公开(公告)号：US5252560A

公开(公告)日：1993-10-12

申请号：US905933

申请日：1992-06-29

申请人： Peter L. Myers ,  Andrew B. McElroy ,  Michael Gregson ,  Peter J. Brown ,  Howard G. Davies ,  David H. Drewry ,  Michael A. Foley

发明人： Peter L. Myers ,  Andrew B. McElroy ,  Michael Gregson ,  Peter J. Brown ,  Howard G. Davies ,  David H. Drewry ,  Michael A. Foley

IPC分类号： A61K38/55 ,  A61K38/00 ,  A61P1/02 ,  A61P17/00 ,  A61P19/10 ,  A61P25/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D209/48 ,  C07D209/66 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  A61K37/02 ,  C07D413/12

CPC分类号： C07K5/0222 ,  A61K38/00

摘要： Compounds are described of the formula ##STR1## wherein: R.sup.1 is C.sub.3-6 alkyl or C.sub.1-3 alkylthioC.sub.1-3 alkyl;R.sup.2 is an optionally substituted C.sub.1-6 alkyl or C.sub.1-6 alkoxy group, aryl, heteroaryl, arylC.sub.1-4 alkyl, heteroarylC.sub.1-4 alkyl or a side-chain of a natural .alpha.-amino acid;R.sup.3 is hydrogen, C.sub.1-6 alkyl, CHR.sup.4 COR.sup.5 (where R.sup.4 is a side-chain of a natural .alpha.-amino acid and R.sup.5 is hydroxyl, C.sub.1-6 alkoxy or NHR.sup.6 where R.sup.6 represents a hydrogen atom or a C.sub.1-6 alkyl group) or a group (CH.sub.2).sub.n X (where n is 1 to 6 and X is hydroxyl, C.sub.1-4 alkoxy, heteroaryl or a group NR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are each hydrogen or C.sub.1-6 alkyl or the group NR.sup.7 R.sup.8 forms a 5 to 7 membered cyclic amine); andHet is an optionally substituted cyclic imide where the cyclic imide ring system has the formula (i), (ii) or (iii) ##STR2## in which A, B, C and D are each CH or 1 or 2 of A, B, C and D represents N and the others represent CH, and E and F may each independently represent CH or N; and physiologically acceptable salts and solvates thereof.These compounds inhibit metalloproteases involved in tissue degradation. Compounds of the invention may be formulated for use in a variety of conditions involving tissue degradation including arthropathy, dermatological conditions, bone resorption, inflammatory diseases, tumour invasion and multiple sclerosis and related diseases involving myelin degradation, and in the promotion of wound healing.

公开(公告)号：US4267320A

公开(公告)日：1981-05-12

申请号：US061260

申请日：1979-07-27

申请人： Michael Gregson ,  Richard B. Sykes

发明人： Michael Gregson ,  Richard B. Sykes

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B57/00 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/30 ,  C07D501/34 ,  C07D501/60

CPC分类号： C07D501/34

摘要： The invention provides novel antibiotic cefuroxime esters of the formula ##STR1## (wherein R.sup.1 is a primary or secondary alkyl group containing 1 to 4 carbon atoms and R.sup.2 is a primary or secondary alkyl group containing 1 to 6 carbon atoms provided that at least one of the groups R.sup.1 and R.sup.2 is methyl). These compounds are useful as orally administrable broad spectrum antibiotics.

摘要翻译： 本发明提供了新颖的式（IMAGE）抗生素头孢呋辛酯（其中R 1是含有1至4个碳原子的伯或仲烷基，R 2是含有1至6个碳原子的伯或仲烷基，条件是至少有一个 基团R 1和R 2是甲基）。 这些化合物可用作口服给药的广谱抗生素。

