公开(公告)号：US08574597B2

公开(公告)日：2013-11-05

申请号：US12004869

申请日：2007-12-21

申请人： Gary Warren Zlotnick

发明人： Gary Warren Zlotnick

IPC分类号： A61K39/095 ,  A61K39/02 ,  A61K39/116 ,  A61K39/00 ,  A61K39/385 ,  A61K38/00 ,  C07K1/00

CPC分类号： A61K39/095 ,  A61K2039/541 ,  C07K14/22

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：US20110189187A1

公开(公告)日：2011-08-04

申请号：US12004869

申请日：2007-12-21

申请人： Gary Warren Zlotnick

发明人： Gary Warren Zlotnick

IPC分类号： A61K39/395 ,  C12N15/31 ,  C12N15/63 ,  C12N1/00 ,  C07K14/22 ,  A61K38/16 ,  A61K39/095 ,  C07K16/12 ,  A61K31/7052 ,  C12N15/00 ,  A61P31/04 ,  A61P37/04

CPC分类号： A61K39/095 ,  A61K2039/541 ,  C07K14/22

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

摘要翻译： 本发明涉及奈瑟氏菌ORF2086蛋白质，其可以从胎儿菌株分离或重组制备的交联反应性免疫原性蛋白质，包括其免疫原性部分，其生物等同物，免疫特异性结合前述的抗体和编码上述每一种的核酸序列，作为 以及在针对脑膜炎奈瑟氏球菌血清群B感染有效的免疫原性组合物中的用途。