公开(公告)号：US07674806B2

公开(公告)日：2010-03-09

申请号：US10568760

申请日：2004-09-16

Applicant: Marcello Allegretti ,  Maria Candida Cesta ,  Giuseppe Nano ,  Riccardo Bertini ,  Cinzia Bizzarri ,  Francesco Colotta

Inventor： Marcello Allegretti ,  Maria Candida Cesta ,  Giuseppe Nano ,  Riccardo Bertini ,  Cinzia Bizzarri ,  Francesco Colotta

IPC: C07D417/02 ,  C07D413/02 ,  A61K31/553 ,  A61K31/541 ,  A61K31/5377

CPC classification number: C07C309/65 ,  C07C257/14 ,  C07D211/26 ,  C07D233/10 ,  C07D273/04 ,  C07D333/24

Abstract: Amidines and derivatives thereof of formula (I) are described. The process for their preparation and pharmaceutical compositions thereof are also described. The amidines of the invention are useful in the inhibition of chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatement of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

Abstract translation: 描述了式（I）的脒及其衍生物。 还描述了其制备方法及其药物组合物。 本发明的脒可用于抑制IL-8诱导的嗜中性粒细胞趋化性。 本发明的化合物用于治疗牛皮癣，溃疡性结肠炎，黑素瘤，慢性阻塞性肺疾病（COPD），大疱性呼吸系统症，类风湿性关节炎，特发性纤维化，肾小球性肾炎，以及预防和治疗由缺血和再灌注引起的损伤。

公开(公告)号：US20070155717A1

公开(公告)日：2007-07-05

申请号：US10568760

申请日：2004-09-16

Applicant: Marcello Allegretti ,  Maria Cesta ,  Giuseppe Nano ,  Riccardo Bertini ,  Cinzia Bizzarri ,  Francesco Colotta

Inventor： Marcello Allegretti ,  Maria Cesta ,  Giuseppe Nano ,  Riccardo Bertini ,  Cinzia Bizzarri ,  Francesco Colotta

IPC: A61K31/553 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4245 ,  C07D417/02 ,  C07D413/02

CPC classification number: C07C309/65 ,  C07C257/14 ,  C07D211/26 ,  C07D233/10 ,  C07D273/04 ,  C07D333/24

Abstract: Amidines and derivatives thereof of formula (I) are described. The process for their preparation and pharmaceutical compositions thereof are also described. The amidines of the invention are useful in the inhibition of chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

Abstract translation: 描述了式（I）的脒及其衍生物。 还描述了其制备方法及其药物组合物。 本发明的脒可用于抑制IL-8诱导的嗜中性粒细胞趋化性。 本发明的化合物用于治疗牛皮癣，溃疡性结肠炎，黑素瘤，慢性阻塞性肺疾病（COPD），大疱性呼吸系统症，类风湿性关节炎，特发性纤维化，肾小球性肾炎，以及预防和治疗由缺血和再灌注引起的损伤。

公开(公告)号：US20140171723A1

公开(公告)日：2014-06-19

申请号：US14170629

申请日：2014-02-02

Applicant: Alberto Servida ,  Alessandro Servida ,  Simona Grassi ,  Giuseppe Nano

Inventor： Alberto Servida ,  Alessandro Servida ,  Simona Grassi ,  Giuseppe Nano

IPC: A62D3/38 ,  B09B3/00

CPC classification number: A62D3/38 ,  A62D3/20 ,  A62D2101/20 ,  A62D2101/41 ,  A62D2203/04 ,  A62D2203/10 ,  B09B3/0066

Abstract: A method for destroying asbestos in mainly organic matrix asbestos-containing waste includes the steps of: preparing the asbestos-containing waste; preparing a supercritical aqueous phase; letting the asbestos and the primarily organic matrix of the asbestos-containing waste react with the aqueous phase for a time t in an appropriate reactor at a predetermined pressure P and temperature T to maintain the aqueous phase in supercritical condition; cooling and condensing the aqueous phase flowing out of the reactor; and separating the aqueous phase from any entrained solid products therein. The step of preparing the supercritical aqueous phase includes an additional step, in which an oxidizing compound is added in a predetermined concentration Cl, the pressure P is in a range from 25 to 27 MPa, and the temperature T is in a range from 600° C. to 650° C., causing the asbestos and the organic binder to be simultaneously destroyed.

Abstract translation: 主要有机基质含石棉废物中破坏石棉的方法包括：制备含石棉废物; 制备超临界水相; 使石棉和含石棉废物的主要有机基质在适当的反应器中以预定的压力P和温度T与水相反应一段时间t，以将水相保持在超临界状态; 冷却并冷凝流出反应器的水相; 并将水相与其中夹带的固体产物分离。 制备超临界水相的步骤包括附加步骤，其中以预定浓度Cl加入氧化化合物，压力P在25-27MPa的范围内，温度T在600℃ C.到650℃，导致石棉和有机粘合剂同时被破坏。

公开(公告)号：US20100234667A1

公开(公告)日：2010-09-16

申请号：US12305960

申请日：2006-06-20

Applicant: Alberto Servida ,  Alessandro Servida ,  Simona Grassi ,  Giuseppe Nano

Inventor： Alberto Servida ,  Alessandro Servida ,  Simona Grassi ,  Giuseppe Nano

IPC: A62D3/20 ,  C02F1/72 ,  B09B3/00

CPC classification number: A62D3/38 ,  A62D3/20 ,  A62D2101/20 ,  A62D2101/41 ,  A62D2203/04 ,  A62D2203/10 ,  B09B3/0066

Abstract: A method for destroying asbestos in mainly organic matrix asbestos-containing waste (ACW), which includes the steps of: preparing the asbestos-containing waste; preparing a supercritical aqueous phase; allowing asbestos and the primarily organic matrix of the asbestos-containing waste to react with the aqueous phase for a time t in an appropriate reactor at predetermined pressure P and temperature T to maintain the aqueous phase in supercritical conditions; cooling and condensing the aqueous phase flowing out of the reactor; and separating said aqueous phase from any entrained solid product therein. The step in which the supercritical aqueous phase is prepared includes an additional step, in which at least one oxidizing compound is added in a predetermined concentration C1, the pressure P is in a range from 25 to 27 MPa, and the temperature T is in a range from 600° C. to 650° C., causing the asbestos and the organic binder to be simultaneously destroyed.

Abstract translation: 主要是有机基质含石棉废物（ACW）中破坏石棉的方法，其中包括以下步骤：制备含石棉废物; 制备超临界水相; 允许石棉和含石棉废物的主要有机基质在预定压力P和温度T下在合适的反应器中与水相反应一段时间t，以将水相保持在超临界条件下; 冷却并冷凝流出反应器的水相; 并将所述水相与其中夹带的固体产物分离。 制备超临界水相的步骤包括另外的步骤，其中以预定浓度C1加入至少一种氧化剂，压力P在25至27MPa的范围内，并且温度T为 范围从600℃到650℃，导致石棉和有机粘合剂同时被破坏。