公开(公告)号：US20100268219A1

公开(公告)日：2010-10-21

申请号：US12424287

申请日：2009-04-15

申请人： Theodore C. Ormsby ,  Russell Chung ,  George Leung ,  Gwo Jenn Shen

发明人： Theodore C. Ormsby ,  Russell Chung ,  George Leung ,  Gwo Jenn Shen

IPC分类号： A61B18/18

CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/1853 ,  A61B2018/1869

摘要： An ablation device which transmits radio frequency (RF) energy for the ablation of biological tissues has elongate inner and outer coaxial conductors extending from a proximal portion to a distal portion. An RF antenna is disposed at the distal portion of the device and transmits RF energy for ablation of a tissue region to be treated. Reflection of energy from the tissue or the ablation point is reduced by providing multiple layers of dielectric media about the antenna, or by providing a gradual transition point from the conductors to the antenna tip, by means of a longitudinally stepped dielectric layer transformer.

摘要翻译： 传输用于生物组织消融的射频（RF）能量的消融装置具有从近端部分延伸到远端部分的细长内部和外部同轴导体。 RF天线设置在装置的远端部分，并且传送RF能量以消除待治疗的组织区域。 通过在天线附近提供多层电介质介质，或者通过纵向阶梯介质层变压器，通过提供从导体到天线尖端的逐渐转变点来减少来自组织或消融点的能量的反射。

公开(公告)号：US20100268218A1

公开(公告)日：2010-10-21

申请号：US12424274

申请日：2009-04-15

申请人： Theodore C. Ormsby ,  Russell Chung ,  George Leung ,  Gwo Jenn Shen

发明人： Theodore C. Ormsby ,  Russell Chung ,  George Leung ,  Gwo Jenn Shen

IPC分类号： A61B18/18

CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/1869

摘要： An ablation system which transmits radio frequency (RF) energy for the ablation of biological tissues has a transmission line and an RF antenna disposed at the distal portion of the transmission line. An RF signal generator supplies RF energy to the proximal end of the cable for transmission to the antenna, and an electrically tunable transformer is connected between the signal generator and the antenna. The transformer is tuned based on detection of the reflected power level from the antenna so as to reduce or minimize reflected power, thereby increasing RF energy coupling between the antenna and tissue.

摘要翻译： 传输用于生物组织消融的射频（RF）能量的消融系统具有设置在传输线的远端部分的传输线和RF天线。 RF信号发生器将RF能量提供给电缆的近端以传输到天线，并且电可变变压器连接在信号发生器和天线之间。 基于从天线的反射功率电平的检测来调整变压器，以便减少或最小化反射功率，从而增加天线与组织之间的RF能量耦合。

公开(公告)号：US09326819B2

公开(公告)日：2016-05-03

申请号：US12424274

申请日：2009-04-15

申请人： Theodore C. Ormsby ,  Russell Chung ,  George Leung ,  Gwo Jenn Shen

发明人： Theodore C. Ormsby ,  Russell Chung ,  George Leung ,  Gwo Jenn Shen

IPC分类号： A61B18/18

CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/1869

摘要： An ablation system which transmits radio frequency (RF) energy for the ablation of biological tissues has a transmission line and an RF antenna disposed at the distal portion of the transmission line. An RF signal generator supplies RF energy to the proximal end of the cable for transmission to the antenna, and an electrically tunable transformer is connected between the signal generator and the antenna. The transformer is tuned based on detection of the reflected power level from the antenna so as to reduce or minimize reflected power, thereby increasing RF energy coupling between the antenna and tissue.

摘要翻译： 传输用于生物组织消融的射频（RF）能量的消融系统具有设置在传输线的远端部分的传输线和RF天线。 RF信号发生器将RF能量提供给电缆的近端以传输到天线，并且电可变变压器连接在信号发生器和天线之间。 基于从天线的反射功率电平的检测来调整变压器，以便减少或最小化反射功率，从而增加天线与组织之间的RF能量耦合。

公开(公告)号：US20080015570A1

公开(公告)日：2008-01-17

申请号：US11781467

申请日：2007-07-23

申请人： Theodore Ormsby ,  George Leung ,  Gwo Shen ,  Peter Chu ,  Ming Law

发明人： Theodore Ormsby ,  George Leung ,  Gwo Shen ,  Peter Chu ,  Ming Law

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2017/003 ,  A61B2018/00839 ,  A61B2018/00916 ,  A61B2018/00946 ,  A61B2018/183

摘要： A hollow coaxial cable adapted for conduction of radio frequency (RF) energy, particularly microwave energy, has a proximal end and a distal end and comprises coaxial inner and outer conductors extending substantially the entire length of the cable from the proximal end to a distal end portion of the cable with a dielectric medium disposed between the inner and outer conductors. The inner conductor comprises an elongated electrically conductive tubular member having a hollow, axially extending lumen, and the outer conductor comprises an elongated electrically conductive tubular member disposed in a substantially coaxial relationship over at least a portion of the inner conductor. An ablating member which delivers radio frequency energy, particularly microwave energy, to body tissue is disposed at a distal end portion of the cable.

