公开(公告)号：US06833380B2

公开(公告)日：2004-12-21

申请号：US10324278

申请日：2002-12-19

Applicant: Xue-Min Cheng ,  Noe Erasga ,  Gary Frederick Filzen ,  Andrew Geyer ,  Chitase Lee ,  Bharat Kalidas Trivedi

Inventor： Xue-Min Cheng ,  Noe Erasga ,  Gary Frederick Filzen ,  Andrew Geyer ,  Chitase Lee ,  Bharat Kalidas Trivedi

IPC: A61K3142

CPC classification number: C07D417/12 ,  C07D277/26

Abstract: This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.

Abstract translation: 本发明公开了改变PPAR活性的化合物。 本发明还公开了化合物的药学上可接受的盐，包含化合物或其盐的药学上可接受的组合物，以及使用它们作为治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。 本发明还公开了制备所公开的化合物的方法。