公开(公告)号：US4209616A

公开(公告)日：1980-06-24

申请号：US951761

申请日：1978-10-16

申请人： Michael Gregson ,  Martin C. Cook ,  Gordon I. Gregory

发明人： Michael Gregson ,  Martin C. Cook ,  Gordon I. Gregory

IPC分类号： C07C259/02 ,  C07D307/54 ,  C07D333/24 ,  C07D501/26 ,  C07D501/20

CPC分类号： C07D307/54 ,  C07C259/02 ,  C07D333/24

摘要： The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

摘要翻译： 本发明提供了新的抗生素化合物，它们是7β-酰基酰胺基头孢-3-烯-4-羧酸及其无毒衍生物，和6β-酰基氨基青蒿素-3-羧酸及其无毒衍生物，其特征在于 酰胺基具有结构

公开(公告)号：US3936443A

公开(公告)日：1976-02-03

申请号：US595105

申请日：1975-07-11

申请人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

发明人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

IPC分类号： C07D307/54 ,  C07D333/24 ,  C07D499/70

CPC分类号： C07D307/54 ,  C07D333/24

摘要： The invention provides novel antibiotic compounds which are 6.beta.-acylamidopenam-3-carboxylic acids and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##EQU1## WHERE R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

摘要翻译： 本发明提供了新颖的抗生素化合物，它们是6β-酰基氨基青蒿素-3-羧酸及其无毒的衍生物，其特征在于酰基酰胺基具有结构RCCONH PARALLEL N | ORA，其中R是氢原子或有机基团， Ra是氢原子或酰基。 这些化合物是顺式异构体，或作为含有至少75％的顺式异构体的混合物存在。 这些抗生素化合物对革兰氏阳性和革兰氏阴性生物体的一系列革兰氏阴性菌具有很高的抗菌活性，与各种革兰氏阴性生物产生的β-内酰胺酶具有特别高的稳定性。 本发明还涉及化合物的给药。

公开(公告)号：US06819655B1

公开(公告)日：2004-11-16

申请号：US09188923

申请日：1998-11-09

申请人： J. Michael Gregson

发明人： J. Michael Gregson

IPC分类号： G01R3108

CPC分类号： H04L43/18 ,  H04L43/028 ,  H04L43/045 ,  H04L43/067 ,  H04L43/0817 ,  H04L43/0847 ,  H04L43/0882 ,  H04L43/0894 ,  H04L43/10 ,  H04L43/12 ,  H04L43/14 ,  H04L67/42

摘要： A method and system for analyzing a public switched communications network from a remote place via the public Internet. The system comprises an access device which collects data from one or more links in a public switched communications network. The system further includes a server computer which receives the collected data from the access device via a dedicated network or the Internet. The server computer executes one or more applications to perform protocol analysis based on the received data. A client computer executing a Web browser may be used to communicate with the server computer via the Internet and access the outcome of the protocol analysis.

摘要翻译： 一种用于通过公共因特网从远程地点分析公共交换通信网络的方法和系统。 该系统包括从公共交换通信网络中的一个或多个链路收集数据的接入设备。 该系统还包括服务器计算机，其通过专用网络或因特网从接入设备接收收集的数据。 服务器计算机执行一个或多个应用以基于接收的数据执行协议分析。 执行Web浏览器的客户端计算机可以用于经由因特网与服务器计算机通信并访问协议分析的结果。

公开(公告)号：US5925624A

公开(公告)日：1999-07-20

申请号：US446727

申请日：1995-09-18

申请人： Michael Gregson ,  Barry Edward Ayres, deceased ,  George Blanch Ewan ,  Frank Ellis ,  John Knight

发明人： Michael Gregson ,  Barry Edward Ayres, deceased ,  George Blanch Ewan ,  Frank Ellis ,  John Knight

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P1/00 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P35/04 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08 ,  C07H19/16 ,  C07H19/167

CPC分类号： C07H19/16 ,  C07H19/167

摘要： The present invention relates to 2,6-diaminopurine-.beta.-D-ribofuranuronamide derivatives of the following formula (I). These compounds and their salts and solvates are useful as anti-inflammatory agents, particularly in the treatment of patients with inflammatory conditions who are susceptible to leukocyte-induced tissue damage. ##STR1##