摘要翻译： 适于传导射频（RF）能量，特别是微波能量的中空同轴电缆具有近端和远端，并且包括同轴的内部和外部导体，其基本上从近端延伸到远端的整个长度 电缆的一部分，其中介电介质设置在内导体和外导体之间。 内导体包括具有中空的轴向延伸的内腔的细长的导电管状构件，并且外导体包括在内导体的至少一部分上以基本上同轴的关系设置的细长的导电管状构件。 将电波能量，特别是微波能量传送到身体组织的消融部件设置在电缆的远端部分。

公开(公告)号：US08934989B2

公开(公告)日：2015-01-13

申请号：US12424287

申请日：2009-04-15

申请人： Theodore C. Ormsby ,  Russell Chung ,  George Leung ,  Gwo Jenn Shen

发明人： Theodore C. Ormsby ,  Russell Chung ,  George Leung ,  Gwo Jenn Shen

IPC分类号： A61F2/00 ,  A61B18/18

CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2018/1853 ,  A61B2018/1869

摘要： An ablation device which transmits radio frequency (RF) energy for the ablation of biological tissues has elongate inner and outer coaxial conductors extending from a proximal portion to a distal portion. An RF antenna is disposed at the distal portion of the device and transmits RF energy for ablation of a tissue region to be treated. Reflection of energy from the tissue or the ablation point is reduced by providing multiple layers of dielectric media about the antenna, or by providing a gradual transition point from the conductors to the antenna tip, by means of a longitudinally stepped dielectric layer transformer.

摘要翻译： 传输用于生物组织消融的射频（RF）能量的消融装置具有从近端部分延伸到远端部分的细长内部和外部同轴导体。 RF天线设置在装置的远端部分，并且传送RF能量以消除待治疗的组织区域。 通过在天线附近提供多层电介质介质，或者通过纵向阶梯介质层变压器，通过提供从导体到天线尖端的逐渐转变点来减少来自组织或消融点的能量的反射。

公开(公告)号：US5366870A

公开(公告)日：1994-11-22

申请号：US042417

申请日：1993-04-02

申请人： Gerald Odstrchel ,  George Leung

发明人： Gerald Odstrchel ,  George Leung

IPC分类号： C12Q1/52 ,  C12Q1/34 ,  G01N21/00

CPC分类号： C12Q1/52 ,  Y10S435/808 ,  Y10S435/81

摘要： Method for determining the presence of an aminotransferase (AT.sub.1), other than aspartate aminotransferase (AST), in a biological sample. The method includes contacting the sample with an amino donor substrate for AT.sub.1, an amino acceptor substrate for AT.sub.1, cysteine sulfinic acid (CSA) in excess, a second aminotransferase (AT.sub.2), different from AT.sub.1, in excess, and an indicator for the presence of sulfite ions, under conditions in which the concentration of said AT.sub.1 can be determined by the amount of the indicator which forms a detectable signal.

摘要翻译： 确定生物样品中天冬氨酸氨基转移酶（AST）以外的氨基转移酶（AT1）的存在的方法。 该方法包括将样品与AT1的氨基供体底物，AT1的氨基受体底物，过量的半胱氨酸亚磺酸（CSA），过量的与AT1不同的第二氨基转移酶（AT2）和用于存在的指示剂 的亚硫酸根离子，其中所述AT1的浓度可以由形成可检测信号的指示剂的量确定。

公开(公告)号：US08679106B2

公开(公告)日：2014-03-25

申请号：US12166159

申请日：2008-07-01

申请人： Theodore C. Ormsby ,  George Leung ,  Gwo Jenn Shen

发明人： Theodore C. Ormsby ,  George Leung ,  Gwo Jenn Shen

IPC分类号： A61B18/14

CPC分类号： A61F2/958 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00422 ,  A61B2018/1846 ,  A61B2018/1853 ,  A61B2018/1861

摘要： A coaxial cable apparatus which transmits radio frequency (RF) energy for the ablation of biological tissues has inner and outer coaxial conductors extending substantially the entire length of the cable from a proximal end portion to a distal end portion. An RF antenna is disposed at the distal end portion of the cable and transmits RF energy for ablation of a tissue region to be treated. An angioplasty balloon is disposed over the RF antenna and communicates with a fluid supply and extraction passageway extending through the cable to allow the balloon to be inflated for an angioplasty procedure including tissue ablation, and to be deflated after the procedure is complete.

