公开(公告)号：US20060084169A1

公开(公告)日：2006-04-20

申请号：US11244890

申请日：2005-10-06

申请人： Gregor Boese ,  Wolfgang Albrecht ,  Guenther Malsch ,  Thomas Groth ,  Andreas Lendlein ,  Hans-Jurgen Stark ,  Norbert Fusenig

发明人： Gregor Boese ,  Wolfgang Albrecht ,  Guenther Malsch ,  Thomas Groth ,  Andreas Lendlein ,  Hans-Jurgen Stark ,  Norbert Fusenig

IPC分类号： C12N5/08

CPC分类号： B01D71/64 ,  B01D71/42 ,  C12N5/0068 ,  C12N2533/30

摘要： The invention relates to a polymer substrate for cultivating tissue cells. The substrate is provided in form of an oxygen-permeable flat membrane, preferably with ultra-filtration properties, and has an optimized amine content of at least 10 nmole amine function per cm2 membrane. The substrate can be used to treat burns and other tissue defects. The substrate can be rapidly populated with cells, in particular with keratinozytes, and supports reorientation of the cells after the populated membrane is transferred to a wound or a dermis equivalent. The substrate can also be later easily detached from the newly formed tissue structure.

摘要翻译： 本发明涉及一种培养组织细胞的聚合物底物。 基底以透氧的平膜的形式提供，优选具有超滤性质，并且具有每厘米膜至少10nmole胺功能的优化的胺含量。 该基质可用于治疗烧伤和其他组织缺陷。 底物可以用细胞，特别是用角蛋白酶快速填充，并且在将填充的膜转移到伤口或真皮等价物之后支持细胞的重新定向。 基底也可以随后从新形成的组织结构中容易地分离。