摘要翻译： PCT No.PCT / EP94 / 00145 Sec。 371 1995年9月18日第 102（e）1995年9月18日PCT PCT 1994年1月18日PCT公布。 公开号WO94 / 17090 日期：1994年8月4日本发明涉及下式（I）的2,6-二氨基嘌呤-β-D-呋喃核糖酰胺衍生物。 这些化合物及其盐和溶剂化物可用作抗炎剂，特别是用于治疗易受白细胞诱导的组织损伤的炎性病症的患者。

公开(公告)号：US07072305B1

公开(公告)日：2006-07-04

申请号：US09430687

申请日：1999-10-29

申请人： J. Michael Gregson

发明人： J. Michael Gregson

IPC分类号： H04J1/16 ,  H04J3/14

CPC分类号： H04L1/24 ,  H04L41/0681 ,  H04L43/067 ,  H04L43/0829 ,  H04L43/0847 ,  H04L43/0852 ,  H04L43/106 ,  H04L43/16 ,  H04L43/50

摘要： A method and system for testing at least one link in a communications network. The system includes first and second analyzer units that are configured to test an existing link in the network. Alternatively, the first and second analyzer units may be configured to establish and test a link between them. A computer remotely controls the first and second analyzer units to perform testing of various communication parameters, such as packet loss and latency. Each analyzer unit may be configured to collect data over a predetermined duration to establish a network baseline of operation, which may be used to detect future network malfunctions. The computer estimates the deviation of communication parameters from the network baseline.

摘要翻译： 一种用于测试通信网络中的至少一个链路的方法和系统。 该系统包括被配置为测试网络中的现有链路的第一和第二分析器单元。 或者，第一和第二分析器单元可以被配置为建立和测试它们之间的链接。 计算机远程控制第一和第二分析器单元来执行各种通信参数的测试，例如分组丢失和延迟。 每个分析器单元可以被配置为在预定的持续时间内收集数据以建立操作的网络基线，其可以用于检测未来的网络故障。 计算机估计通信参数与网络基线的偏差。

公开(公告)号：US4385054A

公开(公告)日：1983-05-24

申请号：US259363

申请日：1981-04-30

申请人： Cynthia H. O'Callaghan ,  Michael Gregson

发明人： Cynthia H. O'Callaghan ,  Michael Gregson

IPC分类号： A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/08 ,  C07D501/34

CPC分类号： C07D501/34

摘要： Compounds of the general formula ##STR1## (wherein R represents a methyl or 2-chloroethyl group and * represents an asymmetric carbon atom). The above compounds are useful as orally administrable antibiotics.

摘要翻译： 通式（I）的化合物（其中R表示甲基或2-氯乙基，*表示不对称碳原子）。 上述化合物可用作可口服抗生素。

公开(公告)号：US4024134A

公开(公告)日：1977-05-17

申请号：US554014

申请日：1975-02-28

申请人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

发明人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

IPC分类号： C07C259/02 ,  C07D307/54 ,  C07D333/24 ,  C07D501/20

CPC分类号： C07C259/02 ,  C07D307/54 ,  C07D333/24

摘要： The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

摘要翻译： 本发明提供了新的抗生素化合物，它们是7β-酰基酰胺基头孢-3-烯-4-羧酸及其无毒衍生物，和6β-酰基氨基青蒿素-3-羧酸及其无毒衍生物，其特征在于 酰胺基具有结构

公开(公告)号：US5889178A

公开(公告)日：1999-03-30

申请号：US934540

申请日：1997-09-22

申请人： Michael Gregson ,  Barry Edward Ayres, deceased ,  George Blanch Ewan ,  Frank Ellis ,  John Knight

发明人： Michael Gregson ,  Barry Edward Ayres, deceased ,  George Blanch Ewan ,  Frank Ellis ,  John Knight

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P1/00 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P35/04 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08 ,  C07H19/16 ,  C07H19/167 ,  C07H19/00

CPC分类号： C07H19/16 ,  C07H19/167

摘要： The present invention relates to compounds of formula (IV): ##STR1## wherein R.sup.a and R.sup.b each represent a hydrogen atom or together form an alkylidene group.

摘要翻译： 本发明涉及式（Ⅳ）化合物：其中R a和R b各自代表氢原子或一起形成亚烷基。