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    Medicaments
    1.
    发明授权
    Medicaments 失效
    药剂

    公开(公告)号：US06569883B1

    公开(公告)日：2003-05-27

    申请号：US09305194

    申请日：1999-05-05

    申请人： Michael Brian Tyers ,  Ian Harold Coates ,  David Cedric Humber ,  George Blanch Ewan ,  James Angus Bell

    发明人： Michael Brian Tyers ,  Ian Harold Coates ,  David Cedric Humber ,  George Blanch Ewan ,  James Angus Bell

    IPC分类号： A61K31415

    CPC分类号： A61K31/4178 ,  A61K31/415 ,  Y10S514/966

    摘要： The invention relates to the use of compounds of the general formula (I) wherein R1 represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-(C1-4)alkyl, C3-6 alkenyl, C3-10 alkynyl, phenyl or phenyl-C1-3 alkyl group; and one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6 alkyl, C3-7cycloalkyl, C2-6 alkenyl or phenyl-C1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting and/or the promotion of gastric emptying and for the manufacture of a medicament for this purpose.

    摘要翻译： 本发明涉及通式（I）的化合物，其中R 1表示氢原子或C 1-10烷基，C 3-7环烷基，C 3-7环烷基 - （C 1-4）烷基，C 3-6烯基，C 3 -10炔基，苯基或苯基-C 1-3烷基; 由R 2，R 3和R 4表示的基团之一是氢原子或C 1-6烷基，C 3-7环烷基，C 2-6烯基或苯基-C 1-3烷基，其它两个基团可以是 相同或不同，代表氢原子或C1-6烷基;及其生理上可接受的盐和溶剂合物，用于缓解恶心和呕吐和/或促进胃排空和用于制造用于此目的的药物 。

    Medicaments for treating nausea and vomiting
    3.
    发明授权
    Medicaments for treating nausea and vomiting 失效
    用于治疗恶心和呕吐的药物

    公开(公告)号：US5922749A

    公开(公告)日：1999-07-13

    申请号：US689719

    申请日：1996-08-16

    申请人： Michael Brian Tyers ,  Ian Harold Coates ,  David Cedric Humber ,  George Blanch Ewan ,  James Angus Bell

    发明人： Michael Brian Tyers ,  Ian Harold Coates ,  David Cedric Humber ,  George Blanch Ewan ,  James Angus Bell

    IPC分类号： A61K31/415 ,  A61K31/4178

    CPC分类号： A61K31/4178 ,  A61K31/415 ,  Y10S514/966

    摘要： The invention relates to the use of compounds of the general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl-(C.sub.1-4) alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, phenyl or phenyl-C.sub.1-3 alkyl group; and one of the groups represented byR.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl or phenyl-C.sub.1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group;and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting and/or the promotion of gastric emptying and for the manufacture of a medicament for this purpose. Promotion of gastric emptying may be for the relief of gastro-intestinal disorders associated with gastric stasis or may be of advantage in radiological examination procedures.

    摘要翻译： 本发明涉及通式（I）的化合物，其中R 1表示氢原子或C 1-10烷基，C 3-7环烷基，C 3-7环烷基 - （C 1-4）烷基，C 3-6烯基， C 3-10炔基，苯基或苯基-C 1-3烷基; 由R 2，R 3和R 4表示的基团之一是氢原子或C 1-6烷基，C 3-7环烷基，C 2-6烯基或苯基-C 1-3烷基以及其它两个基团 相同或不同，表示氢原子或C1-6烷基; 及其生理上可接受的盐和溶剂化物，用于缓解恶心和呕吐和/或促进胃排空和用于制造用于此目的的药物。 促进胃排空可能是为了缓解与胃潴留相关的胃肠道疾病，或者在放射学检查程序中可能是有利的。