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公开(公告)号:US08414899B2
公开(公告)日:2013-04-09
申请号:US12296428
申请日:2007-04-11
申请人: Irun R. Cohen , Hila Amir-Kroll , Noam Cohen , Gabriel Nussbaum
发明人: Irun R. Cohen , Hila Amir-Kroll , Noam Cohen , Gabriel Nussbaum
IPC分类号: A61K39/00 , A61K39/02 , A61K39/385 , A61K39/295 , A61K45/00 , A61K47/00
CPC分类号: A61K39/385 , A61K39/092 , A61K39/095 , A61K2039/5154 , A61K2039/5158 , A61K2039/6043 , Y02A50/484
摘要: The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. The compositions and methods include immunogenic conjugates containing peptide carriers derived from heat shock protein 60 (HSP60). The known synthetic peptide carrier, p458, provides significantly improved immunogenicity when provided as a multimeric conjugate comprising a plurality of peptide carrier units conjugated to each antigen. Cell vaccine compositions comprising antigen presenting cells loaded with multimeric p458 conjugates are also provided.
摘要翻译: 本发明提供具有增强的免疫原性的改进的疫苗组合物及其使用方法。 组合物和方法包括含有衍生自热休克蛋白60(HSP60)的肽载体的免疫原性缀合物。 当作为包含与每个抗原缀合的多个肽载体单元的多聚体缀合物提供时,已知的合成肽载体p458提供显着改善的免疫原性。 还提供了包含负载有多聚体p458缀合物的抗原呈递细胞的细胞疫苗组合物。
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公开(公告)号:US08771759B2
公开(公告)日:2014-07-08
申请号:US13055081
申请日:2009-07-15
IPC分类号: A61K36/00
CPC分类号: A61K36/185 , A61K9/0014 , A61K31/14 , A61K31/4425 , A61K36/23 , A61K36/28 , A61K36/35 , A61K47/18 , A61K2300/00
摘要: Provided, among other things, is a method of treating or ameliorating an indication of non-mucosal topical tissue comprising periodically applying to such disease affected tissue a composition comprising: an effective amount of an appropriate composition of herbal bioactive comprising active(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea, and an effective amount of a quaternary ammonium surfactant.
摘要翻译: 除其他之外,提供了治疗或改善非粘膜局部组织的适应症的方法,包括周期性地向所述疾病影响组织施加组合物,所述组合物包含:有效量的草药生物活性物质的合适组合物,其包含一种或多种活性物质 或更多的黑曲霉,积雪草或紫锥菊,以及有效量的季铵表面活性剂。
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公开(公告)号:US20110151032A1
公开(公告)日:2011-06-23
申请号:US13055081
申请日:2009-07-15
CPC分类号: A61K36/185 , A61K9/0014 , A61K31/14 , A61K31/4425 , A61K36/23 , A61K36/28 , A61K36/35 , A61K47/18 , A61K2300/00
摘要: Provided, among other things, is a method of treating or ameliorating an indication of non-mucosal topical tissue comprising periodically applying to such disease affected tissue a composition comprising: an effective amount of an appropriate composition of herbal bioactive comprising active(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea, and an effective amount of a quaternary ammonium surfactant.
摘要翻译: 除其他之外,提供了治疗或改善非粘膜局部组织的适应症的方法,包括周期性地向所述疾病影响组织施加组合物,所述组合物包含:有效量的草药生物活性物质的合适组合物,其包含一种或多种活性物质 或更多的黑曲霉,积雪草或紫锥菊,以及有效量的季铵表面活性剂。
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公开(公告)号:US20090269370A1
公开(公告)日:2009-10-29
申请号:US12296428
申请日:2007-04-11
申请人: Irun R. Cohen , Hila Amir-Kroll , Noam Cohen , Gabriel Nussbaum
发明人: Irun R. Cohen , Hila Amir-Kroll , Noam Cohen , Gabriel Nussbaum
IPC分类号: A61K39/385 , C07K7/00 , C07K14/00 , C07K16/18
CPC分类号: A61K39/385 , A61K39/092 , A61K39/095 , A61K2039/5154 , A61K2039/5158 , A61K2039/6043 , Y02A50/484
摘要: The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. The compositions and methods include immunogenic conjugates containing peptide carriers derived from heat shock protein 60 (HSP60). The known synthetic peptide carrier, p458, provides significantly improved immunogenicity when provided as a multimeric conjugate comprising a plurality of peptide carrier units conjugated to each antigen. Cell vaccine compositions comprising antigen presenting cells loaded with multimeric p458 conjugates are also provided.
摘要翻译: 本发明提供具有增强的免疫原性的改进的疫苗组合物及其使用方法。 组合物和方法包括含有衍生自热休克蛋白60(HSP60)的肽载体的免疫原性缀合物。 当作为包含与每个抗原缀合的多个肽载体单元的多聚体缀合物提供时,已知的合成肽载体p458提供显着改善的免疫原性。 还提供了包含负载有多聚体p458缀合物的抗原呈递细胞的细胞疫苗组合物。
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