公开(公告)号：US20090004101A1

公开(公告)日：2009-01-01

申请号：US11659877

申请日：2005-08-01

申请人： Glyn Taylor ,  Navdeep Thoofer ,  Richard Evans ,  Carole Evans ,  Benjamin Yerxa ,  Gregory Mossinghoff

发明人： Glyn Taylor ,  Navdeep Thoofer ,  Richard Evans ,  Carole Evans ,  Benjamin Yerxa ,  Gregory Mossinghoff

IPC分类号： A61K51/00 ,  A61K31/7068 ,  A61K31/708 ,  A61K38/16 ,  A61K31/7052 ,  A61K35/76 ,  A61K38/28 ,  C07H19/10 ,  C07H19/20 ,  A61K38/21 ,  A61K38/43 ,  A61K38/14 ,  A61K38/20 ,  A61K49/00

CPC分类号： A61K31/7076 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7115 ,  A61K31/7125 ,  A61K2300/00

摘要： The present invention provides a method of enhancing the absorption of molecules across the airway epithelium, thereby enhancing the delivery of desired therapeutic or diagnostic agents across the airway epithelium via the systemic circulation to the target site of action. The method comprises administration of a formulation comprising a pharmaceutical composition comprising a synthetic or natural nucleoside diphosphate, nucleoside triphosphate, or dinucleoside polyphosphate, together with a pharmaceutically acceptable carrier. Preferably the nucleotide is a P2Y receptor agonist which is administered at any time during treatment with a therapeutic or diagnostic agent. A preferred embodiment is a method of administering a pharmaceutical composition comprising a P2Y receptor agonist with enhanced resistance to extracellular hydrolysis, such as dinucleoside polyphosphate compounds.

摘要翻译： 本发明提供了增强分子穿过呼吸道上皮的吸收的方法，从而增强了所需治疗剂或诊断剂通过气道上皮通过全身循环递送至目标作用部位。 该方法包括给药包含合成或天然核苷二磷酸，核苷三磷酸或二核苷多磷酸盐的药物组合物以及药学上可接受的载体。 优选地，核苷酸是在用治疗剂或诊断剂治疗期间的任何时间施用的P2Y受体激动剂。 优选的实施方案是给予包含具有增强的细胞外水解抗性的P2Y受体激动剂的药物组合物的方法，例如二核苷多磷酸盐化合物。