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    FINE NEEDLE ARRANGEMENT FOR CELL SAMPLING
    1.
    发明申请
    FINE NEEDLE ARRANGEMENT FOR CELL SAMPLING 有权
    细胞采样的精细布置

    公开(公告)号：US20100160828A1

    公开(公告)日：2010-06-24

    申请号：US12601074

    申请日：2008-05-20

    申请人： Hans Wiksell ,  Vilhelm Ekstrand ,  Gert Auer

    发明人： Hans Wiksell ,  Vilhelm Ekstrand ,  Gert Auer

    IPC分类号： A61B10/02

    CPC分类号： A61B10/0283 ,  A61B2090/3925

    摘要： Fine needle arrangement for taking a sample of cells from suspicious lesions by using fine needle aspiration (FNA) technique, including a tubular needle member (1), a storage compartment (2) enclosing a chamber, and a coupling (3) to which a connector may be attached. The chamber is configured with a gradually increasing cross-sectional area from the distal part of the chamber to the proximal part of the chamber, such that the chamber has no residual spaces where cell samples may be trapped, and that an efficient air streaming is achieved.

    摘要翻译： 细针布置用于通过使用细针抽吸（FNA）技术从可疑病变中取出细胞样品，包括管状针构件（1），封闭室的储存室（2）和耦合器（3） 连接器可以被连接。 腔室被构造成从腔室的远端部分到腔室的近端部分的逐渐增加的横截面面积，使得腔室没有残留空间，其中细胞样品可能被捕获，并且实现有效的空气流动 。

    Arrangement For Cell Sampling
    3.
    发明申请
    Arrangement For Cell Sampling 有权
    细胞取样方案

    公开(公告)号：US20080058671A1

    公开(公告)日：2008-03-06

    申请号：US11663723

    申请日：2005-09-21

    申请人： Hans Wiksell ,  Gert Auer ,  Vilhelm Ekstrand ,  Peter Harge

    发明人： Hans Wiksell ,  Gert Auer ,  Vilhelm Ekstrand ,  Peter Harge

    IPC分类号： A61B10/02

    CPC分类号： A61B10/0233 ,  A61B10/0041 ,  A61B10/0283 ,  A61B10/04 ,  A61B17/32002 ,  A61B17/320068 ,  A61B18/08 ,  A61B18/1477 ,  A61B2010/045 ,  A61B2018/1425

    摘要： An arrangement for taking a sample of cells from a suspicious lesion or a tumour with the so called fine needle aspiration technique, provides a good penetration of tumours, especially small and/or hard fibrous tumours, and in the meantime yielding an increased amount of cells in the sample, by applying a longitudinal movement to the needle when the needle is penetrating the tumour and by applying both a rotational and a longitudinal movement to the needle when the needle is positioned inside the tumour. The arrangement is further provided with heat generating elements in order to apply a short pulse of heat to the needle in order to lower the risk for the tumour to spread.

    摘要翻译： 用所谓的细针抽吸技术从可疑病变或肿瘤中取出细胞样品的装置提供了肿瘤，特别是小和/或硬纤维性肿瘤的良好渗透，并且同时产生增加量的细胞 在样品中，当针穿过肿瘤时通过向针施加纵向移动，并且当针位于肿瘤内时，通过同时向针施加旋转和纵向运动。 为了降低肿瘤扩散的风险，该装置还具有发热元件以便向针施加短脉冲的热量。

    Methods for detecting cervical cancer
    4.
    发明授权
    Methods for detecting cervical cancer 失效
    检测宫颈癌的方法

    公开(公告)号：US5919624A

    公开(公告)日：1999-07-06

    申请号：US781424

    申请日：1997-01-10

    申请人： Thomas Ried ,  Gert Auer ,  Evelin Schrock ,  Kerstin Heselmeyer ,  Merryn Macville

    发明人： Thomas Ried ,  Gert Auer ,  Evelin Schrock ,  Kerstin Heselmeyer ,  Merryn Macville

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/6886 ,  C12Q2600/112

    摘要： The invention provides a method of detecting the presence of invasive cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality which is associated with invasive cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of invasive cervical carcinoma in the subject. The invention also provides a method of detecting the presence of advanced-stage cervical carcinoma in a subject comprising detecting in a cervical cell from the subject the presence of a chromosome abnormality associated with advanced-stage cervical carcinoma; the presence of the cervical cell containing the chromosome abnormality indicating the presence of advanced-stage cervical carcinoma in the subject. The invention also provides a method of classifying the progression of dysplastic cervical cells from a non-invasive cervical carcinoma to an invasive cervical carcinoma comprising analyzing the dysplastic cervical cells for the presence of a chromosome abnormality which is associated with invasive cervical carcinoma, and classifying the dysplastic cervical cells having the chromosome abnormality as having progressed from a non-invasive cervical carcinoma cells to an invasive cervical carcinoma. The invention further provides kits comprising nucleic acids that specifically hybridize to chromosome 3q and specifically hybridize to another chromosome, and to compositions comprising nucleic acids.

