili ,  Thomas Golobish ,  Maryann Gruda ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vincent Capponi ,  Phillip Chan ,  Wei-Tai Young

IPC分类号： A61K38/00 ,  B01J20/26 ,  B01D15/34 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61K31/745 ,  A61M1/36 ,  B01D15/12

CPC分类号： B01J20/261 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/745 ,  A61M1/3679 ,  B01D15/34 ,  B01J20/262 ,  B01J20/267 ,  B01J20/2808 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/327 ,  B01J20/3208 ,  B01J20/3231 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289 ,  B01D15/125

摘要： The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US09782520B2

公开(公告)日：2017-10-10

申请号：US14347551

申请日：2012-09-26

申请人： BioSpheres, Inc.

发明人： William Wustenberg ,  Michael Finch ,  Cyrus B. Munshi

IPC分类号： A61L31/10 ,  A61L31/04 ,  A61K45/06 ,  A61K31/745 ,  A61K9/14 ,  A61L15/46 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L17/00 ,  A61K9/51 ,  A61K9/16

CPC分类号： A61L31/10 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5153 ,  A61K31/745 ,  A61K45/06 ,  A61L15/46 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2400/12

摘要： Compositions, implantation devices and methods for stimulating an immune response to infection are discussed. In some examples, the compositions, implantation devices or methods of regulating the amplification of an adaptive immune response to infection involves use of one or more particles locally at a surgical or implant site to control bacterial infections without detrimental systemic side-effects. In some examples, the particles can be coated or layered onto the surface of an implantable device or material. In other examples, the particles can be injected into the site of implantation.

公开(公告)号：US20170258824A1

公开(公告)日：2017-09-14

申请号：US15505589

申请日：2015-08-11

申请人： PERORA GMBH

发明人： Dirk VETTER

IPC分类号： A61K31/78 ,  A61K31/745 ,  A61K31/717 ,  A61K31/79 ,  A23L33/00 ,  A61K9/16 ,  A23L33/15 ,  A23L33/17 ,  A23L33/21 ,  A61K31/20 ,  A61K9/00

CPC分类号： A61K31/78 ,  A23L29/20 ,  A23L33/00 ,  A23L33/15 ,  A23L33/17 ,  A23L33/21 ,  A23L33/30 ,  A23V2002/00 ,  A61K9/0065 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/20 ,  A61K31/717 ,  A61K31/745 ,  A61K31/79 ,  G06F19/324 ,  G06F19/3456

摘要： The invention provides a method of inducing satiety in a subject comprising a step of orally administering a composition comprising an effective amount of a first agent capable of inducing satiety and of a second agent capable of augmenting the satiety-inducing effect of the first agent. Also disclosed are compositions for carrying out the method, and a body weight management system comprising such compositions in combination with a device configured for the collection, storage and/or display of information relating to a subject's response to a predefined therapeutic regimen of orally administering the composition.

公开(公告)号：US09717755B2

公开(公告)日：2017-08-01

申请号：US13637775

申请日：2011-04-01

申请人： Phillip P. Chan ,  Wei-Tai Young ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Robert H. Bartlett ,  Humayra Begum Ali

发明人： Phillip P. Chan ,  Wei-Tai Young ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Robert H. Bartlett ,  Humayra Begum Ali

IPC分类号： A61K31/745 ,  A61K31/74 ,  A61K31/75 ,  A61K9/00 ,  A61K47/48

CPC分类号： A61K31/745 ,  A61K9/0053 ,  A61K9/16 ,  A61K9/50 ,  A61K31/74 ,  A61K31/75 ,  A61K47/58 ,  B01J20/261 ,  B01J20/28004 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/3064 ,  C08F212/36 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2207/10 ,  C08J2325/02 ,  Y02A50/406 ,  Y02A50/411

摘要： The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.

公开(公告)号：US09655921B2

公开(公告)日：2017-05-23

申请号：US14912682

申请日：2015-12-22

申请人： Ardelyx, Inc.

发明人： Dominique Charmot ,  James P. Davidson ,  Fangling Lin ,  Jeffrey W. Jacobs ,  Natalia Blinova ,  Eric Labonte ,  Ingrid Langsetmo ,  Robert C. Blanks

IPC分类号： A61K31/795 ,  A61K9/00 ,  A61K47/12 ,  A61K47/26 ,  A61K9/10 ,  A61K31/745 ,  C08F8/36 ,  C08F8/44 ,  C08F220/22 ,  A61K9/16 ,  B01J39/20 ,  C08F257/00

CPC分类号： A61K31/795 ,  A61K9/0053 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/10 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/745 ,  A61K47/12 ,  A61K47/26 ,  B01J39/20 ,  C08F8/36 ,  C08F8/44 ,  C08F212/14 ,  C08F220/22 ,  C08F257/00 ,  C08F2800/10 ,  C08F212/08 ,  C08F212/36 ,  C08F236/20 ,  C08F8/12 ,  C08F222/20

摘要： The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.

