公开(公告)号：US06509163B1

公开(公告)日：2003-01-21

申请号：US09638857

申请日：2000-08-15

申请人： Gary Nutter Buell ,  Annmarie Surprenant ,  Eric Kawashima

发明人： Gary Nutter Buell ,  Annmarie Surprenant ,  Eric Kawashima

IPC分类号： G01N3353

CPC分类号： C07K14/705

摘要： The present invention relates, in general, to a purinergic receptor and, particular, to a P2X7 (also designated P2Z) receptor. The invention further relates to a nucleic acid encoding the P2X7 receptor and to a method of producing P2X7 combinantly using same. The invention also relates to a method of screening compounds for their ability to inhibit P2X7 activity and thereby for their usefulness in treating a variety of diseases/disorders, including arthritic and respiratory disorders and neurodegenerative diseases.

摘要翻译： 本发明一般涉及嘌呤能受体，特别涉及P2X7（也称为P2Z）受体。 本发明还涉及编码P2X7受体的核酸和使用其组合生产P2X7的方法。 本发明还涉及一种筛选化合物抑制P2X7活性的能力的方法，从而其可用于治疗各种疾病/病症，包括关节炎和呼吸障碍和神经变性疾病。

公开(公告)号：US6133434A

公开(公告)日：2000-10-17

申请号：US842079

申请日：1997-04-28

申请人： Gary Nutter Buell ,  Annmarie Surprenant ,  Eric Kawashima

发明人： Gary Nutter Buell ,  Annmarie Surprenant ,  Eric Kawashima

IPC分类号： C07K14/705 ,  C07H21/00 ,  C07K14/475

CPC分类号： C07K14/705

摘要： The present invention relates, in general, to a purinergic receptor and, in particular, to a P2X.sub.7 (also designated P2Z) receptor. The invention further relates to a nucleic acid encoding the P2X.sub.7 receptor and to a method of producing P2X.sub.7 recombinantly using same. The invention also relates to a method of screening compounds for their ability to inhibit P2X.sub.7 activity and thereby for their usefulness in treating a variety of diseases/disorders, including arthritic and respiratory disorders and neurodegenerative diseases.

摘要翻译： 本发明一般涉及嘌呤能受体，特别涉及P2X7（也称为P2Z）受体。 本发明还涉及编码P2X7受体的核酸和使用其重组的P2X7的生产方法。 本发明还涉及一种筛选化合物抑制P2X7活性的能力的方法，从而其可用于治疗各种疾病/病症，包括关节炎和呼吸障碍和神经变性疾病。