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    Slurry process for phosphoromonochloridite synthesis
    1.
    发明授权
    Slurry process for phosphoromonochloridite synthesis 有权
    二氯化磷合成的淤浆法

    公开(公告)号：US08471066B2

    公开(公告)日：2013-06-25

    申请号：US12935095

    申请日：2009-03-17

    申请人： Glenn A. Miller

    发明人： Glenn A. Miller

    IPC分类号： C07F9/34

    CPC分类号： C07F9/6574

    摘要： A process for preparation of a phosphoromonochloridite in high yield, by contacting phosphorus trichloride (PCl3) with an aromatic diol, such as 2,2′-biphenol, in a slurry, which contains a portion of the aromatic diol in solid form and contains a solution phase containing the remaining portion of the aromatic diol and an organic solvent, under reaction conditions sufficient to produce the phosphoromonochloridite. The slurry comprises less than 5 mole percent of a nitrogen base, calculated on total moles of the aromatic diol, and the organic solvent is selected for its low hydrogen chloride solubility.

    摘要翻译： 通过使三氯化磷（PCl3）与芳族二醇例如2,2'-联苯酚在浆液中接触而制备高次聚合的一氯代磷酸酯的方法，该浆料含有固体形式的一部分芳族二醇，并含有 溶液相包含芳族二醇的剩余部分和有机溶剂，在足以产生一氯代亚硝酸酯的反应条件下。 浆料包含小于5摩尔％的氮碱，以芳族二醇的总摩尔数计算，并且选择有机溶剂以使其低氯化氢溶解度。

    SLURRY PROCESS FOR PHOSPHOROMONOCHLORIDITE SYTHESIS
    3.
    发明申请
    SLURRY PROCESS FOR PHOSPHOROMONOCHLORIDITE SYTHESIS 有权
    磷酸二氢钠合成的浆液过程

    公开(公告)号：US20110021840A1

    公开(公告)日：2011-01-27

    申请号：US12935095

    申请日：2009-03-17

    申请人： Glenn A. Miller

    发明人： Glenn A. Miller

    IPC分类号： C07F9/6571

    CPC分类号： C07F9/6574

    摘要： A process for preparation of a phosphoromonochloridite in high yield, by contacting phosphorus trichloride (PCl3) with an aromatic diol, such as 2,2′-biphenol, in a slurry, which contains a portion of the aromatic diol in solid form and contains a solution phase containing the remaining portion of the aromatic diol and an organic solvent, under reaction conditions sufficient to produce the phosphoromonochloridite. The slurry comprises less than 5 mole percent of a nitrogen base, calculated on total moles of the aromatic diol, and the organic solvent is selected for its low hydrogen chloride solubility.

    摘要翻译： 通过使三氯化磷（PCl3）与芳族二醇例如2,2'-联苯酚在浆液中接触而制备高次聚合的一氯代磷酸酯的方法，该浆料含有固体形式的一部分芳族二醇，并含有 溶液相包含芳族二醇的剩余部分和有机溶剂，在足以产生一氯代亚硝酸酯的反应条件下。 浆料包含小于5摩尔％的氮碱，以芳族二醇的总摩尔数计算，并且选择有机溶剂以使其低氯化氢溶解度。

    Hydroformylation process with improved control over product isomers
    4.
    发明授权
    Hydroformylation process with improved control over product isomers 有权
    加氢甲酰化方法改善了对产物异构体的控制

    公开(公告)号：US07863487B2

    公开(公告)日：2011-01-04

    申请号：US12530889

    申请日：2008-03-12

    申请人： Thomas C. Eisenschmid ,  Glenn A. Miller ,  Ronald R. Peterson ,  Anthony G. Abatjoglon

    发明人： Thomas C. Eisenschmid ,  Glenn A. Miller ,  Ronald R. Peterson ,  Anthony G. Abatjoglon

    IPC分类号： C07C45/50

    CPC分类号： C07C45/50 ,  C07C47/02

    摘要： A continuous hydroformylation process for producing a mixture of aldehydes with improved flexibility and stability of a normal/branched (N/I) isomer ratio of the product aldehydes. The process involves reacting one or more olefinically-unsaturated compounds with carbon monoxide and hydrogen in the presence of an organopolyphosphite ligand and an organomonophosphite ligand, at least one of such ligands being bonded to a transition metal to form a transition metal-ligand complex hydroformylation catalyst; the process being conducted at a sub-stoichiometric molar ratio of organopolyphosphite ligand to transition metal, at a super-stoichiometric (>2/1) molar ratio of organomonophosphite ligand to transition metal, and at a carbon monoxide partial pressure in the inverse order region of the hydroformylation rate curve; and controlling and varying the isomer ratio by varying the concentration of organopolyphosphite ligand relative to transition metal.

