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公开(公告)号：US20070196478A1
公开(公告)日：2007-08-23
申请号：US11733507
申请日：2007-04-10
申请人： Geert Verreck , Lieven Baert
发明人： Geert Verreck , Lieven Baert
IPC分类号： A61K31/53 , A61K9/14 , A61K31/513 , A61K31/506
CPC分类号： A61K31/506 , A61K9/146 , A61K31/513 , A61K31/53
摘要： The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.
摘要翻译： 本发明涉及可以施用于患有病毒感染的哺乳动物，特别是人的抗病毒化合物的药物组合物。 这些组合物包含通过熔融挤出包含一种或多种抗病毒化合物和一种或多种合适的水溶性聚合物的混合物并随后研磨所述熔融挤出的混合物而获得的颗粒。
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公开(公告)号：US20060062809A1
公开(公告)日：2006-03-23
申请号：US10518987
申请日：2003-07-01
申请人： Karel Six , Geert Verreck , Jozef Peeters , Marcus Brewster , Guy Van Den Mooter
发明人： Karel Six , Geert Verreck , Jozef Peeters , Marcus Brewster , Guy Van Den Mooter
CPC分类号： A61K9/1635 , A61K9/146
摘要： Present invention provides solid dispersions comprising a poorly soluble bioactive compound dispersed in a polymer matrix characterized in that the polymer matrix comprises more than one polymer. Said solid dispersions effectively stabilize the dispersed compound while stimulating the solubilisation of the compound in an aquaeous environment.
摘要翻译： 本发明提供包含分散在聚合物基质中的难溶性生物活性化合物的固体分散体，其特征在于聚合物基质包含多于一种聚合物。 所述固体分散体有效地稳定分散的化合物，同时刺激化合物在水环境中的溶解。
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公开(公告)号：US07887845B2
公开(公告)日：2011-02-15
申请号：US11347071
申请日：2006-02-03
申请人： Geert Verreck , Lieven Baert
发明人： Geert Verreck , Lieven Baert
IPC分类号： A61K9/14
CPC分类号： A61K31/506 , A61K9/146 , A61K31/513 , A61K31/53
摘要： The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.
摘要翻译： 本发明涉及可以施用于患有病毒感染的哺乳动物，特别是人的抗病毒化合物的药物组合物。 这些组合物包含通过熔融挤出包含一种或多种抗病毒化合物和一种或多种合适的水溶性聚合物的混合物并随后研磨所述熔融挤出的混合物而获得的颗粒。
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公开(公告)号：US20060127487A1
公开(公告)日：2006-06-15
申请号：US11347071
申请日：2006-02-03
申请人： Geert Verreck , Lieven Baert
发明人： Geert Verreck , Lieven Baert
IPC分类号： A61K9/14 , A61K31/53 , A61K31/506
CPC分类号： A61K31/506 , A61K9/146 , A61K31/513 , A61K31/53
摘要： The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.
摘要翻译： 本发明涉及可以施用于患有病毒感染的哺乳动物，特别是人的抗病毒化合物的药物组合物。 这些组合物包含通过熔融挤出包含一种或多种抗病毒化合物和一种或多种合适的水溶性聚合物的混合物并随后研磨所述熔融挤出的混合物而获得的颗粒。
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公开(公告)号：US06365188B1
公开(公告)日：2002-04-02
申请号：US09081808
申请日：1998-05-20
IPC分类号： A61K914
CPC分类号： B82Y5/00 , A61K9/1694 , A61K47/6951
摘要： Process for preparing a solid mixture comprising one or more cyclodextrins and an insoluble active ingredient characterized in that said process comprises a melt-extrusion step, wherein the active ingredient is embedded into the cyclodextrin carrier.
摘要翻译： 制备包含一种或多种环糊精和不溶性活性成分的固体混合物的方法，其特征在于所述方法包括熔融挤出步骤，其中活性成分嵌入到环糊精载体中。
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公开(公告)号：US07407670B2
公开(公告)日：2008-08-05
申请号：US10518987
申请日：2003-07-01
IPC分类号： A61K9/14
CPC分类号： A61K9/1635 , A61K9/146
摘要： Present invention provides solid dispersions comprising a poorly soluble bioactive compound dispersed in a polymer matrix characterized in that the polymer matrix comprises more than one polymer. Said solid dispersions effectively stabilize the dispersed compound while stimulating the solubilisation of the compound in an aquaeous environment.