摘要翻译： 传输用于生物组织消融的射频（RF）能量的同轴电缆装置具有从近端部分到远端部分的大致整个长度的电缆的内部和外部同轴导线。 RF天线设置在电缆的远端部分，并且传输RF能量以消除待治疗的组织区域。 血管成形术球囊设置在RF天线上方，并与延伸穿过电缆的流体供应和提取通道连通，以允许气囊膨胀用于包括组织消融的血管成形术程序，并且在手术完成之后被放气。

公开(公告)号：US20100004650A1

公开(公告)日：2010-01-07

申请号：US12166159

申请日：2008-07-01

申请人： Theodore C. Ormsby ,  George Leung ,  Gwo Jenn Shen

发明人： Theodore C. Ormsby ,  George Leung ,  Gwo Jenn Shen

IPC分类号： A61B18/18 ,  A61F2/84

CPC分类号： A61F2/958 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00422 ,  A61B2018/1846 ,  A61B2018/1853 ,  A61B2018/1861

摘要： A coaxial cable apparatus which transmits radio frequency (RF) energy for the ablation of biological tissues has inner and outer coaxial conductors extending substantially the entire length of the cable from a proximal end portion to a distal end portion. An RF antenna is disposed at the distal end portion of the cable and transmits RF energy for ablation of a tissue region to be treated. An angioplasty balloon is disposed over the RF antenna and communicates with a fluid supply and extraction passageway extending through the cable to allow the balloon to be inflated for an angioplasty procedure including tissue ablation, and to be deflated after the procedure is complete.

摘要翻译： 传输用于生物组织消融的射频（RF）能量的同轴电缆装置具有从近端部分到远端部分的大致整个长度的电缆的内部和外部同轴导线。 RF天线设置在电缆的远端部分，并且传输RF能量以消除待治疗的组织区域。 血管成形术球囊设置在RF天线上方，并与延伸穿过电缆的流体供应和提取通道连通，以允许气囊膨胀用于包括组织消融的血管成形术程序，并且在手术完成之后被放气。

公开(公告)号：US20070066972A1

公开(公告)日：2007-03-22

申请号：US11551162

申请日：2006-10-19

申请人： Theodore Ormsby ,  George Leung ,  Gwo Shen ,  Peter Chu

发明人： Theodore Ormsby ,  George Leung ,  Gwo Shen ,  Peter Chu

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2017/003 ,  A61B2018/00839 ,  A61B2018/00916 ,  A61B2018/00946 ,  A61B2018/183

摘要： A radio frequency (RF) ablation catheter has a flexible distal end portion so that it can be deflected to position an antenna disposed in the distal end portion adjacent a tissue site to be treated. At least one electrical conductor is coupled to the antenna and extends through the catheter to the proximal end of the catheter to a connector at the proximal end of the catheter for connection to a power supply for the RF antenna. At least one electrode is disposed at the distal end portion of the catheter and electrically coupled to the proximal end connector for connection to a monitor. The electrode is of a flexible, electrically conductive material such as conductive polymer material. The electrode may be an electrocardiogram (ECG) electrode.

摘要翻译： 射频（RF）消融导管具有柔性的远端部分，使得其可被偏转以定位邻近待治疗的组织部位的远端部分中的天线。 至少一个电导体被耦合到天线，并且通过导管延伸到导管的近端到在导管的近端处的连接器，用于连接到RF天线的电源。 至少一个电极设置在导管的远端部分处并且电耦合到近端连接器以连接到监视器。 电极是柔性的导电材料，例如导电聚合物材料。 电极可以是心电图（ECG）电极。

公开(公告)号：US20060287649A1

公开(公告)日：2006-12-21

申请号：US11479259

申请日：2006-06-30

申请人： Theodore Ormsby ,  George Leung ,  Gwo Shen ,  Peter Chu ,  Ming Fan Law

发明人： Theodore Ormsby ,  George Leung ,  Gwo Shen ,  Peter Chu ,  Ming Fan Law

IPC分类号： A61B18/04

CPC分类号： A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00256 ,  A61B2017/003 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00779 ,  A61B2018/00785 ,  A61B2018/00791 ,  A61B2018/00946

摘要： A radio-frequency based catheter system and method for ablating biological tissues within the body vessel of a patient comprises a radio-frequency (“RF”) generator for selectively generating a high frequency RF energy signal in a deployable catheter having an RF transmission line, an RF antenna mounted on the distal portion of the catheter, and a temperature sensor also mounted on a distal portion of the catheter for detecting temperature adjacent an ablation site. A control system adjusts the RF energy signal so that the detected temperature is at or close to a selected temperature setting or within a selected temperature range.