    摘要翻译： 本发明提供一种检测受试者侵袭性宫颈癌存在的方法，包括在受试者宫颈细胞中检测与侵入性宫颈癌相关的染色体异常的存在; 含有染色体异常的子宫颈细胞的存在表明受试者存在浸润性宫颈癌。 本发明还提供一种检测受试者中晚期宫颈癌存在的方法，包括在受试者的子宫颈细胞中检测与晚期宫颈癌相关的染色体异常的存在; 含有染色体异常的子宫颈细胞的存在表明该受试者存在晚期宫颈癌。 本发明还提供了将发育不良的子宫颈细胞从非侵入性宫颈癌分级到浸润性宫颈癌的方法，包括分析发育不良的宫颈细胞是否存在与侵入性宫颈癌相关的染色体异常，并将 具有染色体异常的发育不良的宫颈细胞从非侵入性宫颈癌细胞进展到浸润性宫颈癌。 本发明还提供了包含与染色体3q特异性杂交并与另一染色体特异性杂交的核酸以及包含核酸的组合物的试剂盒。

    Arrangement for Taking a Sample of Bone Marrow and/or Evacuating the Sinuses
    6.
    发明申请
    Arrangement for Taking a Sample of Bone Marrow and/or Evacuating the Sinuses 审中-公开
    采取骨髓样本和/或排除窦炎的安排

    公开(公告)号：US20070270712A1

    公开(公告)日：2007-11-22

    申请号：US11664349

    申请日：2005-10-03

    申请人： Hans Wiksell ,  Gert Auer ,  Vilhelm Ekstrand ,  Eva Munck-Wikland ,  Peter Harge

    发明人： Hans Wiksell ,  Gert Auer ,  Vilhelm Ekstrand ,  Eva Munck-Wikland ,  Peter Harge

    IPC分类号： A61B10/02

    CPC分类号： A61B10/025 ,  A61B2010/0258 ,  A61B2018/00196 ,  A61B2018/1861 ,  A61B2090/034

    摘要： An arrangement for sinus evacuation and for taking a sample of bone marrow during a bone marrow aspiration procedure as well as a bone marrow biopsy procedure. By applying a longitudinal movement to the needle when the needle is penetrating the bone the penetration force is reduced which lower the risk of penetrating the posterior cortex or the second sinus wall. The arrangement further includes a stopping element that prevents the needle to penetrate deeper than to a predetermined depth. The arrangement further includes longitudinal movement a stopping element that provides for an active break of the longitudinal movement of the needle when the needle has penetrated down to the predetermined depth.

    摘要翻译： 在骨髓抽吸程序以及骨髓活检程序中用于窦排空和用于取骨髓样品的装置。 当针穿透骨头时，通过向针施加纵向移动，使得穿透力降低，这降低了穿透后皮层或第二窦壁的风险。 该装置还包括防止针穿透到比预定深度更深的止动元件。 该装置还包括纵向运动，当针已经穿透到预定深度时，提供针的纵向运动的主动断裂的止动元件。

    Fine needle arrangement for cell sampling
    7.
    发明授权
    Fine needle arrangement for cell sampling 有权
    细针取样细针排列

    公开(公告)号：US08323210B2

    公开(公告)日：2012-12-04

    申请号：US12601074

    申请日：2008-05-20

    申请人： Hans Wiksell ,  Vilhelm Ekstrand ,  Gert Auer

    发明人： Hans Wiksell ,  Vilhelm Ekstrand ,  Gert Auer

    IPC分类号： A61B10/00

    CPC分类号： A61B10/0283 ,  A61B2090/3925

    摘要： Fine needle arrangement for taking a sample of cells from suspicious lesions by using fine needle aspiration (FNA) technique, including a tubular needle member (1), a storage compartment (2) enclosing a chamber, and a coupling (3) to which a connector may be attached. The chamber is configured with a gradually increasing cross-sectional area from the distal part of the chamber to the proximal part of the chamber, such that the chamber has no residual spaces where cell samples may be trapped, and that an efficient air streaming is achieved.