公开(公告)号：US09603807B2

公开(公告)日：2017-03-28

申请号：US14025322

申请日：2013-09-12

申请人： University of Pittsburgh—Of the commonwealth System of Higher Education

发明人： John A. Kellum ,  Mitchell P. Fink

IPC分类号： A61K9/50 ,  A61K31/75 ,  A61K31/79 ,  A61K31/745 ,  A61K9/20 ,  A61K9/00

CPC分类号： A61K9/5026 ,  A61K9/0031 ,  A61K9/0065 ,  A61K9/2081 ,  A61K31/745 ,  A61K31/75 ,  A61K31/79 ,  Y02A50/411 ,  A61K2300/00

摘要： The invention provides a method of ameliorating inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to using these polymers as an enteral sorbent preparation to remove inflammatory mediators, such as cytokines, from the intestinal lumen. The polymers can be in the form of a preparation of polystyrene divinyl benzene copolymer beads with a biocompatible polyvinyl pyrrolidone polymer coating.

公开(公告)号：US20160287654A1

公开(公告)日：2016-10-06

申请号：US15154698

申请日：2016-05-13

申请人： REGENERA PHARMA LTD.

发明人： Zadik HAZAN

IPC分类号： A61K36/22

CPC分类号： A61K36/22 ,  A61K31/745

摘要： The invention relates to therapeutic uses of gum mastic, and compounds found therein including polymeric myrcene. More particularly, the invention relates to methods of treating impaired neurological function using compositions comprising polymeric myrcene.

公开(公告)号：US20150164785A1

公开(公告)日：2015-06-18

申请号：US14570972

申请日：2014-12-15

申请人： Bridgepoint Medical Inc.

发明人： Chad J. Kugler ,  Robert E. Atkinson ,  Peter T. Keith

IPC分类号： A61K9/00 ,  A61K31/78 ,  A61K33/00 ,  A61K31/765 ,  A61K31/785 ,  A61K31/75 ,  A61K31/745

CPC分类号： A61M31/002 ,  A61K9/0009 ,  A61K9/0012 ,  A61K9/0065 ,  A61K9/4808 ,  A61K9/4816 ,  A61K9/4891 ,  A61K31/745 ,  A61K31/75 ,  A61K31/765 ,  A61K31/78 ,  A61K31/785 ,  A61K33/00 ,  A61M2210/1042 ,  A61N5/062

摘要： Devices and methods for less invasively treating the gastrointestinal system, such as the intestinal mucosa of the small bowel. Embodiments described herein may be used to reduce caloric absorption and effectuate weight loss, for example.

摘要翻译： 用于较少侵入性治疗胃肠系统的装置和方法，例如小肠的肠粘膜。 例如，本文所述的实施方案可用于降低热量吸收和实现减肥。

公开(公告)号：US20150157779A1

公开(公告)日：2015-06-11

申请号：US14411665

申请日：2013-06-27

申请人： Fresenius Medicasl Care Deutschland GmbH

发明人： Dieter Falkenhagen ,  Jens Hartmann ,  Stephan Harm

IPC分类号： A61M1/34 ,  A61M1/36

CPC分类号： A61M1/3472 ,  A61K31/745 ,  A61K38/12 ,  A61M1/3486 ,  A61M1/3679 ,  A61M2202/0413 ,  A61M2202/0456 ,  A61M2202/049 ,  A61M2205/3303 ,  A61M2205/75 ,  B01J20/261 ,  B01J20/264 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28019 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/321 ,  B01J20/3214 ,  B01J20/3246 ,  B01J20/3274

摘要： Embodiments of the invention relate to an extracorporeal perfusion apparatus comprising an extracorporeal blood circuit for conveying blood, a filtrate circuit for conveying blood plasma, and a controller, wherein the filtrate circuit is connected to the extracorporeal blood circuit by means of a filter, wherein the filter has a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and wherein a depletion agent comprising a first carrier having a neutral, hydrophobic surface is arranged in the filtrate circuit, wherein the perfusion apparatus comprises a dispensing means for feeding an endotoxin-binding lipopeptide into the extracorporeal blood circuit, wherein the endotoxin-binding lipopeptide is selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof, and a combination thereof.