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公开(公告)号：US06620801B2
公开(公告)日：2003-09-16
申请号：US09895395
申请日：2001-07-02
申请人： C. Edgar Cook , John A. Kepler , Gary S. Bartley , Rupa S. Shetty
发明人： C. Edgar Cook , John A. Kepler , Gary S. Bartley , Rupa S. Shetty
IPC分类号： A61K3158
摘要： The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
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2.发明授权17.beta.-nitro-11.beta.-arylisteroids and their derivatives having agonist or antagonist hormonal properties 有权17β-硝基-11β-芳醚甾族化合物及其衍生物具有激动剂或拮抗剂的激素特性
公开(公告)号：US6015805A
公开(公告)日：2000-01-18
申请号：US317945
申请日：1999-05-25
IPC分类号： A61K31/56 , A61K31/58 , A61K45/06 , A61P15/00 , A61P35/00 , A61P43/00 , C07J41/00 , C07J43/00
摘要： The invention is directed to 11.beta.-arylsteroids of formula II: ##STR1## wherein R.sup.1, R.sup.6, R.sup.8, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.
摘要翻译： 本发明涉及式II的11β-芳基甾族化合物：其中R1，R6，R8，R12和X如本说明书所定义。 这些化合物显示出有力的抗雌激素活性，并且可用于治疗子宫肌瘤，子宫内膜异位症，分娩前的子宫颈成熟，激素替代疗法和控制生育力。
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3.发明授权17β-amino and hydroxylamino-11 β-arylsteroids and their derivatives having agonist or antagonist hormonal properties 有权17β-氨基和羟氨基-11β-芳基甾族化合物及其衍生物具有激动剂或拮抗剂激素特性公开(公告)号：US07018991B2
公开(公告)日：2006-03-28
申请号：US10611785
申请日：2003-07-02
申请人： C. Edgar Cook , John A. Kepler , Gary S. Bartley , Rupa S. Shetty
发明人： C. Edgar Cook , John A. Kepler , Gary S. Bartley , Rupa S. Shetty
摘要： The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
摘要翻译： 本发明涉及一种新型的类固醇，其表现出有力的抗雌激素活性。
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公开(公告)号：US06541508B2
公开(公告)日：2003-04-01
申请号：US09802739
申请日：2001-03-09
IPC分类号： A61K31337
CPC分类号： A61K31/704 , A61K31/335 , A61K31/70 , A61K33/24 , A61K45/06 , A61K47/60 , Y02A50/411 , A61K2300/00
摘要： Taxane prodrugs comprise a taxane joined by a hydrolyzable bond to one or more oligomers that comprise a polyethylene glycol moiety. The oligomer preferably further comprises a salt-forming moiety.
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公开(公告)号：US06380405B1
公开(公告)日：2002-04-30
申请号：US09476974
申请日：1999-12-31
IPC分类号： C07D30514
CPC分类号： A61K33/24 , A61K45/06 , A61K47/60 , Y02A50/411 , A61K2300/00
摘要： The present invention generally provides taxane prodrugs comprising at least one taxane joined by hydrolyzable bond(s) to one or more polyethylene glycol oligomer(s) selected from the group consisting of a straight or branched polyethylene glycol oligomer having from 1 to 25 polyethylene glycol units and optionally comprising a salt-forming moiety. The polyethylene glycol oligomer preferably comprises a salt-forming moiety, which is preferably selected from the group consisting of ammonium and carboxylate.
摘要翻译： 本发明通常提供紫杉烷前药，其包含至少一种紫杉烷类，其通过可水解键连接到一种或多种选自具有1至25个聚乙二醇单元的直链或支链聚乙二醇低聚物的聚乙二醇低聚物 并且任选地包含成盐部分。 聚乙二醇低聚物优选包含成盐部分，其优选选自铵和羧酸盐。
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6.发明授权17&bgr;-amino and hydroxylamino-11&bgr;-arylsteroids and their derivatives having agonist or antagonist hormonal properties 失效17β-氨基和羟氨基-11β-芳基甾族化合物及其衍生物具有激动剂或拮抗剂的激素特性公开(公告)号：US06262042B1
公开(公告)日：2001-07-17
申请号：US09086560
申请日：1998-05-29
申请人： C. Edgar Cook , John A. Kepler , Gary S. Bartley
发明人： C. Edgar Cook , John A. Kepler , Gary S. Bartley
IPC分类号： A61K3156
摘要： The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
摘要翻译： 本发明涉及一种新型的类固醇，其表现出有力的抗雌激素活性。
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7.发明授权17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties 失效17β-硝基-11β-芳族甾族化合物及其衍生物具有激动剂或拮抗剂激素特性
公开(公告)号：US5962444A
公开(公告)日：1999-10-05
申请号：US86674
申请日：1998-05-29
IPC分类号： A61K31/56 , A61K31/58 , A61K45/06 , A61P15/00 , A61P35/00 , A61P43/00 , C07J41/00 , C07J43/00
摘要： The invention is directed to 17.beta.-nitro-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.
摘要翻译： 本发明涉及17种式I的β-硝基-11β-芳基甾族化合物：其中R1，R6，R7，R12和X如本说明书所定义。 这些化合物显示出有力的抗雌激素活性，并且可用于治疗子宫肌瘤，子宫内膜异位症，分娩前的子宫颈成熟，激素替代疗法和控制生育力。
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8.发明授权17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties 有权17β-硝基-11β-芳族甾族化合物及其衍生物具有激动剂或拮抗剂激素特性
公开(公告)号：US6093707A
公开(公告)日：2000-07-25
申请号：US434473
申请日：1999-11-05
IPC分类号： A61K31/56 , A61K31/58 , A61K45/06 , A61P15/00 , A61P35/00 , A61P43/00 , C07J41/00 , C07J43/00
摘要： The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
摘要翻译： 本发明涉及一种新型的类固醇，其表现出有力的抗雌激素活性。
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