公开(公告)号：US20060159744A1

公开(公告)日：2006-07-20

申请号：US11385408

申请日：2006-03-21

Applicant: Gerard Alaux ,  Frederic Andre ,  Jean Ducassou ,  Gareth Lewis

Inventor： Gerard Alaux ,  Frederic Andre ,  Jean Ducassou ,  Gareth Lewis

IPC: A61K9/48 ,  A61K9/26

CPC classification number: A61K9/1676 ,  A61K9/2077 ,  A61K9/5026 ,  A61K9/5078 ,  A61K9/5084 ,  A61K31/437

Abstract: The present invention relates to timed dual release dosage forms of short acting hypnotics or salts thereof adapted to release the short acting hypnotic over a predetermined time period, according to a profile of dissolution characterized in that it comprises two release pulses, the first being immediate (lasting up to 30 minutes) and the second being delayed by a fixed time (this fixed time being between 50 and 200 minutes).

Abstract translation: 本发明涉及根据溶出曲线的适于在预定时间段内释放短暂催眠作用的短效催眠剂或其盐的定时双重释放剂型，其特征在于其包含两个释放脉冲，第一个是立即（ 持续长达30分钟），第二次延迟固定时间（固定时间在50到200分钟之间）。

公开(公告)号：US20080089936A1

公开(公告)日：2008-04-17

申请号：US11949291

申请日：2007-12-03

Applicant: Gerard ALAUX ,  Frederic ANDRE ,  Gareth LEWIS ,  Veronique SERRE

Inventor： Gerard ALAUX ,  Frederic ANDRE ,  Gareth LEWIS ,  Veronique SERRE

IPC: A61K9/22 ,  A61K31/506 ,  A61K31/454

CPC classification number: A61K9/209 ,  A61K9/2013 ,  A61K9/2054 ,  A61K31/437

Abstract: The invention concerns a novel formulation for prolonged release of an active principle having a pH-dependent solubility. The inventive formulation comprises a matrix support based on hydrophilic polymer containing a specific dose of active principle, and further comprises one or more acidifying agents in the form of an acid salt of an organic acid.

Abstract translation: 本发明涉及用于延长释放具有pH依赖性溶解度的活性成分的新型制剂。 本发明的制剂包含基于含有特定剂量的活性成分的亲水性聚合物的基质载体，并且还包含一种或多种有机酸的酸盐形式的酸化剂。

公开(公告)号：US20070190140A1

公开(公告)日：2007-08-16

申请号：US11675712

申请日：2007-02-16

Applicant: Gerard Alaux ,  Estelle Chouin ,  Nathalie Dufresne-Arokiassamy

Inventor： Gerard Alaux ,  Estelle Chouin ,  Nathalie Dufresne-Arokiassamy

IPC: A61K9/22 ,  A61K31/43 ,  A61K31/56 ,  A61K31/165 ,  A61K31/401 ,  A61K31/18

CPC classification number: A61K9/0065 ,  A61K9/2027 ,  A61K9/2086 ,  A61K31/517

Abstract: The disclosure concerns a pharmaceutical composition in the form of a gastric resident matrix tablet, comprising an active principle, characterized in that when contacted with an environment representing gastric fluid, it increases after 15 minutes in volume, by a swelling of at least 200%.

Abstract translation: 本公开内容涉及一种胃静脉曲张片剂形式的药物组合物，其包含活性成分，其特征在于，当与代表胃液的环境接触时，其在体积15分钟后增加至少200％的溶胀。