公开(公告)号：US06596697B2

公开(公告)日：2003-07-22

申请号：US09945539

申请日：2001-08-30

申请人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

发明人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

IPC分类号： A61K3170

CPC分类号： A61K31/70 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  C07H15/252

摘要： According to the invention there is provided a sterile, pyrogen-free, ready-to-use solution of an anthracycline glycoside, especially doxorubicin, which consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable solvent therefor, which has not been reconstituted from a lyophilizate and which has a pH of from 2.5 to 6.5. The solution of the invention is particularly advantageous for the administration by injection of the anthracycline glycoside drugs, e.g. doxorubicin, in the treatment of both human and animal tumors.

公开(公告)号：US06087340A

公开(公告)日：2000-07-11

申请号：US149381

申请日：1998-09-08

申请人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

发明人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/70 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  B65D83/04 ,  C07H15/252

CPC分类号： A61K9/0019 ,  A61K31/70 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K9/08 ,  C07H15/252

摘要： A sealed glass container containing therein a stable, injectable, sterile, pyrogen-free doxorubicin anti-tumor composition in a solution which consists essentially of a physiologically acceptable salt of doxorubicin dissolved in a physiologically acceptable solvent therefor, wherein said solution has not been reconstituted from a lyophilizate, and wherein said solution has a pH of from 2.5-3.5 and a concentration of said doxorubicin of from 0.1 to 100 mg/ml.

公开(公告)号：US4675311A

公开(公告)日：1987-06-23

申请号：US788158

申请日：1985-10-16

申请人： Gaetano Gatti ,  Diego Oldani ,  Carlo Confalonieri ,  Luciano Gambini

发明人： Gaetano Gatti ,  Diego Oldani ,  Carlo Confalonieri ,  Luciano Gambini

IPC分类号： A61K31/70 ,  A61K9/08 ,  A61K9/19 ,  A61K31/704 ,  A61K47/00 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61P35/00 ,  A61K31/71

CPC分类号： A61K31/70 ,  A61K47/12 ,  A61K47/14 ,  A61K47/183 ,  A61K47/20 ,  A61K9/0019 ,  A61K9/19

摘要： Stable, rapidly soluble, lyophilized injectable preparations comprising an anthracycline glycoside, or a pharmaceutically acceptable salt thereof, as the active drug substance, and use of said preparations in the treatment of tumors.

摘要翻译： 包含蒽环类苷或其药学上可接受的盐作为活性药物的稳定，快速溶解，冻干的可注射制剂，以及所述制剂用于治疗肿瘤的用途。

公开(公告)号：US07005421B2

公开(公告)日：2006-02-28

申请号：US10454275

申请日：2003-06-04

申请人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

发明人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

IPC分类号： A61K31/70

CPC分类号： A61K31/70 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  C07H15/252

摘要： According to the invention there is provided a sterile, pyrogen-free, ready-to-use solution of an anthracycline glycoside, especially doxorubicin, which consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable solvent therefor, which has not been reconstituted from a lyophilizate and which has a pH of from 2.5 to 6.5. The solution of the invention is particularly advantageous for the administration by injection of the anthracycline glycoside drugs. e.g. doxorubicin, in the treatment of both human and animal tumors.

摘要翻译： 根据本发明，提供了一种无菌，无热原的即用型蒽环类苷，尤其是多柔比星的溶液，其主要由在其生理学上可接受的溶剂中溶解的蒽环类苷的生理上可接受的盐组成， 没有从冻干物重构，其pH为2.5至6.5。 本发明的溶液对于通过注射蒽环苷类药物而给药是特别有利的。 例如 多柔比星，用于治疗人类和动物肿瘤。

公开(公告)号：US6107285A

公开(公告)日：2000-08-22

申请号：US827742

申请日：1992-01-29

申请人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

发明人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

IPC分类号： A61K9/08 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  C07H15/252 ,  A61K31/70

CPC分类号： A61K31/70 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K9/0019 ,  A61K9/08 ,  C07H15/252

摘要： According to the invention there is provided a sterile, pyrogen-free, ready-to-use solution of an anthracycline glycoside, especially doxorubicin, which consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable solvent therefor, which has not been reconstituted from a lyophilizate and which has a pH of from 2.5 to 6.5. The solution of the invention is particularly advantageous for the administration by injection of the anthracycline glycoside drugs, e.g. doxorubicin, in the treatment of both human and animal tumors.

