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公开(公告)号：US11865164B2
公开(公告)日：2024-01-09
申请号：US17041670
申请日：2019-03-27
申请人： G+FLAS LIFE SCIENCES
发明人： Sunghwa Choe , Mi Jin Park , Aiden Yeonghoon Park , Jung Hak Lim , Dong Wook Kim , Sungyong In , Jongjin Park
IPC分类号： A61K48/00 , A61K38/46 , A61K47/64 , A61P35/00 , A61K31/7105
CPC分类号： A61K38/465 , A61K31/7105 , A61K47/64 , A61P35/00
摘要： A pharmaceutical composition for treating cancer, containing a crRNA and an endonuclease as active ingredients is disclosed. The composition can be customized according to the needs of patients or cell types by specifically treating cancer cells on the basis of specific binding properties of DNA and RNA. The nuclease activity of a CRISPR PLUS system, containing both an endonuclease and an exonuclease can be activated by means of the binding between crRNA and a gene specifically found in cancer cells. Therefore, the cancer treatment effect of the composition is more specific than that of other anti-cancer agents that have been developed up till now.
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公开(公告)号：US20210128697A1
公开(公告)日：2021-05-06
申请号：US17041670
申请日：2019-03-27
申请人： G+FLAS LIFE SCIENCES
发明人： Sunghwa CHOE , Mi Jin PARK , Aiden Yeonghoon PARK , Jung Hak LIM , Dong Wook KIM , Sungyong IN , Jongjin PARK
IPC分类号： A61K38/46 , A61K47/64 , A61K31/7105 , A61P35/00
摘要： A pharmaceutical composition for treating cancer, containing a crRNA and an endonuclease as active ingredients is disclosed. The composition can be customized according to the needs of patients or cell types by specifically treating cancer cells on the basis of specific binding properties of DNA and RNA. The nuclease activity of a CRISPR PLUS system, containing both an endonuclease and an exonuclease can be activated by means of the binding between crRNA and a gene specifically found in cancer cells. Therefore, the cancer treatment effect of the composition is more specific than that of other anti-cancer agents that have been developed up till now.
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公开(公告)号：US20210077594A1
公开(公告)日：2021-03-18
申请号：US17033313
申请日：2020-09-25
发明人： Sungyong IN , Sunghwa CHOE , Mi Jin PARK , Aiden Y. PARK , Jung Hak LIM , Dong Wook KIM , Youngdong YOO , Jongjin PARK
IPC分类号： A61K38/46 , A61K31/7052 , A61P35/00
摘要： Enhanced, specific nucleic acid targeting complexes comprising endo and exonuclease activity, and related methods that allow both targeted degradation of specific and/or non-specific nucleic acids in vivo and specific temporal regulation of nuclease activity to prevent off-target activity are disclosed herein. Through practice of the disclosure, nucleic acids, and cells harboring them, such as cancer cells or pathogens, are selectively degraded in vivo.
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公开(公告)号：US20210292722A1
公开(公告)日：2021-09-23
申请号：US17266882
申请日：2019-08-09
发明人： Sunghwa CHOE , Han Seong KIM , Dong Wook KIM , Jongjin PARK , Jiyoung YOON
IPC分类号： C12N9/22 , A61K38/46 , C12N15/11 , A61K31/7088
摘要： A novel CRISPR-associated protein and a use thereof are disclosed. A protein of the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 3 exhibits the activity of endonucleases, which recognize and cleave an intracellular nucleic acid sequence linked to a guide RNA. Therefore, a novel CRISPR-associated protein can be used as a different nuclease for genome editing, in a CRISPR-Cas system.
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公开(公告)号：US20210054362A1
公开(公告)日：2021-02-25
申请号：US16955639
申请日：2018-12-21
申请人： G+FLAS LIFE SCIENCES
发明人： Jongjin PARK , Ji Young YOON , Sunmee CHOI , Mijin PARK , Slki PARK , Aiden Y. PARK , Jung Hyuk LEE , Junghak LIM , Dong Wook KIM , Sunghwa CHOE
IPC分类号： C12N15/10 , C12N9/22 , C12N15/113
摘要： The present disclosure provides compositions and methods for increasing mutation efficiency and homologous recombination rates of site-specific endonucleases. The compositions and methods comprise a chimeric polypeptide comprising a site-specific endonuclease or a domain thereof and a functional moiety. The current inventions relate to functional enhancement of the CRISPR-Cas enzymes. Disclosed herein include possible variants and their intended improvements.
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公开(公告)号：US20230374478A1
公开(公告)日：2023-11-23
申请号：US18027598
申请日：2021-09-23
申请人： G FLAS LIFE SCIENCES
发明人： Jong Jin PARK , Jung Hyuk LEE
CPC分类号： C12N9/22 , C12N15/102 , C12N2310/20 , C07K2319/09
摘要： The present invention relates to a modified CRISPR-associated protein and a use thereof. More specifically, the present invention relates to a composition for genome editing comprising the modified CRISPR-associated protein and an enhancer, a method for genome editing using the same, and a method for producing a transformant by using the same. The modified CRISPR-associated protein according to the present invention is available as a nuclease having excellent indel efficiency in a CRISPR-Cas system, and exhibits excellent indel efficiency compared to conventional CRISPR-Cas systems, thus finding advantageous applications in genome editing.
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公开(公告)号：US20210243962A1
公开(公告)日：2021-08-12
申请号：US17271213
申请日：2019-07-25
申请人： G+FLAS Life Sciences
发明人： Gwang Man PARK
摘要： A system includes: a thermo-hygrostat provided in a room of a closed plant factory; a CO2 supply device supplying CO2 to the room; an outdoor air damper controlling a flow rate of an outdoor air introduced into the room; an exhaust damper controlling a flow rate of an indoor air discharged from the room; an air supply fan blowing the outdoor air introduced into the outdoor air damper; an exhaust fan blowing the indoor air discharged through the exhaust damper; an inducing fan provided on a ceiling of the room; an outdoor air sensor unit including an outdoor air temperature sensor, an outdoor air humidity sensor and an outdoor air CO2 sensor; an indoor sensor unit including an indoor temperature sensor, an indoor humidity sensor and an indoor CO2 sensor; a human body detection sensor; and a control unit.
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公开(公告)号：US20210222140A1
公开(公告)日：2021-07-22
申请号：US17171302
申请日：2021-02-09
发明人： Sunghwa CHOE , Jongjin PARK , Jiyoung YOON , Han Seong KIM , Dong Wook KIM
摘要： The present disclosure provides novel Cas12a proteins, which cleave target nucleic acids and methods of use thereof.
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公开(公告)号：US20210212269A1
公开(公告)日：2021-07-15
申请号：US17271212
申请日：2019-07-25
申请人： G+FLAS Life Sciences
发明人： Gwang Man PARK
摘要： A system for controlling an environment of an air conditioner-type closed plant factory includes: an outdoor air damper installed in an air supply duct; an exhaust damper installed in an exhaust duct; a circulating air damper installed in a connection duct for connecting the air supply duct and the exhaust duct; a CO2 supply device supplying CO2 to the air introduced into the room; a humidification coil humidifying the air introduced into the room; a cold and hot water coil heating or cooling the air introduced into the room; an outdoor air sensor unit including an outdoor air temperature sensor, an outdoor air humidity sensor, and an outdoor air CO2 sensor; an indoor sensor unit including an indoor temperature sensor, an indoor humidity sensor, and an indoor CO2 sensor; a human body detection sensor detecting a human body in the room; and a control unit.
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