    摘要翻译： 细针布置用于通过使用细针抽吸（FNA）技术从可疑病变中取出细胞样品，包括管状针构件（1），封闭室的储存室（2）和耦合器（3） 连接器可以被连接。 腔室被构造成从腔室的远端部分到腔室的近端部分的逐渐增加的横截面面积，使得腔室没有残留空间，其中细胞样品可能被捕获，并且实现有效的空气流动 。

    Arrangement for cell sampling
    9.
    发明授权
    Arrangement for cell sampling 有权
    细胞取样安排

    公开(公告)号：US07871383B2

    公开(公告)日：2011-01-18

    申请号：US11663723

    申请日：2005-09-21

    申请人： Hans Wiksell ,  Gert Auer ,  Vilhelm Ekstrand ,  Peter Harge

    发明人： Hans Wiksell ,  Gert Auer ,  Vilhelm Ekstrand ,  Peter Harge

    IPC分类号： A61B10/00

    CPC分类号： A61B10/0233 ,  A61B10/0041 ,  A61B10/0283 ,  A61B10/04 ,  A61B17/32002 ,  A61B17/320068 ,  A61B18/08 ,  A61B18/1477 ,  A61B2010/045 ,  A61B2018/1425

    摘要： An arrangement for taking a sample of cells from a suspicious lesion or a tumor with the so called fine needle aspiration technique, provides a good penetration of tumors, especially small and/or hard fibrous tumors, and in the meantime yielding an increased amount of cells in the sample, by applying a longitudinal movement to the needle when the needle is penetrating the tumor and by applying both a rotational and a longitudinal movement to the needle when the needle is positioned inside the tumor. The arrangement is further provided with heat generating elements in order to apply a short pulse of heat to the needle in order to lower the risk for the tumor to spread.

    摘要翻译： 用所谓的细针抽吸技术从可疑病变或肿瘤中取出细胞样品的装置提供了肿瘤，特别是小和/或硬纤维性肿瘤的良好渗透，并且同时产生增加量的细胞 在样品中，当针穿过肿瘤时通过向针施加纵向移动，并且当针位于肿瘤内时，通过同时向针施加旋转和纵向运动。 为了降低肿瘤扩散的风险，该装置还具有发热元件以便向针施加短脉冲的热量。

    ANTI-SEEDING ARRANGEMENT
    10.
    发明申请
    ANTI-SEEDING ARRANGEMENT 有权
    防止安置

    公开(公告)号：US20100228242A1

    公开(公告)日：2010-09-09

    申请号：US12294671

    申请日：2007-03-05

    申请人： Hans Wiksell ,  Gert Auer ,  Vilhelm Ekstrand

    发明人： Hans Wiksell ,  Gert Auer ,  Vilhelm Ekstrand

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1477 ,  A61B10/0233 ,  A61B18/1206 ,  A61B34/20 ,  A61B2018/00083 ,  A61B2018/0019 ,  A61B2018/00196 ,  A61B2018/00875 ,  A61B2018/1467

    摘要： The present invention relates to an anti-seeding arrangement (100) for invasive treatment of a human or animal body comprising an elongated hollow member (102), and a first electrode (116) of which one portion is arranged near one end of the elongated hollow member (102), said first electrode (116) being connectable to an electromagnetic field generator (110), wherein the elongated hollow member (102) is arranged to be inserted into the human or animal body, control means (106, 108) arranged to control the electromagnetic field generator (110) for delivering radio frequency bursts to the first electrode (116), and sensing means (104) to sense a physical property dependent on the insertion length of the elongated hollow member (102) in the human or animal body, and wherein the control means (106, 108) is arranged to control the operation of the electromagnetic field generator (110) in dependence of the sensed physical property.

    摘要翻译： 本发明涉及一种用于侵入性处理人体或动物体的防播种装置（100），其包括细长的中空构件（102）和第一电极（116），其中一个部分布置在细长的中空构件的一端附近 中空构件（102），所述第一电极（116）可连接到电磁场发生器（110），其中所述细长中空构件（102）布置成插入人体或动物体内，控制装置（106,108） 布置成控制用于将射频突发传送到第一电极（116）的电磁场发生器（110），以及感测装置（104），以感测取决于人体中的细长型中空构件（102）的插入长度的物理性质 或动物体，并且其中控制装置（106,108）被布置成根据检测到的物理特性来控制电磁场发生器（110）的操作。