摘要翻译： 本发明提供包含分散在聚合物基质中的难溶性生物活性化合物的固体分散体，其特征在于聚合物基质包含多于一种聚合物。 所述固体分散体有效地稳定分散的化合物，同时刺激化合物在水环境中的溶解。
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公开(公告)号：US20050158385A1
公开(公告)日：2005-07-21
申请号：US11077680
申请日：2005-03-11
申请人： Geert Verreck , Joel Rosenblatt , Alfred Liland
发明人： Geert Verreck , Joel Rosenblatt , Alfred Liland
CPC分类号： A61K9/2095 , A61K9/2086 , A61K9/2893
摘要： The present invention relates to a multi-layered, physiologically tolerated oral dosage form for pharmaceutically active compounds. The dosage form comprises a central core, a middle layer, and an outer shell, at least one of which includes at least one pharmaceutically active substance. By varying the diameter of the core, a different middle layer volume is obtained within a fixed outer shell dimension. This gives the ability to obtain different dosage strengths for one composition without the need of reformulation work. The oral dosage form is produced in a single-step, continuous process by coating the core with the middle layer and the outer shell.
摘要翻译： 本发明涉及用于药物活性化合物的多层生理耐受的口服剂型。 剂型包含中心核心，中间层和外壳，其中至少一个包括至少一种药物活性物质。 通过改变芯的直径，在固定的外壳尺寸内获得不同的中间层体积。 这使得能够为一种组合物获得不同的剂量强度，而不需要重新配制工作。 口服剂型通过用中间层和外壳涂覆核心，以单步连续方法生产。
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公开(公告)号：US06342245B1
公开(公告)日：2002-01-29
申请号：US09530170
申请日：2000-04-24
申请人： Lieven Baert , Geert Verreck
发明人： Lieven Baert , Geert Verreck
IPC分类号： A61K948
CPC分类号： A61K9/146
摘要： The present invention is concerned with novel pharmaceutical compositions of lipid lowering agents which can be administered to a mammal suffering from hyperlipidemia, obesitas or atherosclerosis, whereby a single such dosage form can be administered once daily, and in addition at any time of the day independently of the food taken in by said mammal. These novel compositions comprise particles obtainable by melt-extruding a mixture comprising a lipid lowering agent and an appropriate water-soluble polymer and subsequently milling said melt-extruded mixture.
摘要翻译： 本发明涉及可以向患有高脂血症，肥胖或动脉粥样硬化的哺乳动物施用的降脂药的新型药物组合物，由此可以每天一次施用单一的这种剂型，另外在一天中的任何时间独立地施用 的哺乳动物摄入的食物。 这些新型组合物包含通过熔融挤出包含降脂剂和合适的水溶性聚合物的混合物并随后研磨所述熔融挤出的混合物而获得的颗粒。
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公开(公告)号：US08591948B2
公开(公告)日：2013-11-26
申请号：US11445849
申请日：2006-06-01
IPC分类号： A61K9/36 , A61K9/20 , A61K9/28 , A61K9/30 , A61K31/497
CPC分类号： A61K9/146 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2866 , A61K31/496
摘要： The present invention is concerned with novel pharmaceutical compositions of itraconazole which can be administered to a mammal suffering from a fungal infection, whereby a single such dosage form can be administered once daily, and in addition at any time of the day independently of the food taken in by said mammal. These novel compositions comprise particles obtainable by melt-extruding a mixture comprising itraconazole and an appropriate water-soluble polymer and subsequently milling said melt-extruded mixture.
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公开(公告)号：US07241458B1
公开(公告)日：2007-07-10
申请号：US10088805
申请日：2000-08-31
申请人： Geert Verreck , Lieven Baert
发明人： Geert Verreck , Lieven Baert
IPC分类号： A61K9/14 , A61K9/20 , A61K9/50 , A61K31/505 , A01N43/54
CPC分类号： A61K31/506 , A61K9/146 , A61K31/513 , A61K31/53
摘要： The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.
摘要翻译： 本发明涉及可以施用于患有病毒感染的哺乳动物，特别是人的抗病毒化合物的药物组合物。 这些组合物包含通过熔融挤出包含一种或多种抗病毒化合物和一种或多种合适的水溶性聚合物的混合物并随后研磨所述熔融挤出的混合物而获得的颗粒。
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