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1.
公开(公告)号:US20110224410A1
公开(公告)日:2011-09-15
申请号:US12884414
申请日:2010-09-17
申请人: David HILE , Gregg STROHMEIER
发明人: David HILE , Gregg STROHMEIER
IPC分类号: C07K14/52
CPC分类号: A61K38/1875 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , C07K14/51
摘要: The present invention provides formulations of cysteine knot proteins, including TGF-β superfamily proteins and bone morphogenic proteins that are pH stabilized. In particular, the present invention relates to the observation that certain buffers enhance the stability of cysteine knot proteins, including TGF-β superfamily proteins and bone morphogenic proteins. In particular, disclosed herein are liquid and lyophilized formulations prepared with a glycylglycine and tartaric acid buffers to stabilize the pH of the formulation.
摘要翻译: 本发明提供了半胱氨酸结蛋白质的制剂,包括TGF- 超家族蛋白质和pH稳定的骨形态发生蛋白质。 特别地,本发明涉及某些缓冲液增强半胱氨酸结蛋白质的稳定性的观察,包括TGF- 超家族蛋白质和骨形态发生蛋白。 特别地,本文公开的是用甘氨酰甘氨酸和酒石酸缓冲液制备的液体和冻干制剂,以稳定制剂的pH。
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公开(公告)号:US20080095710A1
公开(公告)日:2008-04-24
申请号:US11775824
申请日:2007-07-10
申请人: Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail Pyle , Gary Gray , Indu Isaacs , Gregg Strohmeier
发明人: Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail Pyle , Gary Gray , Indu Isaacs , Gregg Strohmeier
CPC分类号: A61K38/4813 , A61K38/482
摘要: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
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公开(公告)号:US20050249719A1
公开(公告)日:2005-11-10
申请号:US10969314
申请日:2004-10-19
申请人: Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail Pyle , Gary Gray , Indu Isaacs , Gregg Strohmeier
发明人: Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail Pyle , Gary Gray , Indu Isaacs , Gregg Strohmeier
CPC分类号: A61K38/4813 , A23L29/06 , A61K38/482
摘要: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
摘要翻译: 将有效剂量的谷蛋白酶施用于腹腔炎或疱疹样皮炎患者可降低毒性麸质寡肽的含量,从而减弱或消除麸质的破坏作用。
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公开(公告)号:US20120156253A1
公开(公告)日:2012-06-21
申请号:US13289924
申请日:2011-11-04
申请人: Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail G. Pyle , Gary M. Gray , Indu Isaacs , Gregg Strohmeier
发明人: Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail G. Pyle , Gary M. Gray , Indu Isaacs , Gregg Strohmeier
CPC分类号: A61K38/48
摘要: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
摘要翻译: 将有效剂量的谷蛋白酶施用于腹腔炎或疱疹样皮炎患者可降低毒性麸质寡肽的含量,从而减弱或消除麸质的破坏作用。
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5.
公开(公告)号:US20140336114A1
公开(公告)日:2014-11-13
申请号:US14088623
申请日:2013-11-25
申请人: David D. Hile , Gregg Strohmeier
发明人: David D. Hile , Gregg Strohmeier
CPC分类号: A61K38/1875 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , C07K14/51
摘要: The present invention provides formulations of cysteine knot proteins, including TGF-β superfamily proteins and bone morphogenic proteins that are pH stabilized. In particular, the present invention relates to the observation that certain buffers enhance the stability of cysteine knot proteins, including TGF-β superfamily proteins and bone morphogenic proteins. In particular, disclosed herein are liquid and lyophilized formulations prepared with a glycylglycine and tartaric acid buffers to stabilize the pH of the formulation.
摘要翻译: 本发明提供了半胱氨酸结蛋白质的制剂,包括TGF- 超家族蛋白质和pH稳定的骨形态发生蛋白质。 特别地,本发明涉及某些缓冲液增强半胱氨酸结蛋白质的稳定性的观察,包括TGF- 超家族蛋白质和骨形态发生蛋白。 特别地,本文公开的是用甘氨酰甘氨酸和酒石酸缓冲液制备的液体和冻干制剂,以稳定制剂的pH。
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公开(公告)号:US08796201B2
公开(公告)日:2014-08-05
申请号:US13289924
申请日:2011-11-04
申请人: Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail G. Pyle , Gary M. Gray , Indu Isaacs , Gregg Strohmeier
发明人: Lu Shan , Michael Bethune , Chaitan Khosla , Jonathan Gass , Gail G. Pyle , Gary M. Gray , Indu Isaacs , Gregg Strohmeier
CPC分类号: A61K38/48
摘要: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
摘要翻译: 将有效剂量的谷蛋白酶施用于腹腔炎或疱疹样皮炎患者可降低毒性麸质寡肽的含量,从而减弱或消除麸质的破坏作用。
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7.
公开(公告)号:US20130172254A1
公开(公告)日:2013-07-04
申请号:US13615829
申请日:2012-09-14
申请人: David Hile , Gregg Strohmeier
发明人: David Hile , Gregg Strohmeier
IPC分类号: C07K14/51
CPC分类号: A61K38/1875 , A61K9/19 , A61K47/12 , A61K47/183 , A61K47/26 , C07K14/51
摘要: The present invention provides formulations of cysteine knot proteins, including TGF-β superfamily proteins and bone morphogenic proteins that are pH stabilized. In particular, the present invention relates to the observation that certain buffers enhance the stability of cysteine knot proteins, including TGF-β superfamily proteins and bone morphogenic proteins. In particular, disclosed herein are liquid and lyophilized formulations prepared with a glycylglycine and tartaric acid buffers to stabilize the pH of the formulation.
摘要翻译: 本发明提供半胱氨酸结蛋白质的制剂,包括pH稳定的TGF-β超家族蛋白质和骨形态发生蛋白质。 特别地,本发明涉及某些缓冲液增强半胱氨酸结蛋白(包括TGF-β超家族蛋白和骨形态发生蛋白)的稳定性的观察。 特别地,本文公开的是用甘氨酰甘氨酸和酒石酸缓冲液制备的液体和冻干制剂,以稳定制剂的pH。
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