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    Medicaments
    1.
    发明授权
    Medicaments 失效
    药剂

    公开(公告)号：US06569883B1

    公开(公告)日：2003-05-27

    申请号：US09305194

    申请日：1999-05-05

    申请人： Michael Brian Tyers ,  Ian Harold Coates ,  David Cedric Humber ,  George Blanch Ewan ,  James Angus Bell

    发明人： Michael Brian Tyers ,  Ian Harold Coates ,  David Cedric Humber ,  George Blanch Ewan ,  James Angus Bell

    IPC分类号： A61K31415

    CPC分类号： A61K31/4178 ,  A61K31/415 ,  Y10S514/966

    摘要： The invention relates to the use of compounds of the general formula (I) wherein R1 represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-(C1-4)alkyl, C3-6 alkenyl, C3-10 alkynyl, phenyl or phenyl-C1-3 alkyl group; and one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6 alkyl, C3-7cycloalkyl, C2-6 alkenyl or phenyl-C1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting and/or the promotion of gastric emptying and for the manufacture of a medicament for this purpose.

    摘要翻译： 本发明涉及通式（I）的化合物，其中R 1表示氢原子或C 1-10烷基，C 3-7环烷基，C 3-7环烷基 - （C 1-4）烷基，C 3-6烯基，C 3 -10炔基，苯基或苯基-C 1-3烷基; 由R 2，R 3和R 4表示的基团之一是氢原子或C 1-6烷基，C 3-7环烷基，C 2-6烯基或苯基-C 1-3烷基，其它两个基团可以是 相同或不同，代表氢原子或C1-6烷基;及其生理上可接受的盐和溶剂合物，用于缓解恶心和呕吐和/或促进胃排空和用于制造用于此目的的药物 。

    Medicaments for treating nausea and vomiting
    2.
    发明授权
    Medicaments for treating nausea and vomiting 失效
    用于治疗恶心和呕吐的药物

    公开(公告)号：US5922749A

    公开(公告)日：1999-07-13

    申请号：US689719

    申请日：1996-08-16

    申请人： Michael Brian Tyers ,  Ian Harold Coates ,  David Cedric Humber ,  George Blanch Ewan ,  James Angus Bell

    发明人： Michael Brian Tyers ,  Ian Harold Coates ,  David Cedric Humber ,  George Blanch Ewan ,  James Angus Bell

    IPC分类号： A61K31/415 ,  A61K31/4178

    CPC分类号： A61K31/4178 ,  A61K31/415 ,  Y10S514/966

    摘要： The invention relates to the use of compounds of the general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl-(C.sub.1-4) alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, phenyl or phenyl-C.sub.1-3 alkyl group; and one of the groups represented byR.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl or phenyl-C.sub.1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group;and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting and/or the promotion of gastric emptying and for the manufacture of a medicament for this purpose. Promotion of gastric emptying may be for the relief of gastro-intestinal disorders associated with gastric stasis or may be of advantage in radiological examination procedures.

    摘要翻译： 本发明涉及通式（I）的化合物，其中R 1表示氢原子或C 1-10烷基，C 3-7环烷基，C 3-7环烷基 - （C 1-4）烷基，C 3-6烯基， C 3-10炔基，苯基或苯基-C 1-3烷基; 由R 2，R 3和R 4表示的基团之一是氢原子或C 1-6烷基，C 3-7环烷基，C 2-6烯基或苯基-C 1-3烷基以及其它两个基团 相同或不同，表示氢原子或C1-6烷基; 及其生理上可接受的盐和溶剂化物，用于缓解恶心和呕吐和/或促进胃排空和用于制造用于此目的的药物。 促进胃排空可能是为了缓解与胃潴留相关的胃肠道疾病，或者在放射学检查程序中可能是有利的。

    Medicaments for gastrointestinal disorders
    3.
    发明授权
    Medicaments for gastrointestinal disorders 失效
    胃肠道疾病药物

    公开(公告)号：US06544550B1

    公开(公告)日：2003-04-08

    申请号：US08156727

    申请日：1993-11-24

    申请人： Michael Brian Tyers ,  Teresa Elizabeth Challoner

    发明人： Michael Brian Tyers ,  Teresa Elizabeth Challoner

    IPC分类号： A61K948

    CPC分类号： A61K31/57 ,  A61K31/415 ,  A61K2300/00

    摘要： The invention relates to the co-administration in human or veterinary medicine of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or a physiologically acceptable salt or solvate thereof and dexamethasone or a physiologically acceptable salt or ester thereof. The two active ingredients, which may be administered separately either simultaneously or sequentially, or may be combined in a single pharmaceutical preparation, are useful in the relief and/or prevention of nausea and vomiting.

    摘要翻译： 本发明涉及人或兽医学中1,2,3,9-四氢-9-甲基-3 - [（2-甲基-1H-咪唑-1-基）甲基] -4H-咔唑的共同给药 -4-酮或其生理学上可接受的盐或溶剂化物，以及地塞米松或其生理上可接受的盐或酯。 可以单独或依次单独施用或可以组合在单一药物制剂中的两种活性成分可用于缓解和/或预防恶心和呕吐。