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1.发明申请公开(公告)号：US20170246269A1
公开(公告)日：2017-08-31
申请号：US15457660
申请日：2017-03-13
CPC分类号： A61K38/57 , A61K9/0063 , A61K38/08 , A61K38/1709 , A61K2039/505 , G01N33/502 , G01N33/6893 , G01N2800/18
摘要： The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also describes methods of screening for compounds that can be used to prevent or treat periodontitis or diseases associated with periodontitis.
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2.发明申请公开(公告)号：US20060182765A1
公开(公告)日：2006-08-17
申请号：US11354497
申请日：2006-02-15
IPC分类号： A61K39/02
CPC分类号： A61K39/39 , A61K2039/55544
摘要： The present invention provides a method for enhancing an immunological response to an antigen. The method comprises administering to an individual a composition comprising an antigen and an isolated LT-IIa-B pentamer or a mutant thereof, or an isolated LT-IIb-B pentamer or a mutant thereof. The selected LT-II-B pentamer acts as an adjuvant to enhance the immunological response to the co-administered antigen.
摘要翻译： 本发明提供增强对抗原的免疫应答的方法。 该方法包括向个体施用包含抗原和分离的LT-IIa-B五聚体或其突变体或分离的LT-IIb-B五聚体或其突变体的组合物。 选择的LT-II-B五聚体作为佐剂以增强对共同施用的抗原的免疫应答。
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公开(公告)号：US6030624A
公开(公告)日：2000-02-29
申请号：US912180
申请日：1997-08-15
申请人： Michael William Russell , Georgios Hajishengallis , Susan K. Hollingshead , Hong-Yin Wu , Suzanne Mary Michalek
发明人： Michael William Russell , Georgios Hajishengallis , Susan K. Hollingshead , Hong-Yin Wu , Suzanne Mary Michalek
CPC分类号： C12N15/62 , A61K39/092 , C07K14/28 , C07K14/315 , A61K2039/542 , A61K2039/6037 , C07K2319/00 , C07K2319/40 , C07K2319/55
摘要： The present invention provides chimeric proteins such as Salivary Binding Protein (SBR) coupled to the B subunit of cholera toxin. Such a chimeric protein, when expressed in attenuated Salmonella typhymurium produces significant increases in serum IgG and salivary IgA antibody levels after oral immunization. In another embodiment of the present invention, the recombinant plasmid contains a salivary binding protein-cholera toxin A2/B chimeric protein expressed in E. coli. Intragastric immunization of SBR coupled to CTB in this chimeric protein form leads to increased antigen responsive T cells. In another embodiment of the present invention, the recombinant plasmid contains a salivary binding protein-cholera toxin.sup..DELTA.A1 chimeric protein expressed in Salmonella typhimurium. Oral immunization using this recombinant plasmid results in increased serum IgG responses to antigen. Oral immunization using this recombinant plasmid also resulted in increased salivary IgA antibody responses to antigen.
摘要翻译： 本发明提供了与霍乱毒素B亚基偶联的嵌合蛋白如唾液结合蛋白（SBR）。 当在减毒的沙门氏菌中表达时，这种嵌合蛋白在口服免疫后产生血清IgG和唾液IgA抗体水平的显着增加。 在本发明的另一个实施方案中，重组质粒含有在大肠杆菌中表达的唾液结合蛋白 - 霍乱毒素A2 / B嵌合蛋白。 在该嵌合蛋白质形式中与CTB偶联的SBR的内部免疫导致增加的抗原应答性T细胞。 在本发明的另一个实施方案中，重组质粒含有在鼠伤寒沙门氏菌中表达的唾液结合蛋白 - 霍乱毒素DELTA A1嵌合蛋白。 使用这种重组质粒进行口服免疫可导致血清IgG对抗原的反应。 使用这种重组质粒的口服免疫也导致唾液IgA抗体对抗原的反应增加。
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4.发明申请公开(公告)号：US20220025028A1
公开(公告)日：2022-01-27
申请号：US17493158
申请日：2021-10-04
摘要： The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also describes methods of screening for compounds that can be used to prevent or treat periodontitis or diseases associated with periodontitis.
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5.发明申请METHODS OF TREATING OR PREVENTING PERIODONTITIS AND DISEASES ASSOCIATED WITH PERIODONTITIS 审中-公开治疗或预防与周期性相关的周期和疾病的方法公开(公告)号：US20130034568A1
公开(公告)日：2013-02-07
申请号：US13574542
申请日：2011-01-24
CPC分类号： A61K38/57 , A61K9/0063 , A61K38/08 , A61K38/1709 , A61K2039/505 , G01N33/502 , G01N33/6893 , G01N2800/18
摘要： The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also describes methods of screening for compounds that can be used to prevent or treat periodontitis or diseases associated with periodontitis.
摘要翻译： 本公开描述了预防或治疗牙周炎或与牙周炎相关的疾病的方法。 本公开还描述了可用于预防或治疗牙周炎或与牙周炎相关的疾病的化合物的筛选方法。
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