    摘要翻译： 用于产生醛的混合物的连续加氢甲酰化方法，其具有改进的产物醛的正常/支化（N / I）异构体比例的柔性和稳定性。 该方法包括在有机多亚磷酸酯配体和有机亚磷酸酯配体的存在下使一种或多种烯属不饱和化合物与一氧化碳和氢反应，至少一种这样的配体键合到过渡金属以形成过渡金属 - 配体络合物加氢甲酰化催化剂 ; 该方法以有机多亚磷酸酯配体与过渡金属的亚化学计量摩尔比以超化学计量比（> 2/1）的有机亚磷酸酯配体与过渡金属的摩尔比进行，并且在逆序区域中的一氧化碳分压 的加氢甲酰化速率曲线; 并通过改变有机多亚磷酸酯配体相对于过渡金属的浓度来控制和改变异构体比例。

    Enol-ether capped polyethers and surfactants produced therefrom
    6.
    再颁专利
    Enol-ether capped polyethers and surfactants produced therefrom 失效
    烯醇醚封端的聚醚及其制备的表面活性剂

    公开(公告)号：USRE37711E1

    公开(公告)日：2002-05-21

    申请号：US09370124

    申请日：1999-08-02

    申请人： Glenn A. Miller

    发明人： Glenn A. Miller

    IPC分类号： C08J902

    CPC分类号： C08J9/0061 ,  C08G77/46 ,  C08J2375/04 ,  C08J2483/00

    摘要： The use of enol ether capped polyether-polysiloxane copolymers as surfactants in polyurethane foam applications is taught herein. These enol ether capped surfactants exhibit a high capping efficiency and yield good performance. Moreover, they are stable in water/amine premixes.

    摘要翻译： 本文教导了在聚氨酯泡沫塑料应用中使用烯醇醚封端的聚醚 - 聚硅氧烷共聚物作为表面活性剂。 这些烯醇醚封端的表面活性剂具有高的封盖效率并产生良好的性能。 此外，它们在水/胺预混物中稳定。

    Method for nucleotide sequence amplification
    7.
    发明授权
    Method for nucleotide sequence amplification 失效
    核苷酸序列扩增方法

    公开(公告)号：US5545539A

    公开(公告)日：1996-08-13

    申请号：US326432

    申请日：1994-10-18

    申请人： Glenn A. Miller

    发明人： Glenn A. Miller

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/00

    CPC分类号： C12Q1/6848 ,  C12Q1/6858 ,  C12Q1/6869 ,  Y10S435/975

    摘要： This invention relates to an improvement of the procedure for amplifying a target nucleotide sequence by using an effective amount of a glycine-based osmolyte in the reaction mixture of an amplification procedure. It has been found that the use of a glycine-based osmolyte reduces the appearance of stutter bands in the amplification product allowing for easier detection of the target nucleotide sequence. For example, detection of the target trinucleotide repeat sequence, indicative of Huntington's Disease, is made clearer with the use of a glycine-based osmolyte.

    摘要翻译： 本发明涉及通过在扩增步骤的反应混合物中使用有效量的甘氨酸类渗透液来扩增靶核苷酸序列的方法的改进。 已经发现使用基于甘氨酸的渗透液减少了扩增产物中的口吃带的出现，从而更容易地检测到靶核苷酸序列。 例如，通过使用基于甘氨酸的渗透液，使得指示亨廷顿病的目标三核苷酸重复序列的检测变得更清楚。

    Live vaccine for coccidiosis utilizing coccidial sporozoites
    8.
    发明授权
    Live vaccine for coccidiosis utilizing coccidial sporozoites 失效
    使用球虫子孢子的球虫病活疫苗

    公开(公告)号：US5068104A

    公开(公告)日：1991-11-26

    申请号：US226894

    申请日：1988-08-01

    申请人： Balbir S. Bhogal ,  Michael G. Williams ,  Glenn A. Miller

    发明人： Balbir S. Bhogal ,  Michael G. Williams ,  Glenn A. Miller

    IPC分类号： A61K39/012

    CPC分类号： A61K39/012

    摘要： Methods and compositions are disclosed for vaccinating warm-blooded animals against coccidiosis utilizing suspensions of excysted coccidial sporozoites in physiologically balanced medium containing water-soluble polymeric stabilizers selected from gels, gelatins, polysaccharide gums, cellulose or cellulose derivatives which extend viability or storage, additional extension of viability in storage being attained when the suspensions are finely divided and the polymeric stabilizers are hardened to form microcapsules.Prior to administration, the microcapsule is treated with a chelating agent in order to provide greater efficiency and speed of sporozoite release from the microcapsule and thus improved innoculation against oocyst challenge when compared with microcapsules which have not been treated with a chelating agent.

    摘要翻译： 公开了用温血动物接种抗球虫病的方法和组合，所述悬浮液在生理平衡的培养基中含有可溶性聚合物稳定剂的悬浮液，所述水溶性聚合物稳定剂选自凝胶，明胶，多糖胶，纤维素或纤维素衍生物，其延伸活力或储存， 当悬浮液细分并且聚合物稳定剂硬化以形成微胶囊时，可以获得储存中的活力。 在给药前，用螯合剂处理微胶囊，以便提供从微胶囊释放子孢子的更大的效率和速度，并且因此与未用螯合剂处理的微胶囊相比，改善了针对卵囊攻击的接种。