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公开(公告)号：US08133888B2
公开(公告)日：2012-03-13
申请号：US12918985
申请日：2009-02-12
申请人： Jiten Ranchhodbhai Patel , Gopalkumar Chimanlal Patel , Gaurav Sanjivkumar Sheth , Trinadha Rao Chitturi , Rajamannar Thennati
发明人： Jiten Ranchhodbhai Patel , Gopalkumar Chimanlal Patel , Gaurav Sanjivkumar Sheth , Trinadha Rao Chitturi , Rajamannar Thennati
IPC分类号： A61K31/337 , A61K31/4523 , A61K31/5377 , C07D305/14 , C07D405/12 , C07D413/12
CPC分类号： C07D305/14
摘要： The present invention relates to compounds of formula I or salts thereof, wherein, R1 is selected from the group consisting of hydrogen and R4; R2 is selected from the group consisting of hydrogen, acetyl and R4; R3 is selected from the group consisting of alkyl, —O-alkyl, —NH-alkyl, aryl and heterocyclyl; R4 represents a moiety (A) wherein, X is selected from the group consisting of a single bond, alkylene, alkenylene, alkynylene, arylene or a heterocyclylene moiety; R5 and R6 are same or different and are independently selected from hydrogen, alkyl, aryl or heterocyclyl; or R5 and R6 may form together with the nitrogen atom to which they are attached a heterocyclyl ring system.
摘要翻译： 本发明涉及式I化合物或其盐，其中R 1选自氢和R 4; R2选自氢，乙酰基和R4; R 3选自烷基，-O-烷基，-NH-烷基，芳基和杂环基; R4表示部分（A），其中X选自单键，亚烷基，亚烯基，亚炔基，亚芳基或亚杂环基; R5和R6相同或不同，独立地选自氢，烷基，芳基或杂环基; 或者R 5和R 6可以与它们所连接的氮原子一起形成杂环基环系。
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公开(公告)号：US20110172226A1
公开(公告)日：2011-07-14
申请号：US12918985
申请日：2009-02-12
申请人： Jiten Ranchhodbhai Patel , Gopalkumar Chimanlal Patel , Gaurav Sanjivkumar Sheth , Trinadha Rao Chitturi , Rajamannar Thennati
发明人： Jiten Ranchhodbhai Patel , Gopalkumar Chimanlal Patel , Gaurav Sanjivkumar Sheth , Trinadha Rao Chitturi , Rajamannar Thennati
IPC分类号： A61K31/5377 , C07D305/14 , A61K31/337 , C07D413/12 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/4523 , A61P35/00
CPC分类号： C07D305/14
摘要： The present invention relates to compounds of formula I or salts thereof, wherein, R1 is selected from the group consisting of hydrogen and R4; R2 is selected from the group consisting of hydrogen, acetyl and R4; R3 is selected from the group consisting of alkyl, —O-alkyl, —NH-alkyl, aryl and heterocyclyl; R4 represents a moiety (A) wherein, X is selected from the group consisting of a single bond, alkylene, alkenylene, alkynylene, arylene or a heterocyclylene moiety; R5 and R6 are same or different and are independently selected from hydrogen, alkyl, aryl or heterocyclyl; or R5 and R6 may form together with the nitrogen atom to which they are attached a heterocyclyl ring system.
摘要翻译： 本发明涉及式I化合物或其盐，其中R 1选自氢和R 4; R2选自氢，乙酰基和R4; R 3选自烷基，-O-烷基，-NH-烷基，芳基和杂环基; R4表示部分（A），其中X选自单键，亚烷基，亚烯基，亚炔基，亚芳基或亚杂环基; R5和R6相同或不同，独立地选自氢，烷基，芳基或杂环基; 或者R 5和R 6可以与它们所连接的氮原子一起形成杂环基环系。
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公开(公告)号：US08785425B2
公开(公告)日：2014-07-22
申请号：US12180257
申请日：2008-07-25
申请人： Jiten Ranchhodbhai Patel , Gopalkumar Chimanlal Patel , Gaurav Sanjivkumar Sheth , Samir Rameshchandra Shah , Sanjay Nandlal Mandhane , Trinadha Rao Chitturi , Rajamannar Thennati
发明人： Jiten Ranchhodbhai Patel , Gopalkumar Chimanlal Patel , Gaurav Sanjivkumar Sheth , Samir Rameshchandra Shah , Sanjay Nandlal Mandhane , Trinadha Rao Chitturi , Rajamannar Thennati
CPC分类号： C07J31/006 , C07J3/005 , C07J17/00 , C07J41/0038 , C07J71/0015
摘要： The invention provides 11β-hydroxyandrosta-4-ene-3-one compounds of Formula I, or physiologically acceptable salts or solvates thereof: wherein R4 represents a moiety selected from a group consisting of (A), (B) and (C), with a proviso that when R4 represents moiety (C), Z is S:
摘要翻译： 本发明提供了式I的11-二羟基雄甾-4-烯-3-酮化合物或其生理学上可接受的盐或溶剂化物：其中R4代表选自（A），（B）和（C）的一部分， ，条件是当R 4表示部分（C）时，Z为S：
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公开(公告)号：US20090054388A1
公开(公告)日：2009-02-26
申请号：US12180257
申请日：2008-07-25
申请人： Jiten Ranchhodbhai Patel , Gopalkumar Chimanlal Patel , Gaurav Sanjivkumar Sheth , Samir Rameshchandra Shah , Sanjay Nandlal Mandhane , Trinadha Rao Chitturi , Rajamannar Thennati
发明人： Jiten Ranchhodbhai Patel , Gopalkumar Chimanlal Patel , Gaurav Sanjivkumar Sheth , Samir Rameshchandra Shah , Sanjay Nandlal Mandhane , Trinadha Rao Chitturi , Rajamannar Thennati
CPC分类号： C07J31/006 , C07J3/005 , C07J17/00 , C07J41/0038 , C07J71/0015
摘要： The invention provides 11β-hydroxyandrosta-4-ene-3-one compounds of Formula I, or physiologically acceptable salts or solvates thereof: wherein R4 represents a moiety selected from a group consisting of (A), (B) and (C), with a proviso that when R4 represents moiety (C), Z is S:
摘要翻译： 本发明提供了式I的11β-羟基雄甾-4-烯-3-酮化合物或其生理学上可接受的盐或溶剂化物：其中R4代表选自（A），（B）和（C）的一部分， 条件是当R 4表示部分（C）时，Z为S：
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