公开(公告)号：US5977082A

公开(公告)日：1999-11-02

申请号：US368402

申请日：1995-01-03

申请人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

发明人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/70 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  B65D83/04 ,  C07H15/252

CPC分类号： A61K9/0019 ,  A61K31/70 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K9/08 ,  C07H15/252

摘要： A sealed glass container containing therein a stable, injectable, sterile, pyrogen-free doxorubicin anti-tumor composition in a solution which consists essentially of a physiologically acceptable salt of doxorubicin dissolved in a physiologically acceptable solvent therefor, wherein said solution has not been reconstituted from a lyophilizate, and wherein said solution has a pH of from 2.5-3.5 and a concentration of said doxorubicin of from 0.1 to 100 mg/ml.

公开(公告)号：US5124318A

公开(公告)日：1992-06-23

申请号：US471005

申请日：1990-01-25

申请人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

发明人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  C07H15/252

CPC分类号： A61K9/0019 ,  A61K31/70 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K9/08 ,  C07H15/252

摘要： A sealed glass container containing therein a stable, injectable, sterile, pyrogen-free doxorubicin anti-tumor composition in a solution which consists essentially of a physiologically acceptable salt of doxorubicin dissolved in a physiologically acceptable solvent therefor, wherein said solution has not been reconstructed from a lyophilizate, and wherein said solution has a pH of from 2.5-3.5 and a concentration of said doxorubicin of from 0.1 to 100 mg/ml.

摘要翻译： 一种密封的玻璃容器，其中含有稳定的，可注射的，无菌的无致热原多柔比星抗肿瘤组合物，其溶液中基本上由生理上可接受的多柔比星盐溶解在其生理上可接受的溶剂中，其中所述溶液未被重建 冻干物，其中所述溶液的pH为2.5-3.5，所述多柔比星的浓度为0.1至100mg / ml。

公开(公告)号：US5091372A

公开(公告)日：1992-02-25

申请号：US588526

申请日：1990-09-26

申请人： Gaetano Gatti ,  Diego Oldani ,  Carlo Confalonieri ,  Luciano Gambini

发明人： Gaetano Gatti ,  Diego Oldani ,  Carlo Confalonieri ,  Luciano Gambini

IPC分类号： A61K31/70 ,  A61K9/08 ,  A61K9/19 ,  A61K31/704 ,  A61K47/00 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61P35/00

CPC分类号： A61K31/70 ,  A61K47/12 ,  A61K47/14 ,  A61K47/183 ,  A61K47/20 ,  A61K9/0019 ,  A61K9/19

摘要： Stable, rapidly soluble, lyophilized injectable preparations comprising an anthracycline glycoside, or a pharmaceutically acceptable salt thereof, as the active drug substance, and use of said preparations in the treatment of tumors.

公开(公告)号：US4946831A

公开(公告)日：1990-08-07

申请号：US385999

申请日：1989-07-27

申请人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

发明人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonieri ,  Luciano Gambini ,  Roberto De Ponti

IPC分类号： A61K9/08 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K47/02 ,  A61K47/04 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61P35/00 ,  C07H15/252

CPC分类号： A61K31/70 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K9/0019 ,  A61K9/08 ,  C07H15/252

摘要： According to the invention there is provided a sterile, pyrogen-free, ready-to-use solution of an anthracycline glycoside, especially doxorubicin, which consists essentially of a physiologically acceptable salt of an anthracycline glycoside dissolved in a physiologically acceptable solvent therefor, which has not been reconstituted from a lyophilizate and which has a pH of from 2.5 to 6.5. The solution of the invention is particularly advantageous for the administration by injection of the anthracycline glycoside drugs, e.g. doxorubicin, in the treatment of both human and animal tumors.

公开(公告)号：US06632799B2

公开(公告)日：2003-10-14

申请号：US09902030

申请日：2001-07-10

申请人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonier ,  Luciano Gambini ,  Roberto De Ponti

发明人： Gaetano Gatti ,  Diego Oldani ,  Giuseppe Bottoni ,  Carlo Confalonier ,  Luciano Gambini ,  Roberto De Ponti

IPC分类号： A61K3170

CPC分类号： A61K9/0019 ,  A61K9/08 ,  A61K31/70 ,  A61K31/704 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  C07H15/252

摘要： A sealed glass container containing therein a stable, injectable, sterile, pyrogen-free doxorubicin anti-tumor composition in a solution which consists essentially of a physiologically acceptable salt of doxorubicin dissolved in a physiologically acceptable solvent therefor, wherein said solution has not been reconstituted from a lyophilizate, and wherein said solution has a pH of from 2.5-3.5 and a concentration of said doxorubicin of from 0.1 to 100 mg/ml.

摘要翻译： 一种密封的玻璃容器，其中含有稳定的，可注射的，无菌的无热原的多柔比星抗肿瘤组合物，其溶液中基本上由溶解在其生理上可接受的溶剂中的多柔比星的生理上可接受的盐组成，其中所述溶液未被重新配制 一种冻干物，其中所述溶液的pH为2.5-3.5，所述多柔比星的浓度为0.1至100mg / ml。