公开(公告)号：US06443884B1

公开(公告)日：2002-09-03

申请号：US09647860

申请日：2000-10-06

申请人： Fujio Miyawaki

发明人： Fujio Miyawaki

IPC分类号： A61N1362

CPC分类号： A61M1/1086 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1032 ,  A61M1/1037 ,  A61M1/106 ,  A61M1/1096 ,  A61M1/12 ,  A61M2205/3334

摘要： A ventricular assist device 10 includes a blood conduit 14, which carries the blood ejected from the ventricle to the ventricular assist device, a one-way valve 22, which is provided in the blood conduit and can open only toward the ventricular assist device, an afterload-controlling chamber 11, which temporarily stores the blood ejected from the ventricle, a pressure sensor 23, which measures the pressure in the afterload-controlling chamber, a blood pump 25 and a control unit 26 thereof, a blood conduit 16 that carries the blood to an artery, and a probe 27 for measuring blood flow rate and a flowmeter 28, which control the flow rate of the blood pump 25. The pressure of the afterload-controlling chamber 11 is controlled so as to keep the one-way valve closed during ventricular diastole, and also controlled so as to direct all the blood ejected from the ventricle into the afterload-controlling chamber 11 during ventricular systole. Therefore, a new ventricular assist device can be provided, which enables the native heart to eject blood with very low ejection resistance and ensures sufficient ventricular relaxation and filling.

摘要翻译： 心室辅助装置10包括：血液导管14，其将从脑室喷出的血液携带到心室辅助装置;单向阀22，其设置在血液导管中，并且仅能够朝向心室辅助装置打开， 临时存储从脑室喷射的血液的后负荷控制室11，测量后负荷控制室中的压力的​​压力传感器23，血液泵25及其控制单元26，血管16 血液到动脉，以及用于测量血液流量的探针27和控制血液泵25的流量的流量计28。控制后负荷控制室11的压力以保持单向阀 在心室舒张期间闭合，并且还被控制以便在心室收缩期间将从心室喷出的所有血液引导到后负荷控制室11中。 因此，可以提供新的心室辅助装置，这使得天然心脏以非常低的喷射阻力喷出血液并确保充分的心室松弛和充盈。

公开(公告)号：US08198072B2

公开(公告)日：2012-06-12

申请号：US11920550

申请日：2006-06-16

申请人： Fujio Miyawaki ,  Kenji Kobayashi ,  Jun Hasegawa

发明人： Fujio Miyawaki ,  Kenji Kobayashi ,  Jun Hasegawa

IPC分类号： C12M1/26 ,  G01N1/14 ,  H01L41/09

CPC分类号： C12M35/00

摘要： A vibration type microinjection device capable of ensuring smooth piercing of membranes having different properties such as a zona pellucida, a cell membrane and a nuclear membrane included in a fertilized egg with high accuracy and efficiency is provided.A vibration type microinjection device comprises a vibrator (28) which is connected in series with a micropipette (8) and which has a piezoelectric actuator (29) installed in a housing, and a signal control device (21) for controlling an electric signal applied to the piezoelectric actuator (29), wherein vibration is applied in the longitudinal direction of the micropipette (8) via the vibrator (28) by inputting an electric signal to the piezoelectric actuator (29). By such configuration, smooth piercing of membranes having different properties such as a zona pellucida, a cell membrane and nuclear membrane included in a fertilized egg is realized with high accuracy and efficiency.

摘要翻译： 本发明提供一种振动型显微注射装置，其能够确保高精度，高效率地包含于受精卵中的透明带，细胞膜，核膜等不同性质的膜的平滑穿刺。 一种振动型显微注射装置，包括与微量吸管（8）串联连接的振动器（28），并具有安装在外壳内的压电致动器（29），以及用于控制施加电信号的信号控制装置 到压电致动器（29），其中通过向压电致动器（29）输入电信号，经由振动器（28）在微量吸移管（8）的纵向上施加振动。 通过这样的结构，以高精度和高效率实现了具有不同性质的膜的透明透明膜，如透明带，细胞膜和受核卵中包含的核膜。

公开(公告)号：US20090130743A1

公开(公告)日：2009-05-21

申请号：US11920550

申请日：2006-06-16

申请人： Fujio Miyawaki ,  Kenji Kobayashi ,  Jun Hasegawa

发明人： Fujio Miyawaki ,  Kenji Kobayashi ,  Jun Hasegawa

IPC分类号： C12M1/26 ,  G01N1/14 ,  H01L41/09

CPC分类号： C12M35/00

摘要： A vibration type microinjection device capable of ensuring smooth piercing of membranes having different properties such as a zona pellucida, a cell membrane and a nuclear membrane included in a fertilized egg with high accuracy and efficiency is provided.A vibration type microinjection device comprises a vibrator (28) which is connected in series with a micropipette (8) and which has a piezoelectric actuator (29) installed in a housing, and a signal control device (21) for controlling an electric signal applied to the piezoelectric actuator (29), wherein vibration is applied in the longitudinal direction of the micropipette (8) via the vibrator (28) by inputting an electric signal to the piezoelectric actuator (29). By such configuration, smooth piercing of membranes having different properties such as a zona pellucida, a cell membrane and nuclear membrane included in a fertilized egg is realized with high accuracy and efficiency.

摘要翻译： 本发明提供一种振动型显微注射装置，其能够确保高精度，高效率地包含于受精卵中的透明带，细胞膜，核膜等不同性质的膜的平滑穿刺。 一种振动型显微注射装置，包括与微量吸管（8）串联连接的振动器（28），并具有安装在外壳内的压电致动器（29），以及用于控制施加电信号的信号控制装置 到压电致动器（29），其中通过向压电致动器（29）输入电信号，经由振动器（28）在微量吸移管（8）的纵向上施加振动。 通过这样的结构，以高精度和高效率实现了具有不同性质的膜的透明透明膜，如透明带，细胞膜和受核卵中